Aminopeptidase and the genes thereof
    2.
    发明授权
    Aminopeptidase and the genes thereof 失效
    氨基肽酶及其基因

    公开(公告)号:US07087422B2

    公开(公告)日:2006-08-08

    申请号:US10664958

    申请日:2003-09-22

    CPC分类号: C12N9/62

    摘要: The object of the present invention is to provide Koji mold aminopeptidases capable of efficiently hydrolyzing persistent peptides and also genes encoding the aminopeptidases. The present invention provides Aspergillus nidulans aminopeptidase and nucleic acid molecules encoding it. In particular, the present invention provides a protein having an amino acid sequence represented by amino acid Nos. 1 to 519 in SEQ ID NO: 2, or a protein containing the substitution, deletion, insertion, addition or inversion of one or more amino acids in said sequence, and which protein has an activity of catalyzing the reaction for releasing an amino acid at an N-terminal of a peptide, and nucleic acid molecules encoding them.

    摘要翻译: 本发明的目的是提供能够有效水解持久性肽的Koji模具氨基肽酶以及编码氨基肽酶的基因。 本发明提供构巢曲霉氨基肽酶和编码它的核酸分子。 特别地,本发明提供了具有SEQ ID NO:2中的氨基酸编号1〜519所示的氨基酸序列的蛋白质,或含有一个或多个氨基酸的取代,缺失,插入,添加或倒置的蛋白质 并且哪个蛋白质具有催化用于释放肽的N末端的氨基酸的反应的活性和编码它们的核酸分子的活性。