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    Process for the preparation of gelatin
    4.
    发明授权
    Process for the preparation of gelatin 有权
    制备明胶的方法

    公开(公告)号：US09593158B2

    公开(公告)日：2017-03-14

    申请号：US14427659

    申请日：2013-09-16

    申请人： DSM IP ASSETS B.V.

    发明人： Zhong-Hua Quan ,  Monica Diana Vlasie

    IPC分类号： C07K14/78 ,  C12P21/06 ,  C12N9/62

    CPC分类号： C07K14/78 ,  C12N9/62 ,  C12P21/06 ,  Y02P20/52

    摘要： The present invention relates to a process for preparing gelatin comprising a step of incubating a material comprising collagen with an enzyme composition comprising an acid protease which has at least 70% identity to the amino acid sequence of SEQ ID NO:1, and preparing the gelatin. The invention also relates to gelatin obtained by a process as disclosed herein.

    摘要翻译： 本发明涉及一种制备明胶的方法，其包括将包含胶原的材料与包含与SEQ ID NO：1的氨基酸序列具有至少70％同一性的酸性蛋白酶的酶组合物孵育的步骤，以及制备明胶 。 本发明还涉及通过本文公开的方法获得的明胶。

    MEDICAMENT AND METHOD FOR TREATING INNATE IMMUNE RESPONSE DISEASES
    5.
    发明申请
    MEDICAMENT AND METHOD FOR TREATING INNATE IMMUNE RESPONSE DISEASES 审中-公开
    治疗免疫应答疾病的药物和方法

    公开(公告)号：US20160346364A1

    公开(公告)日：2016-12-01

    申请号：US15101630

    申请日：2014-12-11

    申请人： DSM IP ASSETS B.V.

    发明人： Maaike Johanna BRUINS ,  Luppo EDENS ,  Lenneke NAN

    IPC分类号： A61K38/48 ,  A23L5/20 ,  A23L29/00 ,  A21D8/04 ,  A61K9/00 ,  C12N9/62

    CPC分类号： A61K38/488 ,  A21D8/042 ,  A23L5/25 ,  A23L29/06 ,  A23V2002/00 ,  A61K9/0053 ,  A61K38/482 ,  C12C5/004 ,  C12N9/62 ,  C12Y304/21026 ,  C12Y304/23018 ,  C12Y304/23019 ,  A61K2300/00

    摘要： This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.

    摘要翻译： 本发明涉及一种药物或膳食补充剂，其包含能够水解植物食物过敏原的黑曲霉曲霉菌肽酶，更具体地，涉及α-淀粉酶/胰蛋白酶抑制剂，从而治疗由于人的先天免疫应答引起的疾病，和/ 或允许延迟所述疾病的发作。 本发明涉及黑曲霉曲霉菌肽酶能够水解存在于小麦和相关谷物中的α-淀粉酶/胰蛋白酶抑制剂的发现，所述抑制剂是先天免疫应答的强诱导剂。 此外，本发明涉及水解α-淀粉酶/胰蛋白酶抑制剂的方法，包括将包含α-淀粉酶/胰蛋白酶抑制剂的食物组合物与黑曲霉曲霉菌肽酶一起孵育，其中所述抑制剂被水解。 它还涉及包含黑曲霉曲霉菌肽酶和另外的酶的酶组合物，以及包含黑曲霉曲霉菌肽酶的食品。

    IMMOBILIZED PROLINE-SPECIFIC ENDOPROTEASE
    7.
    发明申请
    IMMOBILIZED PROLINE-SPECIFIC ENDOPROTEASE 审中-公开
    固定化的特异性内切酶

    公开(公告)号：US20160102300A1

    公开(公告)日：2016-04-14

    申请号：US14893186

    申请日：2014-06-02

    申请人： DSM IP ASSETS B.V.

    发明人： Aida HISENI ,  Igor GALAEV ,  Luppo EDENS

    IPC分类号： C12N11/08 ,  C12C11/11 ,  C12C5/00 ,  C12N11/06 ,  C12N9/62

    CPC分类号： C12N11/08 ,  C12C5/004 ,  C12C11/11 ,  C12N9/62 ,  C12N11/06 ,  C12Y304/21026

    摘要： The present invention relates to immobilized proline-specific endoprotease, wherein the proline-specific endoprotease is immobilized on a carrier comprising methacrylate which has been functionalized with amino dimethylene, and wherein the carrier has a particle size range of 100 to 400 μm. The invention also relates to a process for producing beer comprising the steps of preparing a mash, fermenting the beer, and stabilizing the beer, wherein the beer is incubated with the immobilized proline-specific endoprotease.

    摘要翻译： 本发明涉及固定化的脯氨酸特异性内切蛋白酶，其中脯氨酸特异性内切蛋白酶固定在已经用氨基二亚甲基官能化的甲基丙烯酸酯的载体上，其中载体的粒度范围为100-400μm。 本发明还涉及一种生产啤酒的方法，包括制备糊状物，发酵啤酒和稳定啤酒的步骤，其中啤酒与固定化的脯氨酸特异性内切蛋白酶一起温育。

    Novel Fungal Protease and Use Thereof
    8.
    发明申请
    Novel Fungal Protease and Use Thereof 有权
    新型真菌蛋白酶及其用途

    公开(公告)号：US20130065810A2

    公开(公告)日：2013-03-14

    申请号：US12799639

    申请日：2010-04-28

    申请人： Kari Juntunen ,  Leena Valtakari ,  Susanna Makinen ,  Jarno Kallio ,  Jari Vehmaanpera ,  Pentti Ojapalo ,  Marja Paloheimo

    发明人： Kari Juntunen ,  Leena Valtakari ,  Susanna Makinen ,  Jarno Kallio ,  Jari Vehmaanpera ,  Pentti Ojapalo ,  Marja Paloheimo

    IPC分类号： C11D7/42 ,  C12N9/62 ,  A61K36/06 ,  C12N15/57 ,  C12P21/02 ,  C12N9/58 ,  C07H21/00

    CPC分类号： C12N9/58 ,  C11D3/386 ,  C11D3/38681

    摘要： The present invention is related to a fungal serine protease enzyme, which comprises an amino acid sequence of the mature Fe_RF6318 enzyme having an amino acid sequence of SEQ ID NO: 15. The serine protease is obtainable from Fusarium equiseti, more preferably from the deposited strain CBS 119568. Also disclosed are nucleic acid sequences encoding said protease, such as plasmid pALK2521 comprising the nucleotide sequence SEQ ID NO:9 deposited in E. coli RF7664 under accession number DSM 22171 and plasmid pALK2529 comprising the full-length gene SEQ ID NO: 10 deposited in E. coli RF7800 under accession number DSM 22172. Said protease is useful as an enzyme preparation applicable in detergent compositions and for treating fibers, for treating wool, for treating hair, for treating leather, for treating food or feed, or for any applications involving modification, degradation or removal of proteinaceous material.

    摘要翻译： 本发明涉及真菌丝氨酸蛋白酶，其包含具有SEQ ID NO：15的氨基酸序列的成熟Fe_RF6318酶的氨基酸序列。丝氨酸蛋白酶可从镰刀菌（Fusarium equiseti）获得，更优选来自沉积菌株 CBS 119568。还公开了编码所述蛋白酶的核酸序列，例如质粒pALK2521，其包含以保藏号DSM 22171保藏在大肠杆菌RF7664中的核苷酸序列SEQ ID NO：9和质粒pALK2529，质粒pALK2529包含全长基因SEQ ID NO： 10，以保藏号DSM 22172保藏在大肠杆菌RF7800中。所述蛋白酶可用作适用于洗涤剂组合物中的酶制剂，并用于处理纤维，用于处理羊毛，用于处理毛发，用于处理皮革，用于处理食品或饲料，或用于 任何涉及蛋白质物质修饰，降解或去除的应用。