公开(公告)号：US20060019974A1

公开(公告)日：2006-01-26

申请号：US10380908

申请日：2001-09-17

Applicant: Werner Mederski ,  Ralf Devant ,  Maria Devant ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  James Vickers ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark Player ,  Edward Jaeger ,  Richard Soll

Inventor： Werner Mederski ,  Ralf Devant ,  Maria Devant ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  James Vickers ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark Player ,  Edward Jaeger ,  Richard Soll

IPC: A61K31/517 ,  C07D403/02 ,  C07D239/94

CPC classification number: C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14

Abstract: Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

Abstract translation: 式（I）的喹唑啉其中R 1，R 2，R 2，R 3，R 4， 并且Y具有专利权利要求1中所示的含义，并且其盐或溶剂合物作为糖蛋白IbIX拮抗剂。

公开(公告)号：US07618988B2

公开(公告)日：2009-11-17

申请号：US10489960

申请日：2002-08-12

Applicant: Henning Böttcher ,  Ralf Devant ,  Maria Devant, legal representative ,  Gerd Bartoszyk ,  Hermann Russ ,  Frank Weber ,  Christoph Seyfried

Inventor： Henning Böttcher ,  Ralf Devant ,  Gerd Bartoszyk ,  Hermann Russ ,  Frank Weber ,  Christoph Seyfried

IPC: A61K31/135 ,  A61K31/33 ,  A61K31/395 ,  A61K31/535 ,  A61K31/54 ,  A61K31/58

CPC classification number: C07D405/12

Abstract: Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.

Abstract translation: 其中R具有权利要求1所述含义的式I化合物或其用于治疗锥体束外运动障碍和/或锥体外系运动障碍和/或治疗中的副作用的其旋光异构体或药学上可接受的盐之一 的精神分裂症引起的锥体外系症状（EPS）。

公开(公告)号：US20060229339A1

公开(公告)日：2006-10-12

申请号：US10489960

申请日：2002-08-12

Applicant: Henning Böttcher ,  Ralf Devant ,  Maria Devant ,  Gerd Bartoszyk ,  Hermann Russ ,  Frank Weber ,  Christoph Seyfried

Inventor： Henning Böttcher ,  Ralf Devant ,  Maria Devant ,  Gerd Bartoszyk ,  Hermann Russ ,  Frank Weber ,  Christoph Seyfried

IPC: A61K31/4433

CPC classification number: C07D405/12

Abstract: Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.

Abstract translation: 其中R具有权利要求1所述含义的式I化合物或其用于治疗锥体束外运动障碍和/或锥体外系运动障碍和/或治疗中的副作用的其旋光异构体或药学上可接受的盐之一 的精神分裂症引起的锥体外系症状（EPS）。

公开(公告)号：US06890930B1

公开(公告)日：2005-05-10

申请号：US10089166

申请日：2000-09-13

Applicant: Werner Mederski ,  Maria Devant ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  Guido Melzer ,  Bertram Cezane ,  Dalijit Dhanoa ,  Bao-Ping Zhoa ,  James Rinker ,  Mark Player ,  Richard Soll

Inventor： Ralf Devant

IPC: A61K31/505 ,  A61K31/517 ,  C07D239/72 ,  C07D239/74 ,  C07D239/91 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04

CPC classification number: C07D405/06 ,  C07D239/91 ,  C07D405/04 ,  C07D409/04

Abstract: Quinazolinones of formula (I) in which R, R1, R2, R3, R4, Y, Z, and m have the meaning indicated in patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

Abstract translation: 式（I）的喹唑啉酮，其中R 1，R 2，R 2，R 3，R 4， Y，Z和m具有专利权利要求1中所示的含义，其盐或溶剂合物作为糖蛋白IbIX拮抗剂。

公开(公告)号：US07547702B2

公开(公告)日：2009-06-16

申请号：US10380908

申请日：2001-09-17

Applicant: Werner Mederski ,  Maria Devant, legal representative ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  James Vickers ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark R. Player ,  Edward Jaegar ,  Richard Soll

Inventor： Ralf Devant

IPC: A61K31/517 ,  A61K31/535 ,  C07D239/72 ,  C07D413/12

CPC classification number: C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14

Abstract: Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein 1bIX antagonists.

Abstract translation: 其中R，R 1，R 2，R 3，R 4和Y具有专利权利要求1中所示含义的式（I）的喹唑啉及其作为糖蛋白1bIX拮抗剂的盐或溶剂合物。