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    Oral Pharmaceutical Composition of Anilinopyrimidine, Preparation and Use Thereof
    1.
    发明申请
    Oral Pharmaceutical Composition of Anilinopyrimidine, Preparation and Use Thereof 失效
    苯胺嘧啶的口服药物组合物，其制备和用途

    公开(公告)号：US20090324711A1

    公开(公告)日：2009-12-31

    申请号：US12307605

    申请日：2007-07-05

    申请人： Santa Fabiano ,  Mario Maio

    发明人： Santa Fabiano ,  Mario Maio

    IPC分类号： A61K9/66 ,  A61K31/497 ,  A61P35/04

    CPC分类号： A61K9/4858 ,  A61K9/14 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/506 ,  A61K47/6951 ,  B82Y5/00

    摘要： An oral pharmaceutical composition comprising a capsule dosage form containing a liquid fill composition including an anilinopyrimidine derivative of Formula (I) and a pharmaceutically acceptable excipient selected from the group consisting of polyethylene glycol, a glyceryl ester of capric acid or a mixture thereof. The liquid fill composition is formulated in a hard gelatin capsules and can be used for the preparation of a medicament for the treatment of cancer in particular AML.

    摘要翻译： 一种口服药物组合物，其包含含有液体填充组合物的胶囊剂型，所述液体填充组合物包含式（I）的苯胺基嘧啶衍生物和选自聚乙二醇，癸酸的甘油酯或其混合物的药学上可接受的赋形剂。 液体填充组合物配制成硬明胶胶囊，可用于制备用于治疗特别是AML的癌症的药物。

    Oral pharmaceutical composition of anilinopyrimidine, preparation and use thereof
    4.
    发明授权
    Oral pharmaceutical composition of anilinopyrimidine, preparation and use thereof 失效
    苯胺嘧啶的口服药物组合物，其制备及用途

    公开(公告)号：US08277839B2

    公开(公告)日：2012-10-02

    申请号：US12307605

    申请日：2007-07-05

    申请人： Santa Fabiano ,  Mario Maio

    发明人： Santa Fabiano ,  Mario Maio

    IPC分类号： A61K9/66 ,  A61K31/497 ,  A61P35/04

    CPC分类号： A61K9/4858 ,  A61K9/14 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/506 ,  A61K47/6951 ,  B82Y5/00

    摘要： An oral pharmaceutical composition comprising a capsule dosage form containing a liquid fill composition including an anilinopyrimidine derivative of Formula (I) and a pharmaceutically acceptable excipient selected from the group consisting of polyethylene glycol, a glyceryl ester of capric acid or a mixture thereof. The liquid fill composition is formulated in a hard gelatin capsules and can be used for the preparation of a medicament for the treatment of cancer in particular AML.

    摘要翻译： 一种口服药物组合物，其包含含有液体填充组合物的胶囊剂型，所述液体填充组合物包含式（I）的苯胺基嘧啶衍生物和选自聚乙二醇，癸酸的甘油酯或其混合物的药学上可接受的赋形剂。 液体填充组合物配制成硬明胶胶囊，可用于制备用于治疗特别是AML的癌症的药物。

    Microspheres of pancreatic enzymes with high stability and production method thereof
    5.
    发明授权
    Microspheres of pancreatic enzymes with high stability and production method thereof 有权
    具有高稳定性的胰酶微球及其制备方法

    公开(公告)号：US09259393B2

    公开(公告)日：2016-02-16

    申请号：US10416702

    申请日：2001-11-13

    申请人： Mario Maio

    发明人： Mario Maio

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  C12N11/08

    CPC分类号： A61K9/50 ,  A61K9/1641 ,  A61K9/5047 ,  A61K38/54 ,  C12N11/08

    摘要： The present invention refers to new microspheres including pancreatic enzymes, pharmaceutical compositions containing them, and a process to obtain them. The process here described doesn't involve the use of solvents and proves to be remarkably shorter and efficient than the producing methods of the prior arts. The microspheres obtained, including one or more pancreatic enzymes, one or more hydrophilic low-melting polymers and eventual excipients, have an high enzymatic activity, bio-availability and stability.

    摘要翻译： 本发明涉及包含胰酶的新微球，含有它们的药物组合物，以及获得它们的方法。 这里描述的方法不涉及使用溶剂并且证明比现有技术的制备方法显着更短和有效。 获得的包含一种或多种胰酶，一种或多种亲水性低熔点聚合物和最终赋形剂的微球具有高酶活性，生物利用度和稳定性。

    Process and apparatus for cooling and atomizing liquid or pasty-like substances
    9.
    发明申请
    Process and apparatus for cooling and atomizing liquid or pasty-like substances 审中-公开
    用于冷却和雾化液体或糊状物质的方法和设备

    公开(公告)号：US20070079629A1

    公开(公告)日：2007-04-12

    申请号：US10577929

    申请日：2004-10-27

    申请人： Mario Maio ,  Daniela Chicco ,  Luca Donati ,  Pierandrea Esposito

    发明人： Mario Maio ,  Daniela Chicco ,  Luca Donati ,  Pierandrea Esposito

    IPC分类号： F25C1/00 ,  C02F1/22

    CPC分类号： B01J2/04 ,  F25C1/00 ,  F25D3/10

    摘要： A process and an apparatus for the rapid cooling and atomization of liquid or pasty substances, in particular even relatively small amounts of liquid or pasty substances being able to be cooled and atomized economically. Both process and apparatus are particularly useful in the pharmaceutical industry for preparing injectable microparticles of polymer or lipid matrices suitable for the incorporation of active ingredients.

    摘要翻译： 用于液体或糊状物质的快速冷却和雾化的方法和装置，特别是甚至能够经济地冷却和雾化的相对少量的液体或糊状物质。 方法和装置在医药工业中特别有用，用于制备适于掺入活性成分的聚合物或脂质基质的可注射微粒。