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    Process and apparatus for cooling and atomizing liquid or pasty-like substances
    3.
    发明申请
    Process and apparatus for cooling and atomizing liquid or pasty-like substances 审中-公开
    用于冷却和雾化液体或糊状物质的方法和设备

    公开(公告)号：US20070079629A1

    公开(公告)日：2007-04-12

    申请号：US10577929

    申请日：2004-10-27

    申请人： Mario Maio ,  Daniela Chicco ,  Luca Donati ,  Pierandrea Esposito

    发明人： Mario Maio ,  Daniela Chicco ,  Luca Donati ,  Pierandrea Esposito

    IPC分类号： F25C1/00 ,  C02F1/22

    CPC分类号： B01J2/04 ,  F25C1/00 ,  F25D3/10

    摘要： A process and an apparatus for the rapid cooling and atomization of liquid or pasty substances, in particular even relatively small amounts of liquid or pasty substances being able to be cooled and atomized economically. Both process and apparatus are particularly useful in the pharmaceutical industry for preparing injectable microparticles of polymer or lipid matrices suitable for the incorporation of active ingredients.

    摘要翻译： 用于液体或糊状物质的快速冷却和雾化的方法和装置，特别是甚至能够经济地冷却和雾化的相对少量的液体或糊状物质。 方法和装置在医药工业中特别有用，用于制备适于掺入活性成分的聚合物或脂质基质的可注射微粒。

    Biphasic multicomponent pharmaceutical dosage forms containing substances able to modify the partitioning of drugs
    9.
    发明授权
    Biphasic multicomponent pharmaceutical dosage forms containing substances able to modify the partitioning of drugs 失效
    含有能够改变药物分配的物质的双相多组分药物剂型

    公开(公告)号：US06495160B2

    公开(公告)日：2002-12-17

    申请号：US09214813

    申请日：1999-10-01

    申请人： Pierandrea Esposito ,  Nicoletta Coceani ,  Maria Dorly Del Curto ,  Fabio Carli

    发明人： Pierandrea Esposito ,  Nicoletta Coceani ,  Maria Dorly Del Curto ,  Fabio Carli

    IPC分类号： A61K970

    CPC分类号： A61K9/06 ,  A61K47/22

    摘要： The invention provides a biphasic multicomponent pharmaceutical composition consisting of an oil phase and a water phase, comprising one or more lipophilic or oil carrier, one or more hydrophilic or aqueous carrier, one or more ionic or nonionic type surfactant, one or more cosurfactant, one or more active principle for pharmaceutical use, and a compound able to modify the partition of the active principle between said phases selected from the group consisting of N- methyl pyrrolidone (NMP), isopropyl alcohol, propylene glycol, ethoxy-di-glycol, &bgr;-cyclodextrin, hydroxypropyl &bgr;-cyclodextrin and dimethyl &bgr;-cyclodextrin. The invention also provides a method for making the composition.

    摘要翻译： 本发明提供由油相和水相组成的双相多组分药物组合物，其包含一种或多种亲脂性或油载体，一种或多种亲水或水性载体，一种或多种离子型或非离子型表面活性剂，一种或多种辅助表面活性剂，一种 或更有效的药物用途原理，以及能够改变选自N-甲基吡咯烷酮（NMP），异丙醇，丙二醇，乙氧基 - 二醇，β的所述相之间活性成分分配的化合物 环糊精，羟丙基β-环糊精和二甲基β-环糊精。 本发明还提供了制备组合物的方法。