利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.016 秒)

    Humanized anti-CD3 antibodies
    1.
    发明授权
    Humanized anti-CD3 antibodies 有权
    人源化抗CD3抗体

    公开(公告)号：US07994289B2

    公开(公告)日：2011-08-09

    申请号：US10463442

    申请日：2003-06-18

    申请人： Herman Waldmann ,  Mark Frewin

    发明人： Herman Waldmann ,  Mark Frewin

    IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  C12P21/04

    CPC分类号： C07K16/2809 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2319/00

    摘要： An IgG antibody is provided having a binding affinity for the CD3 antigen complex in which in the heavy chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 2, 4 and 6 and respective conservatively modified variants thereof and the light chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 8, 10 and 12 and respective conservatively modified variants thereof characterised in that the heavy chain variable region framework corresponds in sequence to the human type sequence and the light chain variable region framework includes one or more of the specific amino acids characteristic of the rodent type sequence. The novel antibody is capable of being expressed by mammalian cell expression systems at enhanced yields.

    摘要翻译： 提供具有对CD3抗原复合物的结合亲和力的IgG抗体，其中在重链中具有可选区域框架以及选自SEQ ID No 2,4和6的氨基酸序列的至少一个CDR，并且各自保守修饰 其轻链具有可变区框架以及选自SEQ ID No 8,10和12的氨基酸序列的至少一个CDR及其各自的保守修饰变体，其特征在于重链可变区框架依次对应 涉及人类序列，轻链可变区框架包括啮齿动物型序列特征的一种或多种特定氨基酸。 新型抗体能够以增强的产量被哺乳动物细胞表达系统表达。

    Antibody preparation
    3.
    发明申请
    Antibody preparation 有权
    抗体制备

    公开(公告)号：US20070092516A1

    公开(公告)日：2007-04-26

    申请号：US11581008

    申请日：2006-10-16

    申请人： Herman Waldmann ,  Mark Frewin

    发明人： Herman Waldmann ,  Mark Frewin

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/30

    CPC分类号： C07K16/2809 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2319/00

    摘要： An IgG antibody is provided having a binding affinity for the CD3 antigen complex in which in the heavy chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 2, 4 and 6 and respective conservatively modified variants thereof and the light chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 8, 10 and 12 and respective conservatively modified variants thereof characterised in that the heavy chain variable region framework corresponds in sequence to the human type sequence and the light chain variable region framework includes one or more of the specific amino acids characteristic of the rodent type sequence. The novel antibody is capable of being expressed by mammalian cell expression systems at enhanced yields.

    摘要翻译： 提供具有对CD3抗原复合物的结合亲和力的IgG抗体，其中在重链中具有可选区域框架以及选自SEQ ID No 2,4和6的氨基酸序列的至少一个CDR，并且各自保守修饰 其轻链具有可变区框架以及选自SEQ ID No 8,10和12的氨基酸序列的至少一个CDR及其各自的保守修饰变体，其特征在于重链可变区框架依次对应 涉及人类序列，轻链可变区框架包括啮齿动物型序列特征的一种或多种特定氨基酸。 新型抗体能够以增强的产量被哺乳动物细胞表达系统表达。

    ANTIBODY PREPARATION
    5.
    发明申请
    ANTIBODY PREPARATION 审中-公开
    抗体制剂

    公开(公告)号：US20110282037A1

    公开(公告)日：2011-11-17

    申请号：US13162755

    申请日：2011-06-17

    申请人： Herman WALDMANN ,  Mark Frewin

    发明人： Herman WALDMANN ,  Mark Frewin

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2809 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2319/00

    摘要： An IgG antibody is provided having a binding affinity for the CD3 antigen complex in which in the heavy chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 2, 4 and 6 and respective conservatively modified variants thereof and the light chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 8, 10 and 12 and respective conservatively modified variants thereof characterised in that the heavy chain variable region framework corresponds in sequence to the human type sequence and the light chain variable region framework includes one or more of the specific amino acids characteristic of the rodent type sequence. The novel antibody is capable of being expressed by mammalian cell expression systems at enhanced yields.

    摘要翻译： 提供具有对CD3抗原复合物的结合亲和力的IgG抗体，其中在重链中具有可选区域框架以及选自SEQ ID No 2,4和6的氨基酸序列的至少一个CDR，并且各自保守修饰 其轻链具有可变区框架以及选自SEQ ID No 8,10和12的氨基酸序列的至少一个CDR及其各自的保守修饰变体，其特征在于重链可变区框架依次对应 涉及人类序列，轻链可变区框架包括啮齿动物型序列特征的一种或多种特定氨基酸。 新型抗体能够以增强的产量被哺乳动物细胞表达系统表达。

    Methods of treatment using anti-CD3 antibodies
    6.
    发明授权
    Methods of treatment using anti-CD3 antibodies 有权
    使用抗CD3抗体的治疗方法

    公开(公告)号：US07993641B2

    公开(公告)日：2011-08-09

    申请号：US11581008

    申请日：2006-10-16

    申请人： Herman Waldmann ,  Mark Frewin

    发明人： Herman Waldmann ,  Mark Frewin

    IPC分类号： A61K39/395 ,  C12P21/04 ,  C12P21/08 ,  C07K16/00

    CPC分类号： C07K16/2809 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2319/00

    摘要： An IgG antibody is provided having a binding affinity for the CD3 antigen complex in which in the heavy chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 2, 4 and 6 and respective conservatively modified variants thereof and the light chain has a variable region framework together with at least one CDR selected from the amino acid sequences of SEQ ID No 8, 10 and 12 and respective conservatively modified variants thereof characterised in that the heavy chain variable region framework corresponds in sequence to the human type sequence and the light chain variable region framework includes one or more of the specific amino acids characteristic of the rodent type sequence. The novel antibody is capable of being expressed by mammalian cell expression systems at enhanced yields.

    摘要翻译： 提供具有对CD3抗原复合物的结合亲和力的IgG抗体，其中在重链中具有可选区域框架以及选自SEQ ID No 2,4和6的氨基酸序列的至少一个CDR，并且各自保守修饰 其轻链具有可变区框架以及选自SEQ ID No 8,10和12的氨基酸序列的至少一个CDR及其各自的保守修饰变体，其特征在于重链可变区框架依次对应 涉及人类序列，轻链可变区框架包括啮齿动物型序列特征的一种或多种特定氨基酸。 新型抗体能够以增强的产量被哺乳动物细胞表达系统表达。