公开(公告)号：US07643870B2

公开(公告)日：2010-01-05

申请号：US11619056

申请日：2007-01-02

申请人： Mark Kohls

发明人： Mark Kohls

IPC分类号： A61B5/0402

CPC分类号： A61B5/411 ,  A61B5/0452 ,  G06F19/00 ,  G16H10/20

摘要： The present disclosure includes a method and system for managing ECGs in a clinical trial including a processor, storage media, ECG acquisition system, user interface device, and the appropriate databases configured to collect and store a set of trial specific drug ECG recordings. The system and method allows a trial administrator to select a set of placebo ECG recordings and a set of known QT prolonged ECG recordings from databases and adjust these sets according to the parameters of the study. Interpretations are made on this superset of ECG recordings and the interpretation is outputted to a user.

摘要翻译： 本公开包括用于在临床试验中管理ECG的方法和系统，包括处理器，存储介质，ECG采集系统，用户界面设备以及被配置为收集和存储一组试用特异性药物ECG记录的适当数据库。 系统和方法允许试验管理员从数据库中选择一组安慰剂心电图记录和一组已知的QT延长的ECG记录，并根据研究的参数调整这些组。 对这种ECG记录超集进行了解释，并将解释输出给用户。

公开(公告)号：US20080161704A1

公开(公告)日：2008-07-03

申请号：US11619056

申请日：2007-01-02

申请人： Mark Kohls

发明人： Mark Kohls

IPC分类号： A61B5/0402

CPC分类号： A61B5/411 ,  A61B5/0452 ,  G06F19/00 ,  G16H10/20

摘要： The present disclosure includes a method and system for managing ECGs in a clinical trial including a processor, storage media, ECG acquisition system, user interface device, and the appropriate databases configured to collect and store a set of trial specific drug ECG recordings. The system and method allows a trial administrator to select a set of placebo ECG recordings and a set of known QT prolonged ECG recordings from databases and adjust these sets according to the parameters of the study. Interpretations are made on this superset of ECG recordings and the interpretation is outputted to a user.

摘要翻译： 本公开包括用于在临床试验中管理ECG的方法和系统，包括处理器，存储介质，ECG采集系统，用户界面设备以及被配置为收集和存储一组试用特异性药物ECG记录的适当数据库。 系统和方法允许试验管理员从数据库中选择一组安慰剂心电图记录和一组已知的QT延长的ECG记录，并根据研究的参数调整这些组。 对这种ECG记录超集进行了解释，并将解释输出给用户。

公开(公告)号：US20050107978A1

公开(公告)日：2005-05-19

申请号：US10716285

申请日：2003-11-18

申请人： Mark Kohls

发明人： Mark Kohls

IPC分类号： A61B5/0432 ,  G01D1/00

CPC分类号： A61B5/0432

摘要： A technique is provided for encoding physiological data, such as a digital ECG, as a set of high-resolution symbols. The set of high-resolution symbols may be printed on a printout of the physiological data or other suitable medium. The set of high-resolution symbols may scanned, or otherwise acquired, and decoded to reconstruct all or a portion of the original set of physiological data.

摘要翻译： 提供了用于将生理数据（例如数字ECG）编码为一组高分辨率符号的技术。 该组高分辨率符号可以打印在生理数据或其它合适介质的打印输出上。 可以扫描或以其他方式获取并解码该组高分辨率符号以重构原始生理数据集的全部或一部分。

公开(公告)号：US06763260B2

公开(公告)日：2004-07-13

申请号：US09682681

申请日：2001-10-05

申请人： Mark Kohls

发明人： Mark Kohls

IPC分类号： A61B600

CPC分类号： A61B6/481 ,  A61B6/504

摘要： A system for acquiring a plurality of internal images of a patient. The system includes a housing connectable to a medium movement sensor. The medium movement sensor generates a movement signal regarding a movement of the medium. The housing is also connectable to an imaging device. The imaging device acquires the internal images upon receiving a control signal having an acquire output. The system further includes a controller secured to the housing. The controller is operable to receive the movement signal, to generate a control signal having an acquire output based on the movement signal, and to provide the control signal having an acquire output to the imaging device.

摘要翻译： 一种用于获取患者的多个内部图像的系统。 该系统包括可连接到介质运动传感器的壳体。 介质运动传感器产生关于介质运动的运动信号。 外壳也可连接到成像装置。 成像装置在接收到具有获取输出的控制信号时获取内部图像。 该系统还包括固定到壳体的控制器。 控制器可操作以接收移动信号，以产生具有基于移动信号的获取输出的控制信号，并且向成像装置提供具有获取输出的控制信号。

公开(公告)号：US06748256B2

公开(公告)日：2004-06-08

申请号：US09683771

申请日：2002-02-12

申请人： Donald E. Brodnick ,  Mark Kohls ,  Carrie L. Kohls ,  April K. Kohls

发明人： Donald E. Brodnick ,  Mark Kohls ,  Carrie L. Kohls ,  April K. Kohls

IPC分类号： A61B50408

CPC分类号： A61B5/0408 ,  A61B5/0428 ,  A61B5/061 ,  A61B5/7207

摘要： A physiological-signal-analysis device including a lead set connected to a central unit. The lead set includes a plurality of electrodes connectable to a patient. Each electrode has a non-alphanumeric symbol that defines a placement of the electrode on the patient in relation to the other electrodes. The lead set further includes a plurality of lead wires. Each lead wire is connected to one of the electrodes, respectively, and has a symbol that defines the electrode connected to the lead wire. The electrodes may be provided to an attendant as an electrode pack.

摘要翻译： 一种生理信号分析装置，包括连接到中央单元的引线组。 引线组包括可连接到患者的多个电极。 每个电极具有非字母数字符号，其限定了相对于其它电极在患者身上放置电极。 引线组还包括多根引线。 每个引线分别连接到一个电极，并且具有限定连接到引线的电极的符号。 电极可以作为电极组提供给服务员。

公开(公告)号：US20080082015A1

公开(公告)日：2008-04-03

申请号：US11538343

申请日：2006-10-03

申请人： Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Q. Xue

发明人： Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Q. Xue

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B2560/0276

摘要： A pre-conditioned ECG system and method includes a patient signaling device configured to alert the patient to minimize the patient's activity so that an ECG measurement may be taken, and further alerts the patient when the measurement is completed. The pre-conditioned ECG system and method also includes a pre-set buffer configured to hold a preset length of ECG data, and further configured to hold pre-set ECG parameters such as mean R-R interval, standard deviation of R-R interval, or simple rhythm analysis. The system and method may analyze the current 10 seconds of ECG data when the preset parameters are met or when selected parameters are met.

摘要翻译： 预调节心电图系统和方法包括患者信号装置，其被配置为警告患者以最小化患者的活动，使得可以进行ECG测量，并且当测量完成时进一步警告患者。 所述预处理ECG系统和方法还包括预置缓冲器，其被配置为保持预设长度的ECG数据，并且还被配置为保持预设的ECG参数，例如平均RR间隔，RR间期的标准偏差或简单节奏 分析。 当满足预设参数或满足选择的参数时，系统和方法可以分析当前10秒的ECG数据。

公开(公告)号：US07593764B2

公开(公告)日：2009-09-22

申请号：US11538353

申请日：2006-10-03

申请人： Mark Kohls ,  Ian Rowlandson ,  Joel Xue

发明人： Mark Kohls ,  Ian Rowlandson ,  Joel Xue

IPC分类号： A61B5/0402

CPC分类号： A61B5/0452 ,  G06F19/00

摘要： The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

摘要翻译： 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

公开(公告)号：US20100004549A1

公开(公告)日：2010-01-07

申请号：US12563713

申请日：2009-09-21

申请人： Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Xue

发明人： Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Xue

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452

摘要： The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

摘要翻译： 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

公开(公告)号：US20080082016A1

公开(公告)日：2008-04-03

申请号：US11538353

申请日：2006-10-03

申请人： Mark Kohls ,  Gordon Ina Rowlandson ,  Joel Xue

发明人： Mark Kohls ,  Gordon Ina Rowlandson ,  Joel Xue

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  G06F19/00

摘要： The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

摘要翻译： 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

公开(公告)号：US20070168149A1

公开(公告)日：2007-07-19

申请号：US11611125

申请日：2006-12-14

申请人： Mark Kohls ,  Bonnie LeSourd

发明人： Mark Kohls ,  Bonnie LeSourd

IPC分类号： G01D1/00 ,  A61B5/04

CPC分类号： A61B5/0432 ,  G06F19/00

摘要： Various methods related to encoding and retrieving physiological data, such as digital ECG data, via a set of binary data are provided. In one embodiment, the set of binary data may be generated from the physiological data and printed on a printout of the physiological data or some other suitable medium. In another embodiment, the set of binary data may be scanned or otherwise acquired, and decoded to reconstruct all or a portion of the original set of physiological data. Additional methods and articles of manufacture are also provided.

摘要翻译： 提供了通过一组二进制数据编码和检索诸如数字ECG数据的生理数据的各种方法。 在一个实施例中，二进制数据集可以从生理数据生成并打印在生理数据或某些其他合适的介质的打印输出上。 在另一个实施例中，可以扫描或以其他方式获取二进制数据集，并对其进行解码以重建原始生理数据集的全部或一部分。 还提供了附加的方法和制品。