公开(公告)号：US09370310B2

公开(公告)日：2016-06-21

申请号：US11654922

申请日：2007-01-18

Applicant: Yao Chen ,  Kai Thomenius ,  Yongsheng Yang ,  Fei Teng ,  Yong Zhang ,  Jian Zhou ,  Joel Xue

Inventor： Yao Chen ,  Kai Thomenius ,  Yongsheng Yang ,  Fei Teng ,  Yong Zhang ,  Jian Zhou ,  Joel Xue

IPC: A61B5/0402 ,  A61B6/00 ,  A61B5/00 ,  A61B8/08

CPC classification number: A61B5/0402 ,  A61B5/04028 ,  A61B5/725 ,  A61B5/7278 ,  A61B5/742 ,  A61B6/503 ,  A61B8/0883

Abstract: A method is provided for determining cellular electrical potentials using a state estimator. The state estimator is generated using at least an electrical source model and an electrical conduction model. One or more parameters or states of the state estimator are adjusted based on a measured electrocardiographic and/or a measured body-surface-potential signal. The electrical potential of one or more cells is determined based on the one or more adjusted parameters or states. In one aspect of the present technique, one or more representations of an organ comprising the one or more cells is generated such that the electrical potential or its deriving characteristic of the one or more cells is visually indicated.

Abstract translation: 提供了一种使用状态估计器来确定细胞电位的方法。 状态估计器使用至少一个电源模型和电传导模型来产生。 基于测量的心电图和/或测量的体表电位信号来调整状态估计器的一个或多个参数或状态。 基于一个或多个调整的参数或状态来确定一个或多个单元的电位。 在本技术的一个方面，生成包含一个或多个细胞的器官的一个或多个表示，使得在视觉上指示一个或多个细胞的电位或其导出特征。

公开(公告)号：US20050234363A1

公开(公告)日：2005-10-20

申请号：US10825495

申请日：2004-04-15

Applicant: Joel Xue

Inventor： Joel Xue

IPC: A61B5/0402 ,  A61B5/0452

CPC classification number: A61B5/0452

Abstract: Method and apparatus for determining alternans data of an ECG signal. The method can include determining at least one value representing at least one morphology feature of each beat of the ECG signal and generating a set of data points based on a total quantity of values and a total quantity of beats. The data points can each include a first value determined using a first mathematical function and a second value determined using a second mathematical function. The method can also include several preprocessing algorithms to improve the signal to noise ratio. The method can also include separating the data points into a first group of points and a second group of points and generating a feature map by plotting the first group of points and the second group of points in order to assess an alternans pattern of variation. The feature map can be analyzed by statistical tests to determine the significance difference between groups and clusters.

Abstract translation: 用于确定ECG信号的交替数据的方法和装置。 该方法可以包括确定表示ECG信号的每个节拍的至少一个形态特征的至少一个值，并且基于总的总量和总搏动次数生成一组数据点。 数据点可以各自包括使用第一数学函数确定的第一值和使用第二数学函数确定的第二值。 该方法还可以包括几种预处理算法来提高信噪比。 该方法还可以包括将数据点分成第一组点和第二组点，并通过绘制第一组点和第二组点来生成特征图，以便评估交替变化模式。 可以通过统计检验来分析特征图，以确定组与群集之间的显着性差异。

公开(公告)号：US20050154282A1

公开(公告)日：2005-07-14

申请号：US10749646

申请日：2003-12-31

Applicant: Wenguang Li ,  Curtis Neason ,  Joel Xue

Inventor： Wenguang Li ,  Curtis Neason ,  Joel Xue

IPC: A61B5/042 ,  A61B5/044 ,  A61B6/00 ,  A61B5/05

CPC classification number: A61B8/5238 ,  A61B5/042 ,  A61B5/044 ,  A61B5/7289 ,  A61B6/00 ,  A61B6/5247 ,  A61B8/0883

Abstract: A system and method is provided for registering a representation of a probe with an image. One embodiment of a method comprises acquiring an image pertaining to an organ or structure inside a body and registering a representation of a probe which is inside the body with the image, the representation of the probe and the image being registered to substantially the same point in a bodily cycle.

Abstract translation: 提供了一种用于将具有图像的探针的表示注册的系统和方法。 一种方法的一个实施例包括获取与身体内的器官或结构有关的图像，并将身体内的探针的表示与图像，探针的表示和被注册到基本相同点的图像进行登记 身体循环。

公开(公告)号：US20100004549A1

公开(公告)日：2010-01-07

申请号：US12563713

申请日：2009-09-21

Applicant: Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Xue

Inventor： Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Xue

IPC: A61B5/0452

CPC classification number: A61B5/0452

Abstract: The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

Abstract translation: 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

公开(公告)号：US20080177192A1

公开(公告)日：2008-07-24

申请号：US11654922

申请日：2007-01-18

Applicant: Yao Chen ,  Kai Thomenius ,  Yongsheng Yang ,  Fei Teng ,  Yong Zhang ,  Jian Zhou ,  Joel Xue

Inventor： Yao Chen ,  Kai Thomenius ,  Yongsheng Yang ,  Fei Teng ,  Yong Zhang ,  Jian Zhou ,  Joel Xue

IPC: A61B5/04 ,  A61B5/0402

CPC classification number: A61B5/0402 ,  A61B5/04028 ,  A61B5/725 ,  A61B5/7278 ,  A61B5/742 ,  A61B6/503 ,  A61B8/0883

Abstract: A method is provided for determining cellular electrical potentials using a state estimator. The state estimator is generated using at least an electrical source model and an electrical conduction model. One or more parameters or states of the state estimator are adjusted based on a measured electrocardiographic and/or a measured body-surface-potential signal. The electrical potential of one or more cells is determined based on the one or more adjusted parameters or states. In one aspect of the present technique, one or more representations of an organ comprising the one or more cells is generated such that the electrical potential or its deriving characteristic of the one or more cells is visually indicated.

Abstract translation: 提供了一种使用状态估计器来确定细胞电位的方法。 状态估计器使用至少一个电源模型和电传导模型来产生。 基于测量的心电图和/或测量的体表电位信号来调整状态估计器的一个或多个参数或状态。 基于一个或多个调整的参数或状态来确定一个或多个单元的电位。 在本技术的一个方面，生成包含一个或多个细胞的器官的一个或多个表示，使得在视觉上指示一个或多个细胞的电位或其导出特征。

公开(公告)号：US20080082016A1

公开(公告)日：2008-04-03

申请号：US11538353

申请日：2006-10-03

Applicant: Mark Kohls ,  Gordon Ina Rowlandson ,  Joel Xue

Inventor： Mark Kohls ,  Gordon Ina Rowlandson ,  Joel Xue

IPC: A61B5/04

CPC classification number: A61B5/0452 ,  G06F19/00

Abstract: The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

Abstract translation: 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

公开(公告)号：US20070244405A1

公开(公告)日：2007-10-18

申请号：US11405151

申请日：2006-04-17

Applicant: Joel Xue ,  G. Rowlandson

Inventor： Joel Xue ,  G. Rowlandson

IPC: A61B5/04

CPC classification number: A61B5/0452 ,  A61B5/0006 ,  G06F19/00 ,  G16H10/20

Abstract: In a multi-tier patient monitoring data analysis system, an algorithm server is positioned as a middle tier between an acquisition device, such as a cardiograph or patient monitor that can be seen as a lower tier, and a storage device for a database, such as that of a central computer for a hospital or clinic that can be seen as an upper tier. The algorithm server gathers current data from the real time acquisition device and obtains previously stored ECG signal data from the database. The algorithm server contains ECG analysis algorithm(s) and runs one or more algorithms using the current and previously acquired ECG signal data. Analysis algorithms may also be run on the acquisition device. The system provides the rapid, extensive, and thorough ECG analysis that is critical to patient welfare.

Abstract translation: 在多级患者监测数据分析系统中，算法服务器被定位为可以被视为较低层的采集设备（例如心电图仪或患者监护仪）和数据库的存储设备之间的中间层，例如 像医院或诊所的中央计算机，可以看作是上层。 算法服务器从实时采集设备收集当前数据，并从数据库获取以前存储的ECG信号数据。 算法服务器包含ECG分析算法，并使用当前和之前获取的ECG信号数据运行一个或多个算法。 分析算法也可以在采集设备上运行。 该系统提供对患者福利至关重要的快速，广泛和彻底的心电图分析。

公开(公告)号：US20060173372A1

公开(公告)日：2006-08-03

申请号：US11393614

申请日：2006-03-30

Applicant: Joel Xue

Inventor： Joel Xue

IPC: A61B5/04

CPC classification number: A61B5/0452

Abstract: Method and apparatus for determining alternans data of an ECG signal. The method can include determining at least one value representing at least one morphology feature of each beat of the ECG signal and generating a set of data points based on a total quantity of values and a total quantity of beats. The data points can each include a first value determined using a first mathematical function and a second value determined using a second mathematical function. The method can also include several preprocessing algorithms to improve the signal to noise ratio. The method can also include separating the data points into a first group of points and a second group of points and generating a feature map by plotting the first group of points and the second group of points in order to assess an alternans pattern of variation. The feature map can be analyzed by statistical tests to determine the significance difference between groups and clusters.

公开(公告)号：US20060173371A1

公开(公告)日：2006-08-03

申请号：US11393575

申请日：2006-03-30

Applicant: Joel Xue

Inventor： Joel Xue

IPC: A61B5/04

CPC classification number: A61B5/0452

Abstract: Method and apparatus for determining alternans data of an ECG signal. The method can include determining at least one value representing at least one morphology feature of each beat of the ECG signal and generating a set of data points based on a total quantity of values and a total quantity of beats. The data points can each include a first value determined using a first mathematical function and a second value determined using a second mathematical function. The method can also include several preprocessing algorithms to improve the signal to noise ratio. The method can also include separating the data points into a first group of points and a second group of points and generating a feature map by plotting the first group of points and the second group of points in order to assess an alternans pattern of variation. The feature map can be analyzed by statistical tests to determine the significance difference between groups and clusters.

公开(公告)号：US20050038352A1

公开(公告)日：2005-02-17

申请号：US10912518

申请日：2004-08-05

Applicant: Joel Xue ,  Shankara Reddy

Inventor： Joel Xue ,  Shankara Reddy

IPC: A61B5/044

CPC classification number: A61B5/044 ,  A61B5/7264

Abstract: A method of displaying a representation of a physiological signal produced by a patient. The method includes the acts of obtaining a portion of at least one physiological signal acquired from the patient, determining an area to display, and constructing a virtual image representing at least a portion of the patient. The virtual image including (M) polygonal areas. The method further includes transforming the obtained signal to a plurality of values, assigning each value to one of the (M) polygonal areas, assigning a visual characteristic to each polygonal area based in part on the assigned values, and displaying at least a portion of the virtual image including the assigned visual characteristics. The invention further provides a method of optimal feature selection for the classification of the physiological signals produced by a patient.