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    SYSTEM AND METHOD OF SERIAL COMPARISON FOR DETECTION OF LONG QT SYNDROME (LQTS)
    1.
    发明申请
    SYSTEM AND METHOD OF SERIAL COMPARISON FOR DETECTION OF LONG QT SYNDROME (LQTS) 有权
    用于检测长QT综合征（LQTS）的串联比较系统和方法

    公开(公告)号：US20080082016A1

    公开(公告)日：2008-04-03

    申请号：US11538353

    申请日：2006-10-03

    申请人： Mark Kohls ,  Gordon Ina Rowlandson ,  Joel Xue

    发明人： Mark Kohls ,  Gordon Ina Rowlandson ,  Joel Xue

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0452 ,  G06F19/00

    摘要： The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

    摘要翻译： 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

    System and method of serial comparison for detection of long QT syndrome (LQTS)
    2.
    发明授权
    System and method of serial comparison for detection of long QT syndrome (LQTS) 有权
    用于检测长QT综合征（LQTS）的串联比较系统和方法

    公开(公告)号：US07593764B2

    公开(公告)日：2009-09-22

    申请号：US11538353

    申请日：2006-10-03

    申请人： Mark Kohls ,  Ian Rowlandson ,  Joel Xue

    发明人： Mark Kohls ,  Ian Rowlandson ,  Joel Xue

    IPC分类号： A61B5/0402

    CPC分类号： A61B5/0452 ,  G06F19/00

    摘要： The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

    摘要翻译： 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

    SYSTEM AND METHOD OF SERIAL COMPARISON FOR DETECTION OF LONG QT SYNDROME (LQTS)
    3.
    发明申请
    SYSTEM AND METHOD OF SERIAL COMPARISON FOR DETECTION OF LONG QT SYNDROME (LQTS) 审中-公开
    用于检测长QT综合征（LQTS）的串联比较系统和方法

    公开(公告)号：US20100004549A1

    公开(公告)日：2010-01-07

    申请号：US12563713

    申请日：2009-09-21

    申请人： Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Xue

    发明人： Mark Kohls ,  Gordon Ian Rowlandson ,  Joel Xue

    IPC分类号： A61B5/0452

    CPC分类号： A61B5/0452

    摘要： The present disclosure includes a system and method of detecting LQTS in a patient by comparing a collected set of ECG data from the patient to a plurality of databases of collected ECG data. The plurality of databases will include a database containing previous ECGs from the patient, a known acquired LQTS characteristics database, and a known genetic LQTS characteristics database. Comparing the patients ECG to these databases will facilitate the detection of such occurrences as changes in QT interval from success of ECGs, changes in T-wave morphology, changes in U-wave morphology and can match known genetic patterns of LQTS. The system and method is sensitive to patient gender and ethnicity, as these factors have been shown to effect LQTS, and is furthermore capable of matching a QT duration to a database of drug effects. The system and method is also easily integrated into current ECG management systems and storage devices.

    摘要翻译： 本公开包括通过将收集的来自患者的ECG数据集合到收集的ECG数据的多个数据库来检测患者中的LQTS的系统和方法。 多个数据库将包括包含来自患者的先前ECG，已知获得的LQTS特征数据库和已知遗传LQTS特征数据库的数据库。 将患者心电图与这些数据库进行比较将有助于检测这些事件的发生，如ECG的成功，T波形态的变化，U波形态的变化以及与LQTS的已知遗传模式相匹配的QT间期变化。 该系统和方法对患者的性别和种族敏感，因为这些因素已经显示出影响LQTS，并且还能够将QT持续时间与药物效应数据库相匹配。 该系统和方法也很容易集成到当前的ECG管理系统和存储设备中。

    Method and apparatus for analysis of non-invasive cardiac parameters
    4.
    发明申请
    Method and apparatus for analysis of non-invasive cardiac parameters 审中-公开
    非侵入性心脏参数分析方法和装置

    公开(公告)号：US20050234353A1

    公开(公告)日：2005-10-20

    申请号：US10824950

    申请日：2004-04-15

    申请人： Joel Xue ,  G. Rowlandson ,  David Albert

    发明人： Joel Xue ,  G. Rowlandson ,  David Albert

    IPC分类号： A61B5/04 ,  A61B5/0402 ,  A61B5/0452 ,  A61B5/0472

    CPC分类号： A61B5/04011 ,  A61B5/0452 ,  A61B5/0472

    摘要： Method and apparatus for assessing a patient's cardiac vulnerability to sudden cardiac death. The method can include defining a relationship between depolarization and repolarization, determining a first value representative of the relationship for a first beat, determining a second value representative of the relationship for a second beat, and analyzing variation of the first value and the second value to assess the patient's cardiac vulnerability to sudden cardiac death.

    摘要翻译： 评估患者心脏猝死心脏易感性的方法和装置。 所述方法可以包括定义去极化和复极化之间的关系，确定表示第一节拍的关系的第一值，确定代表第二节拍的关系的第二值，以及分析第一值和第二值的变化 评估患者的心脏易感性，导致心源性猝死。

    Method and apparatus for detecting cardiac repolarization abnormality
    6.
    发明申请
    Method and apparatus for detecting cardiac repolarization abnormality 有权
    检测心脏复极异常的方法和装置

    公开(公告)号：US20050234357A1

    公开(公告)日：2005-10-20

    申请号：US10825494

    申请日：2004-04-15

    申请人： Joel Xue ,  G. Rowlandson ,  David Albert

    发明人： Joel Xue ,  G. Rowlandson ,  David Albert

    IPC分类号： A61B5/0402 ,  A61B5/0452

    CPC分类号： A61B5/04525 ,  A61B5/726

    摘要： Method and apparatus for detecting cardiac repolarization abnormality using at least one electrocardiogram signal. The at least one electrocardiogram signal can be obtained from any number of continuous or non-continuous windows. The method can include deriving a total quantity of representative beats of the at least one electrocardiogram signal. At least one morphology shape descriptor can be used to determine a total quantity of values representing the total quantity of representative beats. Data corresponding to at least some of the total quantity of values can be used to assess cardiac repolarization abnormality.

    摘要翻译： 使用至少一个心电图信号检测心脏复极异常的方法和装置。 可以从任意数量的连续或非连续窗口获得至少一个心电图信号。 该方法可以包括导出至少一个心电图信号的代表性搏动的总量。 可以使用至少一个形态描述符来确定表示代表性节拍的总量的总量的数量。 可以使用对应于总量值中的至少一些的数据来评估心脏复极化异常。

    Determination of cellular electrical potentials
    8.
    发明授权
    Determination of cellular electrical potentials 有权
    细胞电位的测定

    公开(公告)号：US09370310B2

    公开(公告)日：2016-06-21

    申请号：US11654922

    申请日：2007-01-18

    申请人： Yao Chen ,  Kai Thomenius ,  Yongsheng Yang ,  Fei Teng ,  Yong Zhang ,  Jian Zhou ,  Joel Xue

    发明人： Yao Chen ,  Kai Thomenius ,  Yongsheng Yang ,  Fei Teng ,  Yong Zhang ,  Jian Zhou ,  Joel Xue

    IPC分类号： A61B5/0402 ,  A61B6/00 ,  A61B5/00 ,  A61B8/08

    CPC分类号： A61B5/0402 ,  A61B5/04028 ,  A61B5/725 ,  A61B5/7278 ,  A61B5/742 ,  A61B6/503 ,  A61B8/0883

    摘要： A method is provided for determining cellular electrical potentials using a state estimator. The state estimator is generated using at least an electrical source model and an electrical conduction model. One or more parameters or states of the state estimator are adjusted based on a measured electrocardiographic and/or a measured body-surface-potential signal. The electrical potential of one or more cells is determined based on the one or more adjusted parameters or states. In one aspect of the present technique, one or more representations of an organ comprising the one or more cells is generated such that the electrical potential or its deriving characteristic of the one or more cells is visually indicated.

    摘要翻译： 提供了一种使用状态估计器来确定细胞电位的方法。 状态估计器使用至少一个电源模型和电传导模型来产生。 基于测量的心电图和/或测量的体表电位信号来调整状态估计器的一个或多个参数或状态。 基于一个或多个调整的参数或状态来确定一个或多个单元的电位。 在本技术的一个方面，生成包含一个或多个细胞的器官的一个或多个表示，使得在视觉上指示一个或多个细胞的电位或其导出特征。

    Method and apparatus for determining alternans data of an ECG signal
    9.
    发明申请
    Method and apparatus for determining alternans data of an ECG signal 有权
    用于确定ECG信号的交替数据的方法和装置

    公开(公告)号：US20050234363A1

    公开(公告)日：2005-10-20

    申请号：US10825495

    申请日：2004-04-15

    申请人： Joel Xue

    发明人： Joel Xue

    IPC分类号： A61B5/0402 ,  A61B5/0452

    CPC分类号： A61B5/0452

    摘要： Method and apparatus for determining alternans data of an ECG signal. The method can include determining at least one value representing at least one morphology feature of each beat of the ECG signal and generating a set of data points based on a total quantity of values and a total quantity of beats. The data points can each include a first value determined using a first mathematical function and a second value determined using a second mathematical function. The method can also include several preprocessing algorithms to improve the signal to noise ratio. The method can also include separating the data points into a first group of points and a second group of points and generating a feature map by plotting the first group of points and the second group of points in order to assess an alternans pattern of variation. The feature map can be analyzed by statistical tests to determine the significance difference between groups and clusters.

    摘要翻译： 用于确定ECG信号的交替数据的方法和装置。 该方法可以包括确定表示ECG信号的每个节拍的至少一个形态特征的至少一个值，并且基于总的总量和总搏动次数生成一组数据点。 数据点可以各自包括使用第一数学函数确定的第一值和使用第二数学函数确定的第二值。 该方法还可以包括几种预处理算法来提高信噪比。 该方法还可以包括将数据点分成第一组点和第二组点，并通过绘制第一组点和第二组点来生成特征图，以便评估交替变化模式。 可以通过统计检验来分析特征图，以确定组与群集之间的显着性差异。