公开(公告)号：US09572940B2

公开(公告)日：2017-02-21

申请号：US13701957

申请日：2011-06-09

申请人： Mark Philip Horlock

发明人： Mark Philip Horlock

IPC分类号： A61M5/315 ,  A61M5/31

CPC分类号： A61M5/31501 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31568 ,  A61M5/31585 ,  A61M2005/3125 ,  A61M2005/3151

摘要： A drive assembly for a medication delivery device is provided which is switchable from an operational state to a resetting state and which comprises: a housing having a proximal end and a distal end, a drive member adapted to be rotated with respect to the housing, and a stop member adapted to prevent rotational movement of the drive member in a first direction with respect to the housing and to permit rotational movement of the drive member in a second direction with respect to the housing, the second direction being opposite to the first direction. In the operational state of the drive assembly the stop member is held in engagement with the drive member, and for switching into the resetting state of the drive assembly the stop member is enabled to disengage from the drive member caused by gravity due to the weight of the stop member. Moreover, in the operational state of the drive assembly the drive member may be held in engagement with a rotation member, and for switching into the resetting state of the drive assembly the drive member may be enabled to disengage from the rotation member caused by gravity due to the weight of the drive member.

摘要翻译： 提供了一种用于药物输送装置的驱动组件，其可从操作状态切换到复位状态，其包括：具有近端和远端的壳体，适于相对于壳体旋转的驱动构件，以及 止动构件，其适于防止驱动构件相对于壳体在第一方向上的旋转运动，并且允许驱动构件相对于壳体沿第二方向旋转运动，第二方向与第一方向相反。 在驱动组件的操作状态下，止动构件保持与驱动构件接合，并且为了切换到驱动组件的复位状态，止动构件能够由于重力而与驱动构件脱离， 停止成员。 此外，在驱动组件的操作状态下，驱动构件可以被保持与旋转构件接合，并且为了切换到驱动组件的复位状态，驱动构件可能能够由重力引起的与旋转构件脱离 达到驱动构件的重量。

公开(公告)号：US20130211342A1

公开(公告)日：2013-08-15

申请号：US13701969

申请日：2011-06-09

申请人： Steffen Raab ,  Mark Philip Horlock ,  Stephen David Butler

发明人： Steffen Raab ,  Mark Philip Horlock ,  Stephen David Butler

IPC分类号： A61M5/315

CPC分类号： A61M5/31511 ,  A61M5/24 ,  A61M5/31543 ,  A61M5/3155 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31555 ,  A61M5/3158 ,  A61M5/31583 ,  A61M5/31585

摘要： An assembly for a drug delivery device is provided, comprising a housing, a rotation member adapted and arranged to be rotated in a first and in a second rotational direction with respect to the housing in an operational mode of the assembly, a drive member which is configured to mechanically cooperate with the rotation member such that the drive member follows rotation of the rotation member when the rotation member is rotated in the second rotational direction and such that the rotation member rotates with respect to the drive member when the rotation member is rotated in the first rotational direction, and a piston rod. The assembly further comprises at least one biasing member which is adapted and arranged to provide a force tending to bring the rotation member and the drive member out of mechanical cooperation in the operational mode. The assembly is switchable from the operational mode into a reset mode. For switching from the operational mode into the reset mode, the biasing member is configured to drive a relative axial movement between the drive member and the rotation member such that the rotation member and the drive member are brought out of mechanical cooperation. Furthermore, a drug delivery device is provided.

摘要翻译： 提供了一种用于药物输送装置的组件，包括壳体，旋转构件，其适于并布置成在组件的操作模式下相对于壳体在第一和第二旋转方向上旋转;驱动构件， 被构造成与所述旋转构件机械配合，使得当所述旋转构件沿所述第二旋转方向旋转时，所述驱动构件沿着所述旋转构件的旋转，并且使得当所述旋转构件旋转时所述旋转构件相对于所述驱动构件旋转 第一旋转方向和活塞杆。 该组件还包括至少一个偏置构件，该至少一个偏置构件适于并布置成提供趋向于使操作模式中的旋转构件和驱动构件脱离机械协作的力。 组件可以从操作模式切换到复位模式。 为了从操作模式切换到复位模式，偏置构件被构造成驱动驱动构件和旋转构件之间的相对轴向运动，使得旋转构件和驱动构件脱离机械协作。 此外，提供了药物输送装置。

公开(公告)号：US20130204205A1

公开(公告)日：2013-08-08

申请号：US13701957

申请日：2011-06-09

申请人： Mark Philip Horlock

发明人： Mark Philip Horlock

IPC分类号： A61M5/315

CPC分类号： A61M5/31501 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31568 ,  A61M5/31585 ,  A61M2005/3125 ,  A61M2005/3151

摘要： A drive assembly for a medication delivery device is provided which is switchable from an operational state to a resetting state and which comprises: a housing having a proximal end and a distal end, a drive member adapted to be rotated with respect to the housing, and a stop member adapted to prevent rotational movement of the drive member in a first direction with respect to the housing and to permit rotational movement of the drive member in a second direction with respect to the housing, the second direction being opposite to the first direction. In the operational state of the drive assembly the stop member is held in engagement with the drive member, and for switching into the resetting state of the drive assembly the stop member is enabled to disengage from the drive member caused by gravity due to the weight of the stop member. Moreover, in the operational state of the drive assembly the drive member may be held in engagement with a rotation member, and for switching into the resetting state of the drive assembly the drive member may be enabled to disengage from the rotation member caused by gravity due to the weight of the drive member.

摘要翻译： 提供了一种用于药物输送装置的驱动组件，其可从操作状态切换到复位状态，其包括：具有近端和远端的壳体，适于相对于壳体旋转的驱动构件，以及 止动构件，其适于防止驱动构件相对于壳体在第一方向上的旋转运动，并且允许驱动构件相对于壳体沿第二方向旋转运动，第二方向与第一方向相反。 在驱动组件的操作状态下，止动构件保持与驱动构件接合，并且为了切换到驱动组件的复位状态，止动构件能够由于重力而与驱动构件脱离， 停止成员。 此外，在驱动组件的操作状态下，驱动构件可以被保持与旋转构件接合，并且为了切换到驱动组件的复位状态，驱动构件可能能够由重力引起的与旋转构件脱离 达到驱动构件的重量。

公开(公告)号：US09408977B2

公开(公告)日：2016-08-09

申请号：US13701943

申请日：2011-06-09

申请人： Stephen David Butler ,  Mark Philip Horlock

发明人： Stephen David Butler ,  Mark Philip Horlock

IPC分类号： A61M5/315 ,  F16H25/12

CPC分类号： A61M5/31528 ,  A61M5/31535 ,  A61M5/31548 ,  A61M5/3155 ,  A61M5/31551 ,  A61M5/31555 ,  A61M5/31583 ,  A61M5/31585 ,  A61M5/31593 ,  F16H25/12 ,  Y10T74/18576

摘要： The drive mechanism comprises a drive member inside a housing, a rotation member and a dose member. The drive member is rotatable with respect to the housing. The rotation member is also rotatable and unidirectionally rotationally engaged with the drive member. The dose member is able to move along a set/deliver path between a first axial position and a second axial position in either direction or to move along a cancel path from the second axial position to the first axial position. An engagement of the dose member with the rotation member causes the rotation member to rotate when the dose member is moved along the set/deliver path. The drive member is not rotated when the dose member is moved along the cancel path. A button in/out spline can be provided for the set/deliver path and a cancel spline for the cancel path.

摘要翻译： 驱动机构包括在壳体内的驱动构件，旋转构件和剂量构件。 驱动构件可相对于壳体旋转。 旋转构件也可旋转并且与驱动构件单向旋转地接合。 剂量构件能够沿着任一方向上的第一轴向位置和第二轴向位置之间的设定/传送路径移动或者沿着从第二轴向位置到第一轴向位置的取消路径移动。 当剂量构件沿着设定/输送路径移动时，剂量构件与旋转构件的接合使得旋转构件旋转。 当剂量构件沿取消路径移动时，驱动构件不旋转。 可以为设置/传递路径提供按钮输入/输出样条线，并为取消路径提供取消样条线。

公开(公告)号：US20130190697A1

公开(公告)日：2013-07-25

申请号：US13702808

申请日：2011-06-09

申请人： Steffen Raab ,  Christopher James Smith ,  Mark Philip Horlock ,  Stephen David Butler

发明人： Steffen Raab ,  Christopher James Smith ,  Mark Philip Horlock ,  Stephen David Butler

IPC分类号： A61M5/315

CPC分类号： A61M5/31543 ,  A61M5/24 ,  A61M5/3155 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31555 ,  A61M5/3158 ,  A61M5/31583 ,  A61M5/31585

摘要： A drive mechanism for a drug delivery device which can be switched between a normal operation state and a reset state comprises of a housing having a proximal end and a distal end, a rotation member which is adapted to rotate in a first direction and in a second direction with respect to the housing, a drive member, wherein in the normal operation state the rotation member is coupled with the drive member so that the drive member follows rotational movement of the rotation member in the second direction, a piston rod, wherein in the normal operation state the piston rod is displaced in a distal direction with respect to the housing when the drive member rotates in the second direction with respect to the housing, a stop member, wherein in the normal operation state the stop member is coupled with the drive member so that the stop member prevents rotational movement of the drive member with respect to the housing in the first direction, and a separation member for switching the operation state, the separation member being adapted to move the stop member and the drive member in the distal direction with respect to the housing when the normal operation state is switched to the reset state, thereby decoupling the stop member and the drive member and decoupling the drive member and the rotation member.

摘要翻译： 用于可在正常操作状态和复位状态之间切换的药物输送装置的驱动机构包括具有近端和远端的壳体，适于沿第一方向旋转的旋转构件 方向相对于壳体，驱动构件，其中在正常操作状态下，旋转构件与驱动构件联接，使得驱动构件沿第二方向旋转构件的旋转运动，活塞杆，其中在 当驱动构件相对于壳体沿第二方向旋转时，活塞杆相对于壳体在远端方向上移位，其中在正常操作状态下，止动构件与驱动器联接 使得止动构件防止驱动构件相对于壳体沿第一方向的旋转运动，以及用于切换操作的分离构件 n状态，当正常操作状态切换到复位状态时，分离构件适于在远端方向上相对于壳体移动止动构件和驱动构件，从而使止动构件和驱动构件分离， 驱动构件和旋转构件。

公开(公告)号：USRE46814E1

公开(公告)日：2018-05-01

申请号：US14677006

申请日：2015-04-02

申请人： Christopher James Smith ,  Michael Heald ,  Stephen David Butler ,  Mark Philip Horlock

发明人： Christopher James Smith ,  Michael Heald ,  Stephen David Butler ,  Mark Philip Horlock

IPC分类号： A61M5/315

CPC分类号： A61M5/315

摘要： A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing. In the resetting state of the device the coupling means is disengaged from the conversion element under force of the resilient member, the conversion element thereby being allowed to rotate with respect to the housing and thereby allowing a resetting of the device.

公开(公告)号：US09555195B2

公开(公告)日：2017-01-31

申请号：US13701995

申请日：2011-06-09

申请人： Christopher James Smith ,  Stephen David Butler ,  Mark Philip Horlock

发明人： Christopher James Smith ,  Stephen David Butler ,  Mark Philip Horlock

IPC分类号： A61M5/142 ,  A61M5/315 ,  F16H19/02

CPC分类号： A61M5/31551 ,  A61M5/142 ,  A61M5/31536 ,  A61M5/31555 ,  A61M5/31585 ,  A61M2205/581 ,  A61M2205/582 ,  F16H19/02 ,  Y10T74/18568

摘要： A drive assembly for a drug delivery device comprises a rotation member being configured to be rotated in a first direction during setting of a dose of a drug and to be rotated in a second direction during delivery of the dose, a drive component being configured to follow rotational movement of the rotation member in the second direction during delivery of the dose and a stop member being configured to prevent rotational movement of the drive component in the first direction. The drive component comprises a first drive part and a second drive part, coupled to each other such that relative rotational movement of the first and second drive parts is prevented and relative axial movement is permitted.

摘要翻译： 用于药物递送装置的驱动组件包括旋转构件，其构造成在药物剂量的设定期间沿第一方向旋转并且在剂量递送期间沿第二方向旋转，驱动部件被配置为跟随 在剂量输送期间旋转构件在第二方向上的旋转运动，以及止动构件被构造成防止驱动构件在第一方向上的旋转运动。 驱动部件包括彼此连接的第一驱动部分和第二驱动部分，从而防止第一和第二驱动部件的相对旋转运动并允许相对的轴向移动。

公开(公告)号：US09498576B2

公开(公告)日：2016-11-22

申请号：US13702808

申请日：2011-06-09

申请人： Steffen Raab ,  Christopher James Smith ,  Mark Philip Horlock ,  Stephen David Butler

发明人： Steffen Raab ,  Christopher James Smith ,  Mark Philip Horlock ,  Stephen David Butler

IPC分类号： A61M5/315 ,  A61M5/24

CPC分类号： A61M5/31543 ,  A61M5/24 ,  A61M5/3155 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31555 ,  A61M5/3158 ,  A61M5/31583 ,  A61M5/31585

摘要： A drive mechanism for a drug delivery device which can be switched between a normal operation state and a reset state comprises of a housing having a proximal end and a distal end, a rotation member which is adapted to rotate in a first direction and in a second direction with respect to the housing, a drive member, wherein in the normal operation state the rotation member is coupled with the drive member so that the drive member follows rotational movement of the rotation member in the second direction, a piston rod, wherein in the normal operation state the piston rod is displaced in a distal direction with respect to the housing when the drive member rotates in the second direction with respect to the housing, a stop member, wherein in the normal operation state the stop member is coupled with the drive member so that the stop member prevents rotational movement of the drive member with respect to the housing in the first direction, and a separation member for switching the operation state, the separation member being adapted to move the stop member and the drive member in the distal direction with respect to the housing when the normal operation state is switched to the reset state, thereby decoupling the stop member and the drive member and decoupling the drive member and the rotation member.

摘要翻译： 用于可在正常操作状态和复位状态之间切换的药物输送装置的驱动机构包括具有近端和远端的壳体，适于沿第一方向旋转的旋转构件 方向相对于壳体，驱动构件，其中在正常操作状态下，旋转构件与驱动构件联接，使得驱动构件沿第二方向旋转构件的旋转运动，活塞杆，其中在 当驱动构件相对于壳体沿第二方向旋转时，活塞杆相对于壳体在远端方向上移位，其中在正常操作状态下，止动构件与驱动器联接 使得止动构件防止驱动构件相对于壳体沿第一方向的旋转运动，以及用于切换操作的分离构件 n状态，当正常操作状态切换到复位状态时，分离构件适于在远端方向上相对于壳体移动止动构件和驱动构件，从而使止动构件和驱动构件分离， 驱动构件和旋转构件。

公开(公告)号：US08882723B2

公开(公告)日：2014-11-11

申请号：US13702812

申请日：2011-06-09

申请人： Christopher James Smith ,  Stephen David Butler ,  Mark Philip Horlock

发明人： Christopher James Smith ,  Stephen David Butler ,  Mark Philip Horlock

IPC分类号： A61M5/00 ,  A61M5/315

CPC分类号： A61M5/31528 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31585

摘要： A drive member and a rotation member are rotatable with respect to a housing. A stop member is rotationally locked with the housing. Clutches unidirectionally rotationally engage the drive member with the rotation member and with the stop member when a unit is attached to the housing. A separating member is disposed between the rotation member and the stop member. The separating member causes a separation of the rotation member, the drive member and the stop member when the unit is removed. A coupling feature of the separating member is provided to engage the unit and to move the separating member when the unit is being attached to the housing or is being removed.

摘要翻译： 驱动构件和旋转构件可相对于壳体旋转。 止动构件与壳体旋转地锁定。 当单元附接到壳体时，离合器单向地旋转地与驱动构件旋转地接合旋转构件和止动构件。 分离构件设置在旋转构件和止动构件之间。 当单元被移除时，分离构件导致旋转构件，驱动构件和止动构件的分离。 提供分离构件的联接特征以接合单元并且当单元附接到壳体或正在移除时移动分离构件。

公开(公告)号：US20130190719A1

公开(公告)日：2013-07-25

申请号：US13702816

申请日：2011-06-09

申请人： Christopher James Smith ,  Mark Philip Horlock ,  Stephen David Butler

发明人： Christopher James Smith ,  Mark Philip Horlock ,  Stephen David Butler

IPC分类号： A61M5/315

CPC分类号： A61M5/31568 ,  A61M5/24 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31585 ,  A61M2005/3125 ,  A61M2005/3126

摘要： A drug delivery device is proposed, which comprises a housing, a drive member which is movably retained within the housing, a piston rod which is operatively coupled to the drive member, wherein the drug delivery device is configured to convert movement of the drive member with respect to the housing into movement of the piston rod with respect to the drive member, wherein a surface of the drive member is provided with one or a plurality of indication elements, and wherein the drug delivery device is adapted to display at least one of the indication elements through the housing. Furthermore it is proposed to use a single member in a drug delivery device for driving movement of a piston rod of the device and for displaying dose related information to a user of the device.

摘要翻译： 提出了一种药物输送装置，其包括壳体，可移动地保持在壳体内的驱动构件，可操作地联接到驱动构件的活塞杆，其中药物输送装置构造成将驱动构件的运动转换为 相对于驱动构件，活塞杆相对于驱动构件的运动相对于壳体，其中驱动构件的表面设置有一个或多个指示元件，并且其中药物输送装置适于显示至少一个 指示元素通过住房。 此外，建议在药物输送装置中使用单个构件来驱动装置的活塞杆的运动并向用户显示剂量相关信息。