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    Chimeric antibodies
    1.
    发明授权
    Chimeric antibodies 失效
    嵌合抗体

    公开(公告)号：US5169939A

    公开(公告)日：1992-12-08

    申请号：US296375

    申请日：1989-04-09

    申请人： Malcolm L. Gefter ,  Mark Ptashne ,  Jacqueline Sharon

    发明人： Malcolm L. Gefter ,  Mark Ptashne ,  Jacqueline Sharon

    IPC分类号： C07K16/46 ,  C12N15/62

    CPC分类号： C07K16/468 ,  C12N15/62 ,  C07K2319/00 ,  C07K2319/02

    摘要： Chimeric antibodies comprised of the variable region of an antibody chain contiguous with a polypeptide other than the constant region of that antibody chain are disclosed. Such chimeric antibodies can be comprised of the variable region of a chain of an immunoglobulin of selected specificity and an extrinsic polypeptide. In addition to the variable region of a chain of an immunoglobulin of selected specifity and an extrinsic polypeptide, the chimeric antibodies can include at least a portion of the constant region of an immunoglobFUNDING SOURCESThe work described herein was supported by grants from the National Institutes of Health, the American Cancer Society and the Damon Runyon--Walter Winchell Cancer Fund.

    摘要翻译： 公开了由与抗体链恒定区以外的多肽连接的抗体链的可变区组成的嵌合抗体。 这样的嵌合抗体可以由所选特异性的免疫球蛋白链的可变区和外在多肽组成。 除了所选特异性的免疫球蛋白链的可变区和外在多肽之外，嵌合抗体可以包括免疫球蛋白链的恒定区的至少一部分。

    Transcriptional activator comprising a short hydrophobic activation peptide
    2.
    发明授权
    Transcriptional activator comprising a short hydrophobic activation peptide 失效
    包含短疏水活化肽的转录激活剂

    公开(公告)号：US07087711B2

    公开(公告)日：2006-08-08

    申请号：US09943944

    申请日：2001-08-31

    申请人： Mark Ptashne ,  Xiangyang Lu ,  Yibing Wu

    发明人： Mark Ptashne ,  Xiangyang Lu ,  Yibing Wu

    IPC分类号： C07K19/00 ,  C07K14/00

    CPC分类号： C07K14/395 ,  C07K2319/00 ,  C12N15/1055 ,  C12N15/63

    摘要： The present invention describes novel transcriptional activators and activation systems. The activators of the present invention comprise a DNA binding moiety linked to a short peptide of novel sequence. Preferably, the peptide is substantially hydrophobic. Preferred peptides include at least one aromatic amino acid. The present invention also provides improved transcriptional activation systems, useful for the identification and characterization of protein—protein interactions. The invention also describes the production and use of certain TBP mutants that enhance transcriptional activation by some activators.

    摘要翻译： 本发明描述了新的转录激活子和活化系统。 本发明的活化剂包含连接到新序列的短肽的DNA结合部分。 优选地，肽是基本上疏水的。 优选的肽包括至少一种芳族氨基酸。 本发明还提供改进的转录激活系统，其可用于鉴定和表征蛋白质 - 蛋白质相互作用。 本发明还描述了通过一些活化剂增强转录激活的某些TBP突变体的生产和使用。