公开(公告)号：US08108943B2

公开(公告)日：2012-01-31

申请号：US12324693

申请日：2008-11-26

申请人： Mark S. Anderson

发明人： Mark S. Anderson

IPC分类号： G01Q60/06

CPC分类号： G01Q30/02 ,  G01J3/44 ,  G01N21/648 ,  G01N21/658 ,  G01Q60/06

摘要： There is provided in one embodiment of the invention a method for analyzing a sample material using surface enhanced spectroscopy. The method comprises the steps of imaging the sample material with an atomic force microscope (AFM) to select an area of interest for analysis, depositing nanoparticles onto the area of interest with an AFM tip, illuminating the deposited nanoparticles with a spectrometer excitation beam, and disengaging the AFM tip and acquiring a localized surface enhanced spectrum. The method may further comprise the step of using the AFM tip to modulate the spectrometer excitation beam above the deposited nanoparticles to obtain improved sensitivity data and higher spatial resolution data from the sample material. The invention further comprises in one embodiment a system for analyzing a sample material using surface enhanced spectroscopy.

摘要翻译： 在本发明的一个实施例中提供了一种使用表面增强光谱分析样品材料的方法。 该方法包括以下步骤：用原子力显微镜（AFM）对样品材料进行成像，以选择用于分析的感兴趣区域，用AFM尖端将纳米颗粒沉积到感兴趣区域上，用光谱仪激发束照射沉积的纳米颗粒，以及 脱离AFM尖端并获取局部表面增强光谱。 该方法还可以包括使用AFM尖端来调制沉积的纳米粒子上方的光谱仪激发光束以获得改进的灵敏度数据和来自样品材料的较高空间分辨率数据的步骤。 本发明还在一个实施方案中包括使用表面增强光谱分析样品材料的系统。

公开(公告)号：US4856612A

公开(公告)日：1989-08-15

申请号：US154676

申请日：1988-02-10

申请人： James T. Clevenger, Jr. ,  Dale A. Ashcroft ,  Richard P. Strosser ,  Mark S. Anderson

发明人： James T. Clevenger, Jr. ,  Dale A. Ashcroft ,  Richard P. Strosser ,  Mark S. Anderson

IPC分类号： B60K28/04 ,  B60R22/48

CPC分类号： B60K28/04 ,  B60R22/48 ,  B60R2022/4816 ,  B60R2022/4858 ,  B60R2022/4891

摘要： A method of controlling the operation of a loader to encourage the use of an operator restraint mechanism is disclosed wherein a first signal is generated by a seat sensor to indicate the presence of the operator in the operator seat and a second signal is generated by a sensor in the operator restraint mechanism to indicate use of the mechanism. The hydraulic system will not be enabled unless the second signal is generated immediately subsequent to the generation of the first signal. Unless the first and second signals are generated in the proper sequence, the starting of the engine will also be disabled. The generation of first and second inverse signals, indicating the lack of the presence of the operator in the seat and the disengagement of the operator restraint mechanism, respectively, will disable the loader hydraulic system. A delay is provided to permit the operator to vacate the seat for a short period of time without having to resequence the generation of the first and second signals to enable the loader hydraulic system.

摘要翻译： 公开了一种控制装载机的操作以促进使​​用操作者约束机构的方法，其中由座椅传感器产生第一信号以指示操作员在操作者座椅中的存在，并且传感器产生第二信号 在操作员约束机制中指示使用机制。 除非产生第一个信号之后立即产生第二个信号，液压系统将不启用。 除非第一和第二信号以适当的顺序生成，否则引擎的启动也将被禁用。 第一和第二反向信号的产生，分别表示操作者在座椅中的存在以及操作者约束机构的脱离，将使装载机液压系统失效。 提供延迟以允许操作者在短时间内腾出座椅，而不必重新生成第一和第二信号以使装载机液压系统成为可能。

公开(公告)号：US09005982B2

公开(公告)日：2015-04-14

申请号：US13703617

申请日：2011-06-10

申请人： Mark S. Anderson ,  Anthony K. Shum

发明人： Mark S. Anderson ,  Anthony K. Shum

IPC分类号： G01N33/00 ,  G01N33/48 ,  G01N33/50 ,  G01N33/68 ,  A01K67/027 ,  G01N33/564

CPC分类号： G01N33/6884 ,  A01K67/027 ,  A01K2227/101 ,  A01K2227/105 ,  A01K2227/106 ,  A01K2267/0325 ,  G01N33/564 ,  G01N2800/12 ,  G01N2800/50

摘要： The present disclosure is generally related to pulmonary autoantigens. The disclosure provides methods and kits for assessing whether a subject has or is predisposed to interstitial lung disease. Additionally the present disclosure provides methods of treatment and animal models of interstitial lung disease.

摘要翻译： 本公开一般涉及肺自身抗原。 本公开提供了用于评估受试者是否患有间质性肺病的方法和试剂盒。 此外，本公开提供了间质性肺疾病的治疗方法和动物模型。

公开(公告)号：US08649000B1

公开(公告)日：2014-02-11

申请号：US13277954

申请日：2011-10-20

申请人： Mark S Anderson

发明人： Mark S Anderson

IPC分类号： G01J3/00

CPC分类号： G01N21/65 ,  G01N2021/7789

摘要： Disclosed herein is a spectroscopic probe comprising at least one whispering gallery mode optical resonator disposed on a support, the whispering gallery mode optical resonator comprising a continuous outer surface having a cross section comprising a first diameter and a second diameter, wherein the first diameter is greater than the second diameter. A method of measuring a Raman spectrum and an Infra-red spectrum of an analyte using the spectroscopic probe is also disclosed.

摘要翻译： 本文公开了一种分光探针，其包括设置在支撑件上的至少一个耳语画廊模式光学谐振器，该耳语画廊模式光学谐振器包括具有包括第一直径和第二直径的横截面的连续外表面，其中第一直径较大 比第二个直径。 还公开了使用分光探针测量分析物的拉曼光谱和红外光谱的方法。

公开(公告)号：US20090249520A1

公开(公告)日：2009-10-01

申请号：US12324693

申请日：2008-11-26

申请人： Mark S. Anderson

发明人： Mark S. Anderson

IPC分类号： G12B21/06 ,  G01J3/44

CPC分类号： G01Q30/02 ,  G01J3/44 ,  G01N21/648 ,  G01N21/658 ,  G01Q60/06

摘要： There is provided in one embodiment of the invention a method for analyzing a sample material using surface enhanced spectroscopy. The method comprises the steps of imaging the sample material with an atomic force microscope (AFM) to select an area of interest for analysis, depositing nanoparticles onto the area of interest with an AFM tip, illuminating the deposited nanoparticles with a spectrometer excitation beam, and disengaging the AFM tip and acquiring a localized surface enhanced spectrum. The method may further comprise the step of using the AFM tip to modulate the spectrometer excitation beam above the deposited nanoparticles to obtain improved sensitivity data and higher spatial resolution data from the sample material. The invention further comprises in one embodiment a system for analyzing a sample material using surface enhanced spectroscopy.

摘要翻译： 在本发明的一个实施例中提供了一种使用表面增强光谱分析样品材料的方法。 该方法包括以下步骤：用原子力显微镜（AFM）对样品材料进行成像，以选择用于分析的感兴趣区域，用AFM尖端将纳米颗粒沉积到感兴趣区域上，用光谱仪激发束照射沉积的纳米颗粒;以及 脱离AFM尖端并获取局部表面增强光谱。 该方法还可以包括使用AFM尖端来调制沉积的纳米粒子上方的光谱仪激发光束以获得改进的灵敏度数据和来自样品材料的较高空间分辨率数据的步骤。 本发明还在一个实施方案中包括使用表面增强光谱分析样品材料的系统。

公开(公告)号：US06850323B2

公开(公告)日：2005-02-01

申请号：US10062081

申请日：2002-01-31

申请人： Mark S. Anderson

发明人： Mark S. Anderson

IPC分类号： B82B3/00 ,  G01J3/44 ,  G01N21/65 ,  G01Q60/24 ,  G01J3/30 ,  G02B21/00

CPC分类号： G01J3/44 ,  B82B3/00 ,  G01N21/658 ,  G01Q30/02 ,  Y10S977/863 ,  Y10S977/868

摘要： An atomic force microscope (AFM) tip is used to selectively produce surface enhanced Raman scattering (SERS) for localized Raman spectroscopy. Spectra of thin films, undetectable with a Raman microprobe spectrometer alone, are readily acquired in contact with a suitably gold-coated AFM tip. Similarly, an AFM tip is used to remove sample layers at the nanometer scale and subsequently serve as a SERS substrate for ultra-trace analysis. This demonstrates the interface of an AFM with a Raman spectrometer that provides increases sensitivity, selectivity and spatial resolution over a conventional Raman microprobe. An AFM guiding the SERS effect has the potential for targeted single molecule spectroscopy.

摘要翻译： 原子力显微镜（AFM）尖端用于选择性地产生用于局部拉曼光谱的表面增强拉曼散射（SERS）。 单独使用拉曼探针光谱仪检测不到的薄膜光谱很容易与适当的镀金AFM尖端接触。 类似地，使用AFM尖端去除纳米级的样品层，随后用作用于超痕量分析的SERS底物。 这表明AFM与拉曼光谱仪的接口，提供了比常规拉曼微探针提高灵敏度，选择性和空间分辨率。 引导SERS效应的AFM具有靶向单分子光谱的潜力。

公开(公告)号：US4844196A

公开(公告)日：1989-07-04

申请号：US219037

申请日：1988-07-14

申请人： James T. Clevenger, Jr. ,  Dale A. Ashcroft ,  Richard P. Strosser ,  Mark S. Anderson

发明人： James T. Clevenger, Jr. ,  Dale A. Ashcroft ,  Richard P. Strosser ,  Mark S. Anderson

IPC分类号： B60R22/48 ,  E02F9/24

CPC分类号： B60R22/48 ,  E02F9/24 ,  B60R2022/4816 ,  B60R2022/4858 ,  B60R2022/4891

摘要： A loader having hydraulically operated boom and bucket mechanisms controllable from the operator seat is disclosed wherein switches sense the presence of the operator in the seat and the buckling of the seat belt. An electronic controller is operably associated with the seat and belt switches and solenoid valves in the hydraulic system and the starter relay. The controller requires proper sequencing of the activation of the seat and belt switches before permitting the starter to be energized, thereby controlling the starting of the loader engine, or permitting the energizing of the hydraulic solenoid valves to control the flow of hydraulic fluid to the hydraulic cylinders for the boom and bucket. The controller also includes a delay associated with the seat switch so that a reactivation of the seat switch within the delayed period of time would allow the hydraulic system to operate without requiring a resequencing of the activation of the seat and belt switches.

公开(公告)号：US20130212720A1

公开(公告)日：2013-08-15

申请号：US13703617

申请日：2011-06-10

申请人： Mark S. Anderson ,  Anthony K. Shum

发明人： Mark S. Anderson ,  Anthony K. Shum

IPC分类号： G01N33/68

CPC分类号： G01N33/6884 ,  A01K67/027 ,  A01K2227/101 ,  A01K2227/105 ,  A01K2227/106 ,  A01K2267/0325 ,  G01N33/564 ,  G01N2800/12 ,  G01N2800/50

摘要： The present disclosure is generally related to pulmonary autoantigens. The disclosure provides methods and kits for assessing whether a subject has or is predisposed to interstitial lung disease. Additionally the present disclosure provides methods of treatment and animal models of interstitial lung disease.

摘要翻译： 本公开一般涉及肺自身抗原。 本公开提供了用于评估受试者是否患有间质性肺病的方法和试剂盒。 此外，本公开提供了间质性肺疾病的治疗方法和动物模型。

公开(公告)号：US20080289309A1

公开(公告)日：2008-11-27

申请号：US11883978

申请日：2006-02-08

申请人： Jackie R. Gust ,  Mark S. Anderson

发明人： Jackie R. Gust ,  Mark S. Anderson

IPC分类号： A01D34/24

CPC分类号： A01D69/025 ,  A01D69/00

摘要： This invention relates to a hybrid lawn mower powered by a fuel cell and an electrical storage system, both of which supply electric power to the drive wheels and cutting units of the mower. The electrical storage system comprises an ultracapacitor pack or a battery pack. The electric motor driving each cutting unit comprises a brushless motor having an integrated gear reduction stage. In addition, the motor includes an integrated electronics housing in which the electronics for controlling and powering the motor are packaged. The cutting units are lifted out of engagement with the ground by a lift and lower system comprising an electric/hydraulic actuator that is driven only during lifting of the cutting units. The cutting units are lowered by releasing fluid pressure in the lift and lower system and permitting the force of gravity to lower the cutting units.

摘要翻译： 本发明涉及一种由燃料电池供电的混合动力割草机和一种电力存储系统，两者都向驱动轮和割草机的切割装置提供电力。 电气存储系统包括超级电容器组件或电池组件。 驱动每个切割单元的电动机包括具有集成齿轮减速级的无刷电动机。 此外，电动机包括集成电子器件外壳，其中用于控制和供电电动机的电子器件被封装。 切割单元通过电梯和下部系统被提升离开与地面的接合，该系统包括仅在提升切割单元期间驱动的电动/液压致动器。 切割单元通过释放升降系统中的流体压力而降低，并允许重力降低切割单元。

公开(公告)号：US07328563B1

公开(公告)日：2008-02-12

申请号：US11478264

申请日：2006-06-29

申请人： Mark S. Anderson ,  Jackie R. Gust

发明人： Mark S. Anderson ,  Jackie R. Gust

IPC分类号： A01D69/00

CPC分类号： A01D34/47

摘要： A walk reel mower has a front mounted reel cutting unit and a rear handle. The operator pushes the handle towards the ground to lift the reel cutting unit off the ground prior to turning the walk reel mower around. When this occurs, the manner in which the reel cutting unit is supported in conjunction with the influence of gravity causes the reel cutting unit to pitch rearwardly relative to the frame of the walk reel mower. This change of orientation is used to close a switch which, in turn, initiates an automatic slow down of the mower to ease the task of turning the mower around. When a turn is completed and the cutting unit is dropped back down into engagement with the ground, the slow down is terminated and the ground speed resumes at whatever predetermined ground speed was previously selected by the operator.

摘要翻译： 步行式割草机具有前装卷轴切割装置和后手柄。 操作者将把手推向地面，以便在将步行卷线器割草机转动之前将卷轴切割单元从地面上提起。 当发生这种情况时，卷轴切割单元与重力的影响一起被支撑的方式使得卷轴切割单元相对于步行卷取机割草机的框架向后倾斜。 这种方向的改变用于关闭开关，这反过来又启动了割草机的自动减速，以缓解割草机周围的任务。 当转弯完成并且切割单元下降到与地面接合时，减速终止，并且地面速度以任何预先确定的地面速度恢复，由操作者先前选择。