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公开(公告)号:US20180202229A1
公开(公告)日:2018-07-19
申请号:US15409008
申请日:2017-01-18
申请人: Mark Wood
发明人: Mark Wood
CPC分类号: E06C7/14 , E04G21/005 , E06C1/18 , E06C7/16
摘要: A drywall compound storage system includes a ladder that has a topmost step. A drywall hawk is provided and drywall compound is positioned thereon. A support is provided and the support is selectively positioned on the ladder. The drywall hawk is selectively positioned on the support such that the drywall hawk is retained in a horizontal orientation. In this way the support inhibit the drywall compound from sliding off of the drywall hawk when the drywall hawk is set on the support.
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公开(公告)号:US09033975B2
公开(公告)日:2015-05-19
申请号:US13781222
申请日:2013-02-28
申请人: Dane Seddon , Sean Fleury , Mark Wood , Peter Dayton
发明人: Dane Seddon , Sean Fleury , Mark Wood , Peter Dayton
CPC分类号: A61B18/1492 , A61B18/14 , A61B18/1482 , A61B2017/003 , A61B2017/00305 , A61B2017/00314 , A61B2017/00323
摘要: Embodiments of the disclosure include devices and systems for using an end effector. In an embodiment, a medical device may include an articulation section. The articulation section may be operatively associated with an elongate articulation member configured to move the articulation section, wherein the articulation section can be configured to receive part of a conductive member. The medical device may also include an end effector. The end effector may include an electrode and a non-conductive section encasing a junction between the electrode and the conductive member, wherein the non-conductive section can be moveably coupled to the articulation section and can be fixedly coupled to the elongate articulation member.
摘要翻译: 本公开的实施例包括用于使用末端执行器的装置和系统。 在一个实施例中,医疗装置可以包括关节运动部分。 铰接部分可以与构造成移动关节运动部分的细长关节运动构件可操作地相关联,其中关节运动部分可以构造成容纳导电部件的一部分。 医疗装置还可以包括端部执行器。 末端执行器可以包括电极和非导电部分,其包围电极和导电构件之间的接合部,其中非导电部分可以可移动地联接到关节运动部分并且可以固定地联接到细长的关节部件。
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公开(公告)号:US08603802B2
公开(公告)日:2013-12-10
申请号:US13144470
申请日:2009-12-23
申请人: Wing L. Sung , Mark Wood , Fang Huang
发明人: Wing L. Sung , Mark Wood , Fang Huang
CPC分类号: D01C1/02
摘要: A method of extracting fibers from decorticated plant bast skin involves pre-treating decorticated plant bast skin of a fiber plant with an aqueous solution containing trisodium citrate having a pH in a range of about 8-14 at a temperature of about 90° C. or less; and subsequently treating recovered fibers with a protease at alkaline pH.
摘要翻译: 从脱皮的植物皮肤皮肤提取纤维的方法包括用约含有柠檬酸三钠的水溶液预处理纤维植物的脱皮植物皮肤,所述柠檬酸三钠在约90℃的温度下约为8-14℃,或 减; 并随后在碱性pH下用蛋白酶处理回收的纤维。
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公开(公告)号:US08511718B2
公开(公告)日:2013-08-20
申请号:US12787436
申请日:2010-05-26
申请人: Joseph Geiger , Michael Gerdes , Mark Wood , Anthony Zymroz, Jr.
发明人: Joseph Geiger , Michael Gerdes , Mark Wood , Anthony Zymroz, Jr.
IPC分类号: F16L41/00
CPC分类号: F16L5/00 , F24C3/126 , Y10T29/49963 , Y10T29/49968
摘要: A pipe and connector assembly of an appliance is provided. The assembly has a pipe for connecting to a fluid system of the appliance; a transition section fluidly connected to the pipe; a connector portion for connecting to the external fluid supply by way of a twisting motion between the external fluid supply and the connector portion; an anti-torque plate fixed rigidly to the transition section, the anti-torque plate having an engagement area; and a shoulder element for attaching the anti-torque plate to a chassis of the appliance. A shoulder portion of the shoulder element is positioned to engage the engagement area of the anti-torque plate such that movement of the anti-torque plate in a plane that is parallel to the twisting motion is restrained by the shoulder portion engaging the engagement area, and movement of the anti-torque plate is permitted along a length of the shoulder portion.
摘要翻译: 提供了一种器具的管道和连接器组件。 组件具有用于连接到器具的流体系统的管道; 流体连接到管道的过渡部分; 连接器部分,用于通过在外部流体供应源和连接器部分之间的扭转运动连接到外部流体供应源; 所述防扭矩板刚性地固定到所述过渡部分,所述防扭矩板具有接合区域; 以及用于将抗扭矩板附接到器具的底盘的肩部元件。 肩部元件的肩部被定位成与抗扭矩板的接合区域接合,使得抗扭矩板在平行于扭转运动的平面中的运动被接合接合区域的肩部限制, 并且允许沿着肩部的长度的抗扭矩板的移动。
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公开(公告)号:US20130123339A1
公开(公告)日:2013-05-16
申请号:US13697000
申请日:2011-05-12
申请人: James Heyes , Mark Wood , Alan Martin , Amy C.H. Lee , Adam Judge , Marjorie Robbins , Ian MacLachlan
发明人: James Heyes , Mark Wood , Alan Martin , Amy C.H. Lee , Adam Judge , Marjorie Robbins , Ian MacLachlan
IPC分类号: A61K31/713
CPC分类号: A61K31/713 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要: The present invention provides compositions and methods for the delivery of interfering RNAs such as siRNAs that silence APOB expression in cells such as liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells such as liver cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
摘要翻译: 本发明提供用于递送干扰RNA的组合物和方法,例如在细胞如肝细胞中沉默APOB表达的siRNA。 特别地,核酸 - 脂质颗粒提供了核酸的有效包封,并且将体内核酸的活性有效地递送到细胞例如肝细胞。 本发明的组合物是非常有效的,从而允许以相对低的剂量有效地击倒APOB。 此外,与本领域已知的组合物和方法相比,本发明的组合物和方法毒性低,并提供更大的治疗指数。
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公开(公告)号:US08420988B2
公开(公告)日:2013-04-16
申请号:US12786499
申请日:2010-05-25
申请人: Joseph Geiger , Michael Gerdes , Troy Wilson , Mark Wood , Anthony Zymroz, Jr.
发明人: Joseph Geiger , Michael Gerdes , Troy Wilson , Mark Wood , Anthony Zymroz, Jr.
摘要: A domestic appliance includes a control panel and a control panel mounting bracket which includes a frame shaped for being installed on a surface panel of a domestic appliance. The surface panel has an opening therein for receiving the frame. The frame has an open portion for receiving a control mount adhered over the open portion. The surface panel has a top surface and a bottom surface, and the frame has a main securing member having at least one tab extending therefrom. The tab is bendable along a line off-set from vertical such that when the tab is bent, it bears against the bottom surface of the surface panel to urge the frame against the surface panel.
摘要翻译: 家用电器包括控制面板和控制面板安装支架,该支架包括形状为安装在家用电器的表面面板上的框架。 表面板在其中具有用于接收框架的开口。 框架具有开口部分,用于接收粘附在开口部分上的控制装置。 表面板具有顶表面和底表面,并且框架具有主固定构件,其具有从其延伸的至少一个突出部。 标签可以沿着垂直偏离的线弯曲,使得当突片弯曲时,该突片抵靠在表面板的底表面上以将框架推靠在表面板上。
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公开(公告)号:US20130064894A1
公开(公告)日:2013-03-14
申请号:US13599220
申请日:2012-08-30
申请人: Alan Martin , James Heyes , Mark Wood
发明人: Alan Martin , James Heyes , Mark Wood
IPC分类号: A61K48/00 , A61K47/28 , A61K9/14 , A61K47/22 , A61K31/713 , C07D319/06
CPC分类号: C07D319/06 , A61K9/127 , A61K9/1272 , A61K9/14 , A61K9/5123 , A61K31/713 , A61K47/22 , A61K47/28 , A61K48/0033 , B82Y5/00 , C12N15/88 , Y10S977/773 , Y10S977/906 , Y10T428/2982
摘要: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
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公开(公告)号:US20110291403A1
公开(公告)日:2011-12-01
申请号:US12787436
申请日:2010-05-26
申请人: Joseph Geiger , Michael Gerdes , Mark Wood , Anthony Zymroz, JR.
发明人: Joseph Geiger , Michael Gerdes , Mark Wood , Anthony Zymroz, JR.
CPC分类号: F16L5/00 , F24C3/126 , Y10T29/49963 , Y10T29/49968
摘要: A pipe and connector assembly of an appliance is provided. The assembly has a pipe for connecting to a fluid system of the appliance; a transition section fluidly connected to the pipe; a connector portion for connecting to the external fluid supply by way of a twisting motion between the external fluid supply and the connector portion; an anti-torque plate fixed rigidly to the transition section, the anti-torque plate having an engagement area; and a shoulder element for attaching the anti-torque plate to a chassis of the appliance. A shoulder portion of the shoulder element is positioned to engage the engagement area of the anti-torque plate such that movement of the anti-torque plate in a plane that is parallel to the twisting motion is restrained by the shoulder portion engaging the engagement area, and movement of the anti-torque plate is permitted along a length of the shoulder portion.
摘要翻译: 提供了一种器具的管道和连接器组件。 组件具有用于连接到器具的流体系统的管道; 流体连接到管道的过渡部分; 连接器部分,用于通过在外部流体供应源和连接器部分之间的扭转运动连接到外部流体供应源; 所述防扭矩板刚性地固定到所述过渡部分,所述防扭矩板具有接合区域; 以及用于将抗扭矩板附接到器具的底盘的肩部元件。 肩部元件的肩部被定位成与抗扭矩板的接合区域接合,使得抗扭矩板在平行于扭转运动的平面中的运动被接合接合区域的肩部限制, 并且允许沿着肩部的长度的抗扭矩板的移动。
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公开(公告)号:US20110265908A1
公开(公告)日:2011-11-03
申请号:US13092762
申请日:2011-04-22
申请人: Claude Clerc , Alexander Turovsky , Michael E. Zupkofska , Christopher Dubois , Mark Wood , Gary Jordan
发明人: Claude Clerc , Alexander Turovsky , Michael E. Zupkofska , Christopher Dubois , Mark Wood , Gary Jordan
CPC分类号: A61F2/90 , A61F2230/0078 , A61F2240/001 , A61F2250/0039 , D04C1/06 , D04C3/48 , D04C7/00 , D10B2509/06 , Y10T29/49998
摘要: A mandrel for manufacturing a stent from a single wire includes a cylindrical member having a plurality of pins at a proximal end region, a plurality of pins at a distal end region, and a plurality of indentations between the proximal pins and the distal pins. These indentations form a helical pattern on the outer surface of the cylindrical member. The single wire is wrapped around every proximal pin and distal pin on the mandrel by following the indentations in the mandrel. The single wire is slid through the indentation under any crossing section of wire and over the next crossing section of wire in an under-over pattern.
摘要翻译: 用于从单线制造支架的心轴包括:在近端区域具有多个销的圆柱形构件,在远端区域处的多个销以及近端销和远端销之间的多个凹口。 这些凹陷在圆柱形构件的外表面上形成螺旋形图案。 通过跟随心轴中的凹陷将单根线缠绕在心轴上的每个近端销和远端销上。 单根导线在导线的任何交叉部分下滑过穿过凹陷,并且以下面的图案在导线的下一个交叉部分之上滑动。
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公开(公告)号:US20110112162A9
公开(公告)日:2011-05-12
申请号:US12577799
申请日:2009-10-13
申请人: Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova
发明人: Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Zenova
IPC分类号: A61K31/407 , C07D491/107 , C07D491/20 , A61P25/00 , A61P9/00 , A61P11/00
CPC分类号: C07D491/107 , C07D491/20
摘要: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译: 本发明涉及螺 - 羟吲哚化合物,作为立体异构体,对映体,其互变异构体或其混合物; 或其药学上可接受的盐,溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症,例如疼痛。
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