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    Maldi-matrix
    3.
    发明申请
    Maldi-matrix 审中-公开
    马尔迪矩阵

    公开(公告)号：US20050158863A1

    公开(公告)日：2005-07-21

    申请号：US10503935

    申请日：2003-07-30

    申请人： Bernd Stahl ,  Gunther Boehm ,  Marko Mank

    发明人： Bernd Stahl ,  Gunther Boehm ,  Marko Mank

    IPC分类号： G01N27/64 ,  G01N27/447 ,  G01N27/62 ,  G01N30/72 ,  G01N33/68 ,  H01J49/16 ,  G01N31/00

    CPC分类号： H01J49/164 ,  G01N33/6848 ,  G01N33/6851 ,  Y10T436/10

    摘要： Matrices for ultraviolet matrix-assisted laser desorption/ionisation mass spectrometry consisting of a salt of an amine reacting as a proton acceptor and an organic substance reacting as a proton donor, wherein either the amine or the organic substance absorbs UV light, are provided These matrices are characterised in that the matrices are in the form of an ionic liquid at room temperature, that the amine is selected from the group consisting of 3-aminoquinoline, pyridine, a primary amine, to whose N atom may be bound a phenyl residue or a linear or branched, saturated C1-C11 alkyl residue, which may be substituted with an OH group, a secondary and tertiary amine, to whose N atom may be bound two or three residues, which may be the same or different. With these liquid matrices, error-free and reproducible analytical values can be obtained, and in particular the coupling of the pure mass spectrometric analysis with the additional findings from enzymatic reactions/modifications with the possibility of monitoring is possible.

    摘要翻译： 提供由作为质子受体反应的胺的盐和作为质子供体反应的有机物质的紫外线矩阵辅助激光解吸/电离质谱的基质，其中胺或有机物质吸收紫外光。这些基质 其特征在于，所述基质在室温下为离子液体的形式，所述胺选自3-氨基喹啉，吡啶，伯胺，其N原子可与苯基残基或 直链或支链饱和C 1 -C 11烷基，其可以被OH基团，仲胺和叔胺取代，其N原子可以被结合两个 或三个残基，其可以相同或不同。 利用这些液体基质，可以获得无错误和可重现的分析值，特别是纯质谱分析与酶反应/修饰的附加结果与监测的可能性的耦合是可能的。