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    Method of enhancing immune response
    3.
    发明授权
    Method of enhancing immune response 失效
    增强免疫反应的方法

    公开(公告)号：US06805701B1

    公开(公告)日：2004-10-19

    申请号：US09362231

    申请日：1999-07-28

    申请人： Marta Cortes

    发明人： Marta Cortes

    IPC分类号： A61N500

    CPC分类号： A61N5/06 ,  A61N2005/067

    摘要： The present invention generally relates to a method for the site specific enhancement of cytokine release (through chemotaxis) namely beta chemokines and enhance healing via an enhanced overall immune response. The site specific enhancement of cytokine release is achieved by initiating an inflamatory response by laser therapy.

    摘要翻译： 本发明一般涉及通过增强的整体免疫应答增强细胞因子释放（通过趋化性）即β趋化因子并增强愈合的位点特异性增强的方法。 通过激光治疗引发炎症反应来实现细胞因子释放的位点特异性增强。

    LINGO binding molecules and pharmaceutical use thereof
    6.
    发明授权
    LINGO binding molecules and pharmaceutical use thereof 失效
    LINGO结合分子及其药物用途

    公开(公告)号：US08299221B2

    公开(公告)日：2012-10-30

    申请号：US12514542

    申请日：2007-11-15

    申请人： Adrian Walmsley ,  William Leonard Wishart ,  Marta Cortes-Cros ,  Josef Prassler ,  Ingo Klagge

    发明人： Adrian Walmsley ,  William Leonard Wishart ,  Marta Cortes-Cros ,  Josef Prassler ,  Ingo Klagge

    IPC分类号： A61K39/00

    CPC分类号： C07K16/28 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/30

    摘要： The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, and a polynucleotide encoding the binding molecule. The invention also provides an expression vector comprising the polynucleotide, an expression system comprising a polynucleotide capable of producing a binding molecule, as well as an isolated host cell comprising the expression system for producing the binding molecule. The invention also provides for compositions comprising the LINGO binding molecules and the use of binding molecule compositions as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity. The invention further provides for a method of treatment of diseases associated with axonal degeneration and demyelination.

    摘要翻译： 本发明提供能够结合大鼠，食蟹猴和人LINGO多肽的结合分子和编码结合分子的多核苷酸。 本发明还提供了包含多核苷酸的表达载体，包含能够产生结合分子的多核苷酸的表达系统，以及包含用于产生结合分子的表达系统的分离的宿主细胞。 本发明还提供包含LINGO结合分子的组合物和结合分子组合物作为药物的用途，特别是在促进轴突再生/可塑性的治疗中。 本发明还提供了治疗与轴索变性和脱髓鞘相关的疾病的方法。