公开(公告)号：US06480281B1

公开(公告)日：2002-11-12

申请号：US09527200

申请日：2000-03-16

申请人： Martinus B. Van Der Mark ,  Gert W. 'T Hooft

发明人： Martinus B. Van Der Mark ,  Gert W. 'T Hooft

IPC分类号： G01N2149

CPC分类号： A61B5/0091 ,  A61B5/4312

摘要： The invention relates to a device for localizing objects in turbid media. The device can be used for optical mammography. In optical mammography the interior of the part of the breast to be examined is imaged. The device includes a holder for receiving the part of the breast of a female. This holder is provided with light sources and photodetectors. The holder also contains a matching liquid in order to provide an optical coupling between the light sources and the part of the breast and as well as an optical coupling between the part of the breast and the photodetectors. In order to obtain such images, the part of the breast of a female to be examined is positioned in the holder and a resilient sealing ring is placed around the part of the breast and the upper side of the holder. The resilient sealing ring improves the filling of the holder with matching liquid, thus reducing imaging artefacts in the reconstructed images.

摘要翻译： 本发明涉及一种用于定位混浊介质中物体的装置。 该装置可用于光学乳腺摄影。 在光学乳腺摄影中，要检查的乳房部分的内部成像。 该装置包括用于接收女性的乳房的一部分的保持器。 该支架配有光源和光电检测器。 保持器还包含匹配液体，以便在光源和乳房的一部分之间提供光耦合，以及乳房部分和光电探测器之间的光耦合。 为了获得这样的图像，要检查的女性的乳房的一部分位于保持器中，并且弹性密封环被放置在乳房的一部分和保持器的上侧周围。 弹性密封环改善了保持器与匹配液体的填充，从而减少了重建图像中的成像伪影。

公开(公告)号：US06327488B1

公开(公告)日：2001-12-04

申请号：US09073508

申请日：1998-05-06

申请人： Martinus B. Van Der Mark ,  Nicolaas A. A. J. Van Asten ,  Wilhelmus M. Walraven

发明人： Martinus B. Van Der Mark ,  Nicolaas A. A. J. Van Asten ,  Wilhelmus M. Walraven

IPC分类号： A61B500

CPC分类号： A61B5/0091 ,  A61B5/4312 ,  G02B6/262

摘要： The light to be generated by a light source in a device for localizing an object in a turbid medium is successively coupled into the turbid medium from different directions by use of an optical detection unit. The light coupled in is transported in different directions through the turbid medium. A part of the light emanating from the turbid medium is measured by use of photodetectors. An image of the interior of the turbid medium is reconstructed by optical tomography on the basis of the measured intensities. The device includes structure which reduces variations in the intensity of the light coupled into the turbid medium from the same direction in order to reduce errors occurring on repeated executions of the measurements for successively localizing the object.

摘要翻译： 在用于使浑浊介质中的物体定位的装置中由光源产生的光通过使用光学检测单元从不同方向连续地耦合到混浊介质中。 耦合的光通过混浊介质在不同方向运输。 通过使用光电检测器测量从混浊介质发出的光的一部分。 基于测量的强度，通过光学层析成像重建混浊介质内部的图像。 该装置包括从相同方向减少耦合到混浊介质中的光的强度的变化的结构，以便减少在重复执行用于连续定位物体的测量时发生的误差。

公开(公告)号：US5907406A

公开(公告)日：1999-05-25

申请号：US909917

申请日：1997-08-12

申请人： Dimitrios Papaioannou ,  Gert W. t Hooft ,  Martinus B. Van Der Mark ,  Sel B. Colak

发明人： Dimitrios Papaioannou ,  Gert W. t Hooft ,  Martinus B. Van Der Mark ,  Sel B. Colak

IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B10/00 ,  G01N21/47 ,  G01N21/49 ,  G01B21/00

CPC分类号： A61B5/0091 ,  A61B5/4312 ,  G01N21/4795

摘要： A device for imaging a turbid medium, for example a breast of a female, includes a holder for receiving the turbid medium, a light source, a photodetector and a processing unit for deriving the image from the intensities measured. The holder is adapted to receive besides the turbid medium also an adaptation medium having substantial identical optical parameters as the optical parameters of the turbid medium. In this way artefacts in the reconstructed image due to the boundary effect between the turbid medium and the holder can be reduced. When a liquid is used as the adaptation medium a perfect match between the holder and the shape of the turbid medium can be obtained. Further, also intensity differences in the image due to different path lengths between light source and photodetector can be equalized.

摘要翻译： 用于对浑浊介质（例如女性的乳房）进行成像的装置包括用于接收浑浊介质的保持器，光源，光电检测器和用于从测量的强度导出图像的处理单元。 保持器适于接收混浊介质以外还具有与混浊介质的光学参数基本上相同的光学参数的适配介质。 以这种方式，可以减少由于混浊介质和保持器之间的边界效应引起的重建图像中的伪像。 当使用液体作为适应介质时，可以获得保持器与混浊介质的形状之间的完美匹配。 此外，由于光源和光电检测器之间的不同路径长度的图像中的强度差也可以相等。

公开(公告)号：US5955837A

公开(公告)日：1999-09-21

申请号：US948473

申请日：1997-10-10

申请人： Jeroen J. L. Horikx ,  Coen T. H. F. Liedenbaum ,  Martinus B. van der Mark ,  Adrianus J. M. Berntsen ,  Jeroen J. M. Vleggaar ,  Henri M. J. Boots

发明人： Jeroen J. L. Horikx ,  Coen T. H. F. Liedenbaum ,  Martinus B. van der Mark ,  Adrianus J. M. Berntsen ,  Jeroen J. M. Vleggaar ,  Henri M. J. Boots

IPC分类号： G02B6/00 ,  G02B5/02 ,  G02F1/1335 ,  G02F1/13357 ,  H01L33/00 ,  H01L51/52 ,  H05B33/12 ,  H05B33/22 ,  H01J1/62

CPC分类号： H01L51/5268 ,  H05B33/22

摘要： The illumination system (1) has a substrate (2) and an active layer (3) comprising an electroluminescent material, in which the active layer (3) is present between a first, optically transparent electrode layer (5) and a second electrode layer (7). The illumination system (1) is characterized in that a light-scattering layer (28) comprising a medium having light-scattering properties is present in a forward direction (29) with respect to the active layer (3), in which the non-scattered fraction of a (collimated) light beam, when passed through the light-scattering layer (8) in the forward direction (29), is in the range between 0.05 and 0.8, preferably in the range between 0.1 and 0.5. The light-scattering properties of the medium are preferably stronger as the light is more obliquely incident, as is achieved by using birefringent particles and/or media. A very suitable light-scattering layer (28) is a (half) monolayer of TiO.sub.2 particles provided on the substrate (2), with an average size of the (spherical) particles of 0.1-1 .mu.m. The light output of the illumination system (1) is further improved by providing the edges of the substrate (2) with a reflective coating (26).

摘要翻译： 照明系统（1）具有基板（2）和包括电致发光材料的有源层（3），其中有源层（3）存在于第一光学透明电极层（5）和第二电极层 （7）。 照明系统（1）的特征在于，包括具有光散射特性的介质的光散射层（28）相对于有源层（3）在正向（29）上存在，其中， （准直）光束的散射分数在向前（29）方向通过光散射层（8）时的分布在0.05和0.8之间，优选在0.1和0.5之间的范围内。 如通过使用双折射颗粒和/或介质所达到的那样，介质的光散射性质优选随着光线更倾斜入射而变强。 非常合适的光散射层（28）是设置在基板（2）上的（半）单层TiO 2颗粒，其中（球形）颗粒的平均尺寸为0.1-1μm。 通过使基板（2）的边缘设置有反射涂层（26），进一步改善照明系统（1）的光输出。