公开(公告)号：US20050124831A1

公开(公告)日：2005-06-09

申请号：US10507027

申请日：2003-03-07

Applicant: Shu Kobayashi ,  Masaharu Sugiura

Inventor： Shu Kobayashi ,  Masaharu Sugiura

IPC: C07D263/22 ,  B01J27/13 ,  B01J31/30 ,  C07B61/00 ,  C07C269/06 ,  C07C271/18 ,  C07C271/24 ,  C07C29/30

CPC classification number: C07C269/06 ,  B01J27/13 ,  B01J31/30 ,  C07C271/18 ,  C07C271/24

Abstract: A conjugate addition reaction between an α,β-unsaturated ketone compound and a carbamate compound is carried out to synthesize a β-aminoketone, a salt or a hydrate salt of a transition metal of Groups 7 to 11 of the Periodic Table of Elements being present in the reaction system as the catalyst. The novel method and the catalyst are capable of synthesizing the β-aminoketone by the Aza-Michael reaction with high yield and efficiency.

Abstract translation: 进行α，β-不饱和酮化合物和氨基甲酸酯化合物之间的共轭加成反应，以合成出现的元素周期表第7〜11族的过渡金属的β-氨基酮，盐或水合物盐 在反应体系中作为催化剂。 新方法和催化剂能够以高产率和高效率通过Aza-Michael反应合成β-氨基酮。

公开(公告)号：US07246694B2

公开(公告)日：2007-07-24

申请号：US10559822

申请日：2004-07-16

Applicant: Yasushi Yamahara ,  Masanori Motoda ,  Masashi Kimura ,  Masaharu Sugiura ,  Akira Ishii ,  Toshitaka Aoki

Inventor： Yasushi Yamahara ,  Masanori Motoda ,  Masashi Kimura ,  Masaharu Sugiura ,  Akira Ishii ,  Toshitaka Aoki

IPC: B65G39/02

CPC classification number: B65G39/02 ,  B65G2201/0267 ,  Y10T152/10405

Abstract: A friction roller (10) includes a support roller (11) and an annular elastic ring (15) which it externally fitted to the support roller (11). The support roller (11) is divided into two portions in a thickness direction, that is, a first divided roller (12) and a second divided roller (13). A flange (127) is formed on one side of the first divided roller (12), and a taper face (128) is formed in an outer peripheral face of the first divided roller (12). A knurling portion (129) is formed in the taper face (128). A flange (136) is formed on one side of the second divided roller (13), and a taper face (137) is formed in an outer peripheral face of the second divided roller (13). A knurling portion (138) is formed in the taper face (137). Meanwhile, taper faces (151, 152) expanding outward are formed in an inner peripheral face of the elastic ring (15). The taper faces (151, 152) of the elastic ring (15) are engaged with the taper face (128) of the first divided roller (12) and the taper face (137) of the second divided roller (13).

Abstract translation: 摩擦辊（10）包括支撑辊（11）和外部装配到支撑辊（11）的环形弹性环（15）。 支撑辊（11）沿厚度方向分为两部分，即第一分割辊（12）和第二分割辊（13）。 在第一分割辊（12）的一侧形成有凸缘（127），在第一分割辊（12）的外周面形成有锥面（128）。 在锥面（128）中形成有滚花部（129）。 在第二分割辊（13）的一侧形成有凸缘（136），在第二分割辊（13）的外周面形成有锥面（137）。 在锥面（137）中形成有滚花部（138）。 同时，在弹性环（15）的内周面形成有向外侧扩大的锥面（151,152）。 弹性环（15）的锥面（151,152）与第一分割辊（12）的锥面（128）和第二分割辊（13）的锥面（137）接合。

公开(公告)号：US07659424B2

公开(公告)日：2010-02-09

申请号：US10591094

申请日：2005-02-24

Applicant: Shu Kobayashi ,  Masaharu Sugiura

Inventor： Shu Kobayashi ,  Masaharu Sugiura

IPC: C07C241/02 ,  C07C227/04 ,  C07C229/08 ,  C07C243/38

CPC classification number: C07C241/02 ,  C07B53/00 ,  C07C2601/14 ,  C07C243/38

Abstract: [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained.[MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]: [wherein R0 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or —COOR1 (wherein R1 is a hydrocarbon group); R2 is acyl; R3 and R4 are each hydrogen, or one of R3 and R4 is hydrogen and the other is a hydrocarbon group; and R5 and R6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]: [wherein R0 and R2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.

Abstract translation: [问题]提供N-酰腙的烯丙基化的新方法，通过该方法可以有效地获得对映选择性烯丙化的N-酰肼。 用于解决问题的方法制备由通式[3]表示的对映选择性烯丙化N-酰肼的方法：[其中R 0是任选取代的烃基，任选取代的杂环基或-COOR 1（其中R 1是 烃基）; R2是酰基; R3和R4各自为氢，R3和R4中的一个为氢，另一个为烃基; R 5和R 6各自独立地为氢或烃基]，其特征在于使由通式[1]表示的N-酰腙：[其中R 0和R 2如上定义]与烯丙基化试剂如烯丙基三氯硅烷或基环丙基三氯硅烷反应 存在手性氧化膦。

公开(公告)号：US20060151080A1

公开(公告)日：2006-07-13

申请号：US10559822

申请日：2004-07-16

Applicant: Yasushi Yamahara ,  Masanori Motoda ,  Masashi Kimura ,  Masaharu Sugiura ,  Akira Ishii ,  Toshitaka Aoki

Inventor： Yasushi Yamahara ,  Masanori Motoda ,  Masashi Kimura ,  Masaharu Sugiura ,  Akira Ishii ,  Toshitaka Aoki

IPC: B65G39/02

CPC classification number: B65G39/02 ,  B65G2201/0267 ,  Y10T152/10405

Abstract: A friction roller (10) includes a support roller (11) and an annular elastic ring (15) which it externally fitted to the support roller (11). The support roller (11) is divided into two portions in a thickness direction, that is, a first divided roller (12) and a second divided roller (13). A flange (127) is formed on one side of the first divided roller (12), and a taper face (128) is formed in an outer peripheral face of the first divided roller (12). A knurling portion (129) is formed in the taper face (128). A flange (136) is formed on one side of the second divided roller (13), and a taper face (137) is formed in an outer peripheral face of the second divided roller (13). A knurling portion (138) is formed in the taper face (137). Meanwhile, taper faces (151, 152) expanding outward are formed in an inner peripheral face of the elastic ring (15). The taper faces (151, 152) of the elastic ring (15) are engaged with the taper face (128) of the first divided roller (12) and the taper face (137) of the second divided roller (13).

Abstract translation: 摩擦辊（10）包括支撑辊（11）和外部装配到支撑辊（11）的环形弹性环（15）。 支撑辊（11）沿厚度方向分为两部分，即第一分割辊（12）和第二分割辊（13）。 在第一分割辊（12）的一侧形成有凸缘（127），在第一分割辊（12）的外周面形成有锥面（128）。 在锥面（128）中形成有滚花部（129）。 在第二分割辊（13）的一侧形成有凸缘（136），在第二分割辊（13）的外周面形成有锥面（137）。 在锥面（137）中形成有滚花部（138）。 同时，在弹性环（15）的内周面形成有向外侧扩大的锥面（151,152）。 弹性环（15）的锥面（151,152）与第一分割辊（12）的锥面（128）和第二分割辊（13）的锥面（137）接合。

公开(公告)号：US07164043B2

公开(公告)日：2007-01-16

申请号：US10507027

申请日：2003-03-07

Applicant: Shu Kobayashi ,  Masaharu Sugiura

Inventor： Shu Kobayashi ,  Masaharu Sugiura

IPC: C07C209/60

CPC classification number: C07C269/06 ,  B01J27/13 ,  B01J31/30 ,  C07C271/18 ,  C07C271/24

Abstract: A conjugate addition reaction between an α,β-unsaturated ketone compound and a carbamate compound is carried out to synthesize a β-aminoketone, a salt or a hydrate salt of a transition metal of Groups 7 to 11 of the Periodic Table of Elements being present in the reaction system as the catalyst. The novel method and the catalyst are capable of synthesizing the β-aminoketone by the Aza-Michael reaction with high yield and efficiency.

Abstract translation: 进行α，β-不饱和酮化合物和氨基甲酸酯化合物之间的共轭加成反应，以合成出现的元素周期表第7〜11族的过渡金属的β-氨基酮，盐或水合物盐 在反应体系中作为催化剂。 新方法和催化剂能够以高产率和高效率通过Aza-Michael反应合成β-氨基酮。

公开(公告)号：US20070142672A1

公开(公告)日：2007-06-21

申请号：US10591094

申请日：2005-02-24

Applicant: Shu Kobayashi ,  Masaharu Sugiura

Inventor： Shu Kobayashi ,  Masaharu Sugiura

IPC: C07C243/10

CPC classification number: C07C241/02 ,  C07B53/00 ,  C07C2601/14 ,  C07C243/38

Abstract: [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained. [MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]: [wherein R0 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or —COOR1 (wherein R1 is a hydrocarbon group); R2 is acyl; R3 and R4 are each hydrogen, or one of R3 and R4 is hydrogen and the other is a hydrocarbon group; and R5 and R6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]: [wherein R0 and R2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.

Abstract translation: [问题]提供N-酰腙的烯丙基化的新方法，通过该方法可以有效地获得对映选择性烯丙化的N-酰肼。 用于解决问题的方法制备由通式[3]表示的对映选择性烯丙化N-酰肼的方法：其中R 0为任选取代的烃基，任选取代的杂环基， 或-COOR 1（其中R 1为烃基）; R 2是酰基; R 3和R 4各自为氢，R 3和R 4中的一个为氢，另一个为氢 是一个烃基; 和R 5和R 6各自独立地为氢或烃基]，其特征在于使由通式[1]表示的N-酰腙：[其中R' 在含有手性氧化膦的存在下，与烯丙基化试剂如烯丙基三氯硅烷或巴豆基三氯硅烷进行反应来制备。