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    Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore
    4.
    发明授权
    Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore 有权
    因此制造光学活性羟甲基化化合物和催化剂的方法

    公开(公告)号：US07541307B2

    公开(公告)日：2009-06-02

    申请号：US11795525

    申请日：2006-01-27

    申请人： Shu Kobayashi ,  Kei Manabe

    发明人： Shu Kobayashi ,  Kei Manabe

    IPC分类号： B01J31/00 ,  C07C45/00 ,  C07C49/00

    CPC分类号： B01J31/2213 ,  B01J31/1815 ,  B01J2231/321 ,  B01J2531/0252 ,  B01J2531/54 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/511 ,  C07C49/497 ,  C07C49/747 ,  C07C49/82 ,  C07C49/84

    摘要： A silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3.

    摘要翻译： 由下式（式1）表示的硅烯醇化物（式中，R5〜R7表示氢原子，脂肪族烃基，单环或多环脂肪族烃基，单环或多环芳香族或芳香族 - 脂肪族烃基或杂环基，R5 和R 7不同，R 6不是氢原子，各R 8可以相同或不同，表示甲基，乙基或异丙基）和甲醛在水和有机溶剂的混合溶剂中反应 在通过混合包含手性联吡啶化合物或其对映体的配体和Bi（OTf）3）获得的催化剂存在下进行。

    Production method for aminophosphonic acid derivatives
    6.
    发明授权
    Production method for aminophosphonic acid derivatives 有权
    氨基膦酸衍生物的制备方法

    公开(公告)号：US07375244B2

    公开(公告)日：2008-05-20

    申请号：US10591964

    申请日：2005-03-07

    申请人： Shu Kobayashi

    发明人： Shu Kobayashi

    IPC分类号： C07F9/02

    CPC分类号： B01J31/1805 ,  B01J2531/16 ,  C07B53/00 ,  C07F9/3808 ,  C07F9/3882 ,  C07F9/4006 ,  C07F9/4056

    摘要： To present a reaction system that efficiently catalyzes an enantio selective asymmetric nucleophilic addition reaction of an α-iminophosphonic acid ester. An optically active α-amino-γ-oxophosphonic acid derivative is produced through an asymmetric addition reaction of an α-iminophosphonic acid ester and a nucleophilic agent (for example, a silyl enol ether).

    摘要翻译： 提出有效催化α-亚氨基膦酸酯的对映选择性不对称亲核加成反应的反应体系。 通过α-亚氨基膦酸酯和亲核剂（例如甲硅烷基烯醇醚）的不对称加成反应产生光学活性的α-氨基-γ-氧代膦酸衍生物。

    Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of a-amino-y-keto acid ester
    7.
    发明申请
    Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of a-amino-y-keto acid ester 失效
    酰胺对亚胺的对映选择性亲核加成反应方法及α-氨基-γ-酮酸酯的合成方法

    公开(公告)号：US20070161804A1

    公开(公告)日：2007-07-12

    申请号：US10587075

    申请日：2004-01-25

    申请人： Shu Kobayashi

    发明人： Shu Kobayashi

    IPC分类号： C07D207/14

    CPC分类号： C07B53/00 ,  B01J31/1805 ,  B01J2231/341 ,  B01J2531/16 ,  C07B2200/07 ,  C07C231/18 ,  C07D207/273

    摘要： An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthio-selective nucleophilic addition reaction to imine compound being a method of nucleophilic addition reaction of enamide compound accompanied by amino formation to imino group (—CH═N—) of imine compound, characterized in that the reaction is performed in the presence of a chiral copper catalyst. Further, there is provided a novel method of synthesizing an amino acid compound, etc., to which the above is applied.

    摘要翻译： 可用作药物，农药，香料，功能性聚合物等的原料或合成中间体的氨基酸化合物的不对称合成。提供了一种亚胺化合物的富含选择性亲核加成反应的方法， 伴随氨基形成的酰胺化合物与亚胺基（-CH-N-）亚胺化合物的亲核加成反应，其特征在于反应在手性铜催化剂存在下进行。 此外，提供了一种合成上述应用的氨基酸化合物等的新方法。

    Method of enantioselective nucleophilic addition reaction of enamide to carbonyl group and synthesis method of optically active alpha-hydroxy-y-keto acid ester and hydroxydiketone
    8.
    发明申请
    Method of enantioselective nucleophilic addition reaction of enamide to carbonyl group and synthesis method of optically active alpha-hydroxy-y-keto acid ester and hydroxydiketone 有权
    酰胺对羰基的对映选择性亲核加成反应的方法和光学活性α-羟基 - 酮酸酯和羟基二酮的合成方法

    公开(公告)号：US20070073087A1

    公开(公告)日：2007-03-29

    申请号：US10587078

    申请日：2005-01-24

    申请人： Shu Kobayashi

    发明人： Shu Kobayashi

    IPC分类号： C07C49/00

    CPC分类号： C07D207/18 ,  C07B2200/07 ,  C07C67/343 ,  C07C269/04 ,  C07C69/738 ,  C07C69/716

    摘要： A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active α-hydroxy-γ-keto acid ester, an optically active α-hydroxy-γ-amino acid ester, hydroxydiketone compounds, etc. being useful as a raw material or synthesis intermediate for producing a pharmaceutical preparation, an agricultural chemical, a fragrance, a functional polymer or the like. In this method, the nucleophilic addition reaction of enamide compound accompanied by hydroxyl (—OH) formation to carbonyl is carried out in the presence of a chiral catalyst with copper or nickel.

    摘要翻译： 对羰基的对映选择性亲核加成反应的方法，其使得光学活性α-羟基-γ-酮酸酯，光学活性α-羟基-γ-氨基酸酯，羟基二酮化合物等的不对称合成是有用的 作为制备药物制剂，农药，香料，功能聚合物等的原料或合成中间体。 在这种方法中，伴随着羟基（-OH）形成羰基的烯酰胺化合物的亲核加成反应在具有铜或镍的手性催化剂的存在下进行。

    Polymer-immobilized formamides, catalyst containing the same and allylation process
    9.
    发明申请
    Polymer-immobilized formamides, catalyst containing the same and allylation process 审中-公开
    聚合物固定化甲酰胺，含有相同的催化剂和烯丙基化方法

    公开(公告)号：US20060111590A1

    公开(公告)日：2006-05-25

    申请号：US10539615

    申请日：2003-12-17

    申请人： Shu Kobayashi

    发明人： Shu Kobayashi

    IPC分类号： C08F8/30 ,  C07C241/02 ,  C08C19/22 ,  C07C27/18

    CPC分类号： C08F8/30 ,  B01J31/0237 ,  B01J31/0247 ,  B01J31/06 ,  B01J31/4007 ,  B01J2231/341 ,  C07C29/38 ,  C07C243/38 ,  C07C2601/16 ,  Y02P20/584 ,  C07C33/20

    摘要： Polymer-immobilized form amides characterized by being represented by the general formula: (wherein R1 is an optionally substituted hydrocarbon chain which may have a cyclic moiety or a heteroatom; R2 is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon chain which is bonded to R1 to form a ring; and the solid circle represents a polymer); novel organic catalysts containing the same, which catalysts are free from metallic catalyst components and very easy of recovery from reaction mixtures of synthesis and reuse; polymer-immobilized organic compounds useful as intermediates for synthesis; catalysts containing the same as the active ingredient; and a process for the allylation of aldehydes or hydrazones by the use of these catalysts.

    摘要翻译： 聚合物固定形式的酰胺，其特征在于由以下通式表示：（其中R 1是可以具有环状部分或杂原子的任选取代的烃链; R 2， 是任选取代的烃基或任选取代的烃链，其与R 1键合以形成环;并且实心圆代表聚合物）; 含有该催化剂的新型有机催化剂，其不含金属催化剂组分，并且非常容易从合成和再利用的反应混合物中回收; 可用作合成中间体的聚合物固定化有机化合物; 含有与活性成分相同的催化剂; 以及通过使用这些催化剂使醛或腙烯丙基化的方法。