公开(公告)号：US20120208813A1

公开(公告)日：2012-08-16

申请号：US13407520

申请日：2012-02-28

申请人： Natsuki ISHIZUKA ,  Takashi SASATANI ,  Yoshiharu HIRAMATSU ,  Masanao INAGAKI ,  Masahide ODAN ,  Hiroshi HASHIZUMI ,  Susumu MITSUMORI ,  Yasuhiko FUJII ,  Yoshikazu FUKUI ,  Hideaki WATANABE ,  Jun SATO

发明人： Natsuki ISHIZUKA ,  Takashi SASATANI ,  Yoshiharu HIRAMATSU ,  Masanao INAGAKI ,  Masahide ODAN ,  Hiroshi HASHIZUMI ,  Susumu MITSUMORI ,  Yasuhiko FUJII ,  Yoshikazu FUKUI ,  Hideaki WATANABE ,  Jun SATO

IPC分类号： A61K31/435 ,  C07D495/04 ,  A61K31/4365 ,  A61P17/00 ,  A61K31/496 ,  A61K31/506 ,  C07D413/12 ,  A61K31/5377 ,  C07D221/04 ,  C07D401/12

CPC分类号： C07D213/82

摘要： The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1, R2, R3, R4, and G are defined as herein, a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

摘要翻译： 本发明提供对大麻素受体具有激动作用的化合物，其由式（I）表示：其中R 1，R 2，R 3，R 4和G如本文所定义，其药学上可接受的盐或溶剂合物，以及 药物组合物，特应性皮炎治疗剂和抗瘙痒剂，特别是用于口服和外用的抗瘙痒剂，其各自含有所述化合物作为活性成分。

公开(公告)号：US20080103139A1

公开(公告)日：2008-05-01

申请号：US11628804

申请日：2005-10-28

申请人： Natsuki Ishizuka ,  Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Masanao Inagaki ,  Masahide Odan ,  Hiroshi Hashizume ,  Susumu Mitsumori ,  Yasuhiko Fujii ,  Yoshikazu Fukui ,  Hideaki Watanabe ,  Jun Sato

发明人： Natsuki Ishizuka ,  Takashi Sasatani ,  Yoshiharu Hiramatsu ,  Masanao Inagaki ,  Masahide Odan ,  Hiroshi Hashizume ,  Susumu Mitsumori ,  Yasuhiko Fujii ,  Yoshikazu Fukui ,  Hideaki Watanabe ,  Jun Sato

IPC分类号： A61K31/5377 ,  C07D221/04 ,  A61K31/435 ,  C07D211/84 ,  A61K31/4412 ,  A61P17/00 ,  C07D401/12 ,  A61K31/496 ,  A61K31/506 ,  C07D413/12

CPC分类号： C07D213/82

摘要： The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1 is optionally substituted C1-C8 alkyl and the like; R2 is C1-C6 alkyl; R3 is C1-C6 alkyl and the like; or R2 and R3 taken together with may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R4 is hydrogen and the like; G is a group selected from the groups shown by the formula an the like: wherein R5 is hydrogen and the like; X1 is a single bond and the like; X2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of —O—, or —N(R6)—, wherein R6 is hydrogen and the like, and the like; X3 is a single bond and the like; a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

摘要翻译： 本发明提供对大麻素受体具有激动作用的化合物，其由式（I）表示：其中R 1是任选取代的C 1 -C 8烷基等; R 2是C 1 -C 6烷基; R 3是C 1 -C 6烷基等; 或R 2和R 3与相邻碳原子一起可以形成任选取代的5至10元非芳族碳环; R 4是氢等; G为选自下式的基团：其中R 5为氢等; X 1是单键等; X 2是任选取代的C 1 -C 8亚烷基，其可以被一个或两个-O-或-N（R 6） - 基团取代，其中R 0 > 6是氢等; X 3是单键等; 其药学上可接受的盐或溶剂合物，以及药物组合物，特应性皮炎治疗剂和抗瘙痒剂，特别是用于口服和外用的抗瘙痒剂，其各自含有所述化合物作为活性成分。