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    COMPOUND HAVING TUMOR-RESIDENT PROPERTY
    1.
    发明申请
    COMPOUND HAVING TUMOR-RESIDENT PROPERTY 审中-公开
    具有肿瘤活性物质的化合物

    公开(公告)号：US20100202971A1

    公开(公告)日：2010-08-12

    申请号：US12688153

    申请日：2010-01-15

    申请人： Keisuke OHTA ,  Masahiko Miura ,  Kengo Sakaguchi ,  Fumio Sugawara ,  Masahiro Ishima ,  Hiroshi Murata

    发明人： Keisuke OHTA ,  Masahiko Miura ,  Kengo Sakaguchi ,  Fumio Sugawara ,  Masahiro Ishima ,  Hiroshi Murata

    IPC分类号： A61K49/00 ,  C07D315/00 ,  A61K31/70

    CPC分类号： C07H15/10 ,  A61K47/551 ,  C07H15/04 ,  C07H15/06 ,  C07H15/08 ,  C07H15/18

    摘要： The problem to be solved of the present invention is to provide a novel compound which specifically resides in a tumor, a method for allowing it to reside in a tumor, and a method for detecting, diagnosing, and treating tumor with use thereof. Means for solving the problem is a compound represented by chemical formula (I) wherein R is an anionic group binding to hydrogen, R1 is OH, OCOH, OCO(CH2)hCH3, or an acting group, h being an integer of 0 or more, R2 is H, OH, OCOH, OCO(CH2)iCH3, or an acting group, i being an integer of 0 or more, R3 is OH, SO3H, or an acting group, R4 is OH, SO3H, or an acting group, and R5 is OH, SO3H, or an acting group, at least one of R1, R2, R3, R4, and R5 containing an acting group, or pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明要解决的问题是提供一种特异性存在于肿瘤中的新型化合物，使其能够存在于肿瘤中的方法，以及使用该方法检测，诊断和治疗肿瘤的方法。 用于解决问题的方法是由化学式（I）表示的化合物，其中R是与氢结合的阴离子基团，R 1是OH，OCOH，OCO（CH 2）h CH 3或作用基团，h是0或更大的整数 ，R2为H，OH，OCOH，OCO（CH2）iCH3或作用基，i为0以上的整数，R3为OH，SO3H或作用基，R4为OH，SO3H或作用基团 R5为OH，SO3H或作用基团，含有作用基团的R1，R2，R3，R4和R5中的至少一个或其药学上可接受的盐。

    Peptides, derivates thereof, process for producing the same, novel strain producing the same, and antiviral agent comprising the same as active ingredient
    2.
    发明授权
    Peptides, derivates thereof, process for producing the same, novel strain producing the same, and antiviral agent comprising the same as active ingredient 失效
    肽，其衍生物，其制备方法，产生其的新菌株，以及包含其作为活性成分的抗病毒剂

    公开(公告)号：US07268209B2

    公开(公告)日：2007-09-11

    申请号：US10632949

    申请日：2003-07-31

    申请人： Masahiro Ishima ,  Tsutomu Yoshida ,  Takayuki Yamazaki ,  Fumio Sugawara ,  Kiyoshige Hatta ,  Manabu Shimojoe ,  Kazuyoshi Masaki

    发明人： Masahiro Ishima ,  Tsutomu Yoshida ,  Takayuki Yamazaki ,  Fumio Sugawara ,  Kiyoshige Hatta ,  Manabu Shimojoe ,  Kazuyoshi Masaki

    IPC分类号： C07K5/00

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K11/00 ,  C07K14/21 ,  C12R1/38

    摘要： Peptides having, as constitutive amino acids, (1) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; (2) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 3 valine residues, and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; or (3) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydodec-5-enoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof. The peptides have an antiviral activity. A strain capable of producing the above peptides and belonging to a new species of genus Pseudomonas.

    摘要翻译： 作为组成型氨基酸的肽，具有（1）4个谷氨酰胺残基，1个谷氨酸残基，1个丝氨酸残基，2个缬氨酸残基，1个异亮氨酸残基和5个亮氨酸残基，并且具有通过酰胺键键合的3-羟基癸酰基， 至其N-末端亮氨酸残基; （2）4个谷氨酰胺残基，1个谷氨酸残基，1个丝氨酸残基，3个缬氨酸残基和5个亮氨酸残基，并且具有通过酰胺键与其N-末端亮氨酸残基键合的3-羟基癸酰基; 或（3）4个谷氨酰胺残基，1个谷氨酸残基，1个丝氨酸残基，2个缬氨酸残基，1个异亮氨酸残基和5个亮氨酸残基，并且具有通过酰胺键与N键合的3-羟基二烯-5-烯酰基 - 其末端亮氨酸残基。 肽具有抗病毒活性。 能够产生上述肽并属于新型假单胞菌属的菌株。