Peptides, derivates thereof, process for producing the same, novel strain producing the same, and antiviral agent comprising the same as active ingredient
    1.
    发明授权
    Peptides, derivates thereof, process for producing the same, novel strain producing the same, and antiviral agent comprising the same as active ingredient 失效
    肽,其衍生物,其制备方法,产生其的新菌株,以及包含其作为活性成分的抗病毒剂

    公开(公告)号:US07268209B2

    公开(公告)日:2007-09-11

    申请号:US10632949

    申请日:2003-07-31

    IPC分类号: C07K5/00

    摘要: Peptides having, as constitutive amino acids, (1) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; (2) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 3 valine residues, and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; or (3) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydodec-5-enoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof. The peptides have an antiviral activity. A strain capable of producing the above peptides and belonging to a new species of genus Pseudomonas.

    摘要翻译: 作为组成型氨基酸的肽,具有(1)4个谷氨酰胺残基,1个谷氨酸残基,1个丝氨酸残基,2个缬氨酸残基,1个异亮氨酸残基和5个亮氨酸残基,并且具有通过酰胺键键合的3-羟基癸酰基, 至其N-末端亮氨酸残基; (2)4个谷氨酰胺残基,1个谷氨酸残基,1个丝氨酸残基,3个缬氨酸残基和5个亮氨酸残基,并且具有通过酰胺键与其N-末端亮氨酸残基键合的3-羟基癸酰基; 或(3)4个谷氨酰胺残基,1个谷氨酸残基,1个丝氨酸残基,2个缬氨酸残基,1个异亮氨酸残基和5个亮氨酸残基,并且具有通过酰胺键与N键合的3-羟基二烯-5-烯酰基 - 其末端亮氨酸残基。 肽具有抗病毒活性。 能够产生上述肽并属于新型假单胞菌属的菌株。