公开(公告)号：US07498145B2

公开(公告)日：2009-03-03

申请号：US11363094

申请日：2006-02-28

申请人： Kenichi Uchiyama ,  Kayoko Oomiya ,  Isao Kishimoto ,  Masami Hirata ,  Hideo Eto ,  Ichiro Tono ,  Ikuo Uematsu ,  Shingo Kasai ,  Tomohiro Takase ,  Tsutomu Honjoh ,  Masanori Sugitani

发明人： Kenichi Uchiyama ,  Kayoko Oomiya ,  Isao Kishimoto ,  Masami Hirata ,  Hideo Eto ,  Ichiro Tono ,  Ikuo Uematsu ,  Shingo Kasai ,  Tomohiro Takase ,  Tsutomu Honjoh ,  Masanori Sugitani

IPC分类号： G01N33/53 ,  G01N33/551 ,  G01N33/552 ,  G01N33/58

CPC分类号： G01N33/54373 ,  Y10S435/808 ,  Y10S436/805

摘要： The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the antibody immobilized layer of the sensor chip having an immobilized antibody, producing a color-developing and precipitating enzyme reaction product by allowing to react a coloring reagent with the labeling enzyme on the antibody immobilized layer to precipitate the enzyme reaction product on the antibody immobilized layer, allowing to totally reflect a light impinged on the sensor chip from the outside at an interface between the optical waveguide layer and the antibody immobilized layer, and observing to a physical value of the totally reflected light.

摘要翻译： 用于测量对象浓度的方法使用包括形成在光波导层表面上的光波导层和抗体固定层的传感器芯片，其包括固定测量对象和用​​标记的酶标记的抗体 酶在具有固定化抗体的传感器芯片的抗体固定化层上，通过使着色试剂与抗体固定化层上的标记酶反应，使酶反应产物沉淀在抗体上，产生显色和沉淀酶反应产物 使得能够在光波导层和抗体固定化层之间的界面处从外部全面反射入射到传感器芯片上的光，并观察全反射光的物理值。

公开(公告)号：US20060194345A1

公开(公告)日：2006-08-31

申请号：US11363094

申请日：2006-02-28

申请人： Kenichi Uchiyama ,  Kayoko Oomiya ,  Isao Kishimoto ,  Masami Hirata ,  Hideo Eto ,  Ichiro Tono ,  Ikuo Uematsu ,  Shingo Kasai ,  Tomohiro Takase ,  Tsutomu Honjoh ,  Masanori Sugitani

发明人： Kenichi Uchiyama ,  Kayoko Oomiya ,  Isao Kishimoto ,  Masami Hirata ,  Hideo Eto ,  Ichiro Tono ,  Ikuo Uematsu ,  Shingo Kasai ,  Tomohiro Takase ,  Tsutomu Honjoh ,  Masanori Sugitani

IPC分类号： G01N33/543 ,  C12M1/34

CPC分类号： G01N33/54373 ,  Y10S435/808 ,  Y10S436/805

摘要： The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the antibody immobilized layer of the sensor chip having an immobilized antibody, producing a color-developing and precipitating enzyme reaction product by allowing to react a coloring reagent with the labeling enzyme on the antibody immobilized layer to precipitate the enzyme reaction product on the antibody immobilized layer, allowing to totally reflect a light impinged on the sensor chip from the outside at an interface between the optical waveguide layer and the antibody immobilized layer, and observing to a physical value of the totally reflected light.

公开(公告)号：US20120183614A1

公开(公告)日：2012-07-19

申请号：US13499489

申请日：2009-10-06

申请人： Koji Yanae ,  Shinpei Kawakami ,  Masatoshi Kato ,  Yuko Setoguchi ,  Masanori Sugitani

发明人： Koji Yanae ,  Shinpei Kawakami ,  Masatoshi Kato ,  Yuko Setoguchi ,  Masanori Sugitani

IPC分类号： A61K9/36 ,  C07C229/24 ,  A61K36/752 ,  A61K31/35 ,  C07C53/126 ,  A61K31/195 ,  A61K31/20 ,  C07C229/22 ,  A61K36/82

CPC分类号： A23L2/06 ,  A23F3/163 ,  A23L2/02 ,  A23L2/52 ,  A23L29/035 ,  A23L29/04 ,  A23L33/105 ,  A23L33/12 ,  A23V2002/00 ,  A23V2250/2132 ,  A23V2250/214 ,  A23V2250/21162 ,  A23V2250/0642 ,  A23V2250/061 ,  A23V2250/044 ,  A23V2250/1884

摘要： Provided are a polyphenol compound absorption promoter which is widely applicable to foods and drinks over a wide range, and a method for producing a food, drink or food material containing a polyphenol compound. The polyphenol compound absorption promoter comprises, as the active ingredient, at least one member selected from the group consisting of serine, aspartic acid, malic acid, capric acid, lauric acid, grapefruit juice and Camellia sinensis (L.) O. Kuntze extract. The method for producing a food, drink or food material containing a polyphenol compound comprises: adding at least one member selected from the group consisting of serine, aspartic acid, malic acid, capric acid, lauric acid, grapefruit juice and Camellia sinensis (L.) O. Kuntze extract to a starting material for a food or drink or a starting material for a food material containing a polyphenol compound; or adding a polyphenol compound to a starting material for a food or drink or a starting material for a food material containing at least one member selected from the group consisting of serine, aspartic acid, malic acid, capric acid, lauric acid, grapefruit juice and Camellia sinensis (L.) O. Kuntze extract.

摘要翻译： 提供广泛适用于广泛范围的食品和饮料的多酚化合物吸收促进剂，以及含有多酚化合物的食品，饮料或食品的制造方法。 多酚化合物吸收促进剂包含选自丝氨酸，天冬氨酸，苹果酸，癸酸，月桂酸，葡萄柚汁和山茶（L.）O.Kuntze提取物中的至少一种作为活性成分的活性成分。 含有多酚化合物的食品，饮料或食品的制造方法包括：添加至少一种选自丝氨酸，天冬氨酸，苹果酸，癸酸，月桂酸，葡萄柚汁，山茶（L. ）O.Kuntze提取物用于食品或饮料的起始材料或含有多酚化合物的食品的起始材料; 或者将多酚化合物添加到食品或饮料的起始原料中，或者是含有选自丝氨酸，天冬氨酸，苹果酸，癸酸，月桂酸，葡萄柚汁等的至少一种的食品的原料。 山茶（L.）O. Kuntze提取物。