公开(公告)号：US07091018B2

公开(公告)日：2006-08-15

申请号：US10297599

申请日：2001-06-12

申请人： Tsutomu Fujiwara ,  Takashi Okamoto ,  Masashi Niimi ,  Hiroyuki Kyushiki ,  Yasuchika Yamamoto ,  Atsunori Ueyama

发明人： Tsutomu Fujiwara ,  Takashi Okamoto ,  Masashi Niimi ,  Hiroyuki Kyushiki ,  Yasuchika Yamamoto ,  Atsunori Ueyama

IPC分类号： C12N9/10 ,  C12N1/12 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12N9/1096 ,  A61K48/00

摘要： The present invention is drawn to a gene comprising a polynucleotide encoding a polypeptide composed of an amino acid sequence represented by SEQ ID NO: 1; a gene expression product produced through expression of the gene; a recombinant expression vector including the gene; a host cell (transformant) harboring the recombinant expression vector; a protein composed of an amino acid having an amino acid sequence represented by SEQ ID NO: 1; a therapeutic or preventive composition for hypoglycemia containing as an active ingredient the above-mentioned gene or protein; and an antibody capable of binding to the protein. Through use of the gene or an expression product thereof of the present invention, it is possible to elucidate the pathology of diabetes and develop drugs for treatment and prevention of diabetes via a new action mechanism.

摘要翻译： 本发明涉及包含编码由SEQ ID NO：1所示的氨基酸序列构成的多肽的多核苷酸的基因; 通过表达基因产生的基因表达产物; 包含该基因的重组表达载体; 携带重组表达载体的宿主细胞（转化体） 由具有SEQ ID NO：1所示的氨基酸序列的氨基酸组成的蛋白质; 含有作为上述基因或蛋白质的活性成分的低血糖的治疗或预防组合物; 和能够结合蛋白质的抗体。 通过使用本发明的基因或其表达产物，可以通过新的作用机制阐明糖尿病的病理学并开发用于治疗和预防糖尿病的药物。