公开(公告)号：US08066278B2

公开(公告)日：2011-11-29

申请号：US12556902

申请日：2009-09-10

申请人： Tsuyoshi Sanada ,  Kiyoshi Morino ,  Tsutomu Fujiwara ,  Toshiharu Sekino

发明人： Tsuyoshi Sanada ,  Kiyoshi Morino ,  Tsutomu Fujiwara ,  Toshiharu Sekino

IPC分类号： B65H29/00 ,  B65H5/00

CPC分类号： B65H29/125 ,  B65H31/3027 ,  B65H2301/42122 ,  B65H2301/42262 ,  B65H2511/51 ,  B65H2513/412 ,  Y10S271/902 ,  B65H2220/01 ,  B65H2220/02

摘要： In the state that a preceding sheet awaits at an awaiting position, a pair of conveying rollers are separated from each other, and the front end of a subsequent sheet sent out from a main conveying path passes the gap between the pair of conveying rollers. Based on a configuration that the distance from the trailing end of the subsequent sheet in the conveying direction to the pair of conveying rollers becomes equal to that from the front end of the preceding sheet to the pair of conveying rollers, the preceding sheet and subsequent sheet are sandwiched by the pair of conveying rollers so as to be conveyed in a first direction, thereby making the sheets into a state that the sheets are put on each other. Thereafter, the sheets are conveyed in a second direction by the pair of conveying rollers, so as to be discharged into discharging unit.

摘要翻译： 在前一片材等待在等待位置的状态下，一对输送辊彼此分离，并且从主输送路径发出的后续片材的前端穿过一对输送辊之间的间隙。 基于从后续片材的后端到输送辊的距离与从前一片材的前端到一对输送辊的距离相等的构造，前述片材和随后的片材 被一对输送辊夹持以便沿第一方向输送，从而使纸张成为彼此放置的状态。 此后，通过一对输送辊在第二方向上输送纸张，以便排出到排出单元中。

公开(公告)号：US08048995B2

公开(公告)日：2011-11-01

申请号：US12689917

申请日：2010-01-19

申请人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

发明人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

IPC分类号： C07K16/40 ,  C07K16/00

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421 ,  C12N9/93

摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

摘要翻译： 本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。 基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。 通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

公开(公告)号：US20100048878A1

公开(公告)日：2010-02-25

申请号：US12510074

申请日：2009-07-27

申请人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

发明人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

IPC分类号： C07K16/00 ,  C07K14/435

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421 ,  C12N9/93

摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

摘要翻译： 本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。 基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由该基因编码的人类蛋白质。 通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

公开(公告)号：US07420048B2

公开(公告)日：2008-09-02

申请号：US10342276

申请日：2003-01-15

申请人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

发明人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

IPC分类号： C07H21/04

CPC分类号： C12N9/93 ,  C07K14/47 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421

摘要： An isolated and purified human skeletal muscle-specific ubiquitin-conjugating enzyme comprising the amino acid sequence shown in SEQ ID NO: 22 is disclosed. The use of the genes make it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

摘要翻译： 公开了包含SEQ ID NO：22所示的氨基酸序列的分离和纯化的人骨骼肌特异性泛素缀合酶。 基因的使用使得可以在各种组织中检测到其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。 通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

公开(公告)号：US5831058A

公开(公告)日：1998-11-03

申请号：US820170

申请日：1997-03-19

申请人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

发明人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/47 ,  C12N9/00 ,  C12N9/12 ,  C12N9/64 ,  C12N15/12 ,  C12N15/54 ,  C12N15/55 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/19

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421 ,  C12N9/93

摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

摘要翻译： 本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。 基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。 通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

公开(公告)号：US5594487A

公开(公告)日：1997-01-14

申请号：US322338

申请日：1994-10-13

申请人： Akira Nuita ,  Tsutomu Fujiwara ,  Hisao Suzuki ,  Tsugio Narushima ,  Akira Suzuki ,  Mamoru Tago ,  Eiichi Furuya

发明人： Akira Nuita ,  Tsutomu Fujiwara ,  Hisao Suzuki ,  Tsugio Narushima ,  Akira Suzuki ,  Mamoru Tago ,  Eiichi Furuya

IPC分类号： B41J25/312 ,  B41J25/304

CPC分类号： B41J25/312

摘要： The thermal head supporting device of the invention comprises a pair of positioning members disposed at both sides of a platen, a head press/release mechanism movable toward and away from the platen, and a head unit coupled with the head press/release mechanism. The positioning members are disposed coaxially with the platen. The head unit is formed of a head supporting member removably coupled to the head press/release mechanism with a predetermined play, a thermal head supported on the head supporting member and having a plurality of heating elements arranged in a straight line thereon and in confronting relationship with the platen, and a pair of engagement members attached to both sides of the thermal head adjustably for position, and each of the engagement members has a cutting formed therein allowing each positioning member to be removably fitted therein.

摘要翻译： 本发明的热头支撑装置包括设置在压板两侧的一对定位构件，可朝向和远离压板移动的头部按压/释放机构，以及与头部按压/释放机构联接的头部单元。 定位构件与压板同轴设置。 头单元由头部支撑构件形成，头部支撑构件以预定游隙可拆卸地联接到头部按压/释放机构，热头支撑在头部支撑构件上，并且具有多个沿着直线排列的加热元件，并且面对关系 以及一对接合构件，其可调节地安装在热敏头的两侧用于位置，并且每个接合构件具有形成在其中的切割，允许每个定位构件可移除地装配在其中。

公开(公告)号：US08106171B2

公开(公告)日：2012-01-31

申请号：US12977497

申请日：2010-12-23

申请人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

发明人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

IPC分类号： C07K14/475

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421 ,  C12N9/93

摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

摘要翻译： 本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。 基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。 通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

公开(公告)号：US20100160611A1

公开(公告)日：2010-06-24

申请号：US12689917

申请日：2010-01-19

申请人： Tsutomu FUJIWARA ,  Takeshi WANTANABE ,  Masato HORIE

发明人： Tsutomu FUJIWARA ,  Takeshi WANTANABE ,  Masato HORIE

IPC分类号： C07K16/18

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421 ,  C12N9/93

摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

摘要翻译： 本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。 基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。 通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

公开(公告)号：US07592438B2

公开(公告)日：2009-09-22

申请号：US11774330

申请日：2007-07-06

申请人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

发明人： Tsutomu Fujiwara ,  Takeshi Watanabe ,  Masato Horie

IPC分类号： C07H21/04

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421 ,  C12N9/93

摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

公开(公告)号：US06376189B1

公开(公告)日：2002-04-23

申请号：US09661468

申请日：2000-09-13

申请人： Tsutomu Fujiwara ,  Takeshi Watanabe

发明人： Tsutomu Fujiwara ,  Takeshi Watanabe

IPC分类号： C07H2104

CPC分类号： C12N9/93 ,  C07K14/47 ,  C07K14/4705 ,  C12N9/1205 ,  C12N9/6421

摘要： An isolated nucleic acid molecule encoding human skeletal muscle-specific ubiquitin-conjugating enzyme and comprising a nucleotide sequence coding for the amino acid sequence shown in SEQ ID NO:22 is disclosed. The isolation of this molecule makes it possible to detect its expression in various tissues, analyze its structure and function, and produce the human proteins encoded by this molecule by the technology of genetic engineering. In this way, it is possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the molecule, for example hereditary diseases and cancer, and diagnose and treat such diseases.

摘要翻译： 公开了编码人骨骼肌特异性泛素缀合酶的分离的核酸分子，其含有编码SEQ ID NO：22所示的氨基酸序列的核苷酸序列。 该分子的分离使得可以通过遗传工程技术检测其在各种组织中的表达，分析其结构和功能，并产生由该分子编码的人类蛋白质。 以这种方式，可以分析相应的表达产物，阐明与分子相关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。