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    HETERO COMPOUND
    1.
    发明申请
    HETERO COMPOUND 有权
    HETERO化合物

    公开(公告)号：US20100168159A1

    公开(公告)日：2010-07-01

    申请号：US12696327

    申请日：2010-01-29

    申请人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    发明人： Hironori Harada ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC分类号： A61K31/4439 ,  A61K31/4709 ,  C07D471/04 ,  C07D413/14 ,  A61P35/02 ,  A61P37/06 ,  A61P29/00 ,  A61P9/10 ,  A61P35/00

    CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D471/04

    摘要： [Problems]To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.[Means for solving]Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    摘要翻译： [问题]提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1激动剂 活动。 [解决方法]由于本发明的化合物具有S1P1激动剂活性，因此可用作由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的活性成分，例如自身免疫性疾病如移植排斥反应 器官移植，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺功能障碍 哮喘，特应性皮炎，炎症性肠病，动脉粥样硬化，局部缺血再灌注损伤，炎症性疾病等疾病，以及癌症，白血病等细胞异常生长或积累引起的疾病。

    HETERO COMPOUND
    4.
    发明申请
    HETERO COMPOUND 有权
    HETERO化合物

    公开(公告)号：US20090076070A1

    公开(公告)日：2009-03-19

    申请号：US12244102

    申请日：2008-10-02

    申请人： Hironori HARADA ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    发明人： Hironori HARADA ,  Kazuyuki Hattori ,  Kazuya Fujita ,  Masataka Morita ,  Sunao Imada ,  Yoshito Abe ,  Hiromichi Itani ,  Tatsuaki Morokata ,  Hideo Tsutsumi

    IPC分类号： A61K31/4245 ,  C07D413/14 ,  A61K31/437 ,  A61P35/02 ,  A61P19/02 ,  A61P1/00 ,  A61P9/10 ,  A61P37/06 ,  A61P35/00 ,  A61K31/4709

    CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D471/04

    摘要： [Problems] To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.[Means for Solving] Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    摘要翻译： [问题]提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1激动剂 活动。 [解决手段]由于本发明的化合物具有S1P1激动剂活性，因此可用作由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的活性成分，例如自身免疫性疾病例如移植排斥反应 器官移植，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺功能障碍 哮喘，特应性皮炎，炎症性肠病，动脉粥样硬化，局部缺血再灌注损伤，炎症性疾病等疾病，以及癌症，白血病等细胞异常生长或积累引起的疾病。

    Thiazole Derivatives Having Vap-1 Inhibitory Activity
    6.
    发明申请
    Thiazole Derivatives Having Vap-1 Inhibitory Activity 审中-公开
    具有Vap-1抑制活性的噻唑衍生物

    公开(公告)号：US20070254931A1

    公开(公告)日：2007-11-01

    申请号：US11572772

    申请日：2005-07-27

    申请人： Takayuki Inoue ,  Takashi Tojo ,  Masataka Morita

    发明人： Takayuki Inoue ,  Takashi Tojo ,  Masataka Morita

    IPC分类号： A61K31/426 ,  A61P19/02 ,  A61P19/08 ,  A61P3/10 ,  A61P9/10 ,  C07D277/46

    CPC分类号： C07D277/46

    摘要： A compound of the formula (I), (II), (III) or (IV): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

    摘要翻译： 式（I），（II），（III）或（IV）的化合物：其中每个符号如说明书中所定义，或其药学上可接受的盐可用作血管粘附蛋白-1（VAP-1） 抑制剂，药物组合物，预防或治疗VAP-1相关疾病，特别是黄斑水肿的方法，该方法包括向受试者施用有效量的化合物或其药学上可接受的盐等。

    Culture tube and angle rotor receiving the tube in centrifuge
    7.
    发明授权
    Culture tube and angle rotor receiving the tube in centrifuge 有权
    培养管和角转子在离心机中接收管

    公开(公告)号：US07214177B2

    公开(公告)日：2007-05-08

    申请号：US10422852

    申请日：2003-04-25

    申请人： Masaharu Aizawa ,  Masataka Morita

    发明人： Masaharu Aizawa ,  Masataka Morita

    IPC分类号： B04B5/02

    CPC分类号： B01L3/5021 ,  B01L3/50825 ,  B04B5/0414 ,  C12M23/08 ,  C12M23/38 ,  C12M33/10

    摘要： A culture/centrifugal tube includes a tube and a cap. The cap has a disk portion and an annular portion that define an annular groove therebetween. The annular groove opens at a position level with the surface of the disk portion. The open end of the tube extends into the annular groove, with the open end of the vessel in abutment against the surface of the disk portion when the cap is fully engaged on the tube. An angle rotor that is used in a centrifuge is formed with an accommodation hole that receives the culture/centrifugal tube. The accommodation hole including a smaller-diameter tube accommodating portion that accommodates the tube and a larger-diameter cap accommodating portion that accommodates the cap. The cap accommodating portion includes a region that entirely encompasses a corresponding portion of the outer periphery of the annular portion of the cap.

    摘要翻译： 培养/离心管包括管和帽。 盖具有在其间限定环形槽的圆盘部分和环形部分。 环形槽在与盘部分的表面的位置水平位置处打开。 管的开口端延伸到环形槽中，当盖完全接合在管上时，容器的开口端抵靠盘部分的表面。 在离心机中使用的角度转子形成有容纳培养/离心管的容纳孔。 容纳孔包括容纳管的较小直径的管容纳部分和容纳盖的较大直径的盖容纳部分。 盖容纳部分包括完全包围盖的环形部分的外周的相应部分的区域。