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公开(公告)号：US11309574B2
公开(公告)日：2022-04-19
申请号：US14947620
申请日：2015-11-20
Applicant: Eric Duoss , Juergen Biener , Patrick Campbell , Julie A. Jackson , Geoffrey M. Oxberry , Christopher Spadaccini , Michael Stadermann , Cheng Zhu , Bradley Trembacki , Jayathi Murthy , Matthew Merrill
Inventor： Eric Duoss , Juergen Biener , Patrick Campbell , Julie A. Jackson , Geoffrey M. Oxberry , Christopher Spadaccini , Michael Stadermann , Cheng Zhu , Bradley Trembacki , Jayathi Murthy , Matthew Merrill
Abstract: The present disclosure relates to an electrical energy storage apparatus which forms an interpenetrating, three dimensional structure. The structure may have a first non-planar channel filled with an anode material to form an anode, and a second non-planar channel adjacent the first non-planar channel filled with a cathode material to form a cathode. A third non-planar channel may be formed adjacent the first and second non-planar channels and filled with an electrolyte. The first, second and third channels are formed so as to be interpenetrating and form a spatially dense, three dimensional structure. A first current collector is in communication with the first non-planar channel and forms a first electrode, while a second current collector is in communication with the second non-planar channel and forms a second electrode. A separator layers separates the current collectors.
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公开(公告)号：US20170149083A1
公开(公告)日：2017-05-25
申请号：US14947620
申请日：2015-11-20
Applicant: Eric DUOSS , Juergen BIENER , Patrick CAMPBELL , Julie A. JACKSON , Geoffrey M. OXBERRY , Christopher SPADACCINI , Michael STADERMANN , Cheng ZHU , Bradley TREMBACKI , Jayathi MURTHY , Matthew MERRILL
Inventor： Eric DUOSS , Juergen BIENER , Patrick CAMPBELL , Julie A. JACKSON , Geoffrey M. OXBERRY , Christopher SPADACCINI , Michael STADERMANN , Cheng ZHU , Bradley TREMBACKI , Jayathi MURTHY , Matthew MERRILL
CPC classification number: H01M10/02 , B33Y80/00 , H01G11/26 , H01G11/28 , H01G11/52 , H01M4/02 , H01M10/04
Abstract: The present disclosure relates to an electrical energy storage apparatus which forms an interpenetrating, three dimensional structure. The structure may have a first non-planar channel filled with an anode material to form an anode, and a second non-planar channel adjacent the first non-planar channel filled with a cathode material to form a cathode. A third non-planar channel may be formed adjacent the first and second non-planar channels and filled with an electrolyte. The first, second and third channels are formed so as to be interpenetrating and form a spatially dense, three dimensional structure. A first current collector is in communication with the first non-planar channel and forms a first electrode, while a second current collector is in communication with the second non-planar channel and forms a second electrode. A separator layers separates the current collectors.
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公开(公告)号：US08440822B2
公开(公告)日：2013-05-14
申请号：US13557049
申请日：2012-07-24
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US20130005964A1
公开(公告)日：2013-01-03
申请号：US13557049
申请日：2012-07-24
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12 , C07D239/42 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：US20110166120A1
公开(公告)日：2011-07-07
申请号：US13045923
申请日：2011-03-11
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: A61K31/397 , C07D401/12 , A61K31/506 , A61K31/497 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/496 , A61P35/00
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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Patent Agency Ranking
公开(公告)号：US20100035873A1
公开(公告)日：2010-02-11
申请号：US12489902
申请日：2009-06-23
Applicant: Patrick Verhoest , Matthew Merrill Hayward , Vinod Parikh , Stanton Furst McHardy , Stafford McLean
Inventor： Patrick Verhoest , Matthew Merrill Hayward , Vinod Parikh , Stanton Furst McHardy , Stafford McLean
IPC: A61K31/535 , C07D401/02 , A61K31/4439 , C07D265/30
CPC classification number: C07D207/48 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/48 , C07D213/71 , C07D265/30 , C07D295/26 , C07D305/06 , C07D307/22 , C07D309/14 , C07D401/12
Abstract: The invention relates to derivatives of a compound of formula I: wherein R1 to R7 and X1 to X6 are as defined herein.The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid receptors (KORs). Specifically, the compounds are selective antagonists of KORs and are highly selective to KORs relative to mu and delta opioid receptors.
Abstract translation: 本发明涉及式I化合物的衍生物：其中R 1至R 7和X 1至X 6如本文所定义。 本发明涉及其用于治疗由κ阿片受体介导的疾病，病症和/或病症（KOR）的用途。 具体地说，这些化合物是KORs的选择性拮抗剂，相对于mu和δ阿片样物质受体，对KORs具有高选择性。
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公开(公告)号：US20090054395A1
公开(公告)日：2009-02-26
申请号：US12105151
申请日：2008-04-17
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: A61K31/506 , A61P35/00 , C07D401/12 , C07D403/12 , C07D239/48 , A61K31/497 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/5377
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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8.发明申请公开(公告)号：US20140100368A1
公开(公告)日：2014-04-10
申请号：US13853483
申请日：2013-03-29
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D241/20
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US08247411B2
公开(公告)日：2012-08-21
申请号：US13045923
申请日：2011-03-11
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12 , A61K31/506
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US07928109B2
公开(公告)日：2011-04-19
申请号：US12105151
申请日：2008-04-17
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12 , A61K31/506
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法，以及含有这些化合物的药物组合物。
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