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公开(公告)号：US08440822B2
公开(公告)日：2013-05-14
申请号：US13557049
申请日：2012-07-24
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US20130005964A1
公开(公告)日：2013-01-03
申请号：US13557049
申请日：2012-07-24
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12 , C07D239/42 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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3.发明申请公开(公告)号：US20140100368A1
公开(公告)日：2014-04-10
申请号：US13853483
申请日：2013-03-29
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D241/20
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US08247411B2
公开(公告)日：2012-08-21
申请号：US13045923
申请日：2011-03-11
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12 , A61K31/506
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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Patent Agency Ranking
公开(公告)号：US07928109B2
公开(公告)日：2011-04-19
申请号：US12105151
申请日：2008-04-17
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: C07D239/48 , C07D403/12 , A61K31/506
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：US06867230B2
公开(公告)日：2005-03-15
申请号：US09872731
申请日：2001-06-01
Applicant: Matthew Merrill Hayward , Michael S. Visser , Robert G. Linde, II , Takushi Kaneko
Inventor： Matthew Merrill Hayward , Michael S. Visser , Robert G. Linde, II , Takushi Kaneko
IPC: A61K31/357 , A61K31/443 , A61K31/70 , A61K31/7004 , A61K31/7034 , A61P31/04 , A61P31/10 , A61P33/02 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D453/02 , C07D487/08 , C07D521/00 , C07H15/203 , A61K31/36 , C07D317/66
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08 , C07D405/14 , C07D407/12 , C07D407/14 , C07D453/02 , C07D487/08 , C07H15/203
Abstract: This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3 and R10 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1, methods of treating bacterial and protozoal infections by administering the compounds of formula 1.
Abstract translation: 本发明涉及式的化合物及其药学上可接受的盐，前药和溶剂合物，其中R 1，R 2，R 3和R 10如本文所定义。 式1的化合物是可用于治疗各种细菌和原生动物感染的抗细菌剂和抗原虫药，以及与这种感染有关的疾病。 本发明还涉及含有式1化合物的药物组合物，通过施用式1化合物来治疗细菌和原生动物感染的方法。
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公开(公告)号：US20110166120A1
公开(公告)日：2011-07-07
申请号：US13045923
申请日：2011-03-11
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: A61K31/397 , C07D401/12 , A61K31/506 , A61K31/497 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/496 , A61P35/00
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US20100035873A1
公开(公告)日：2010-02-11
申请号：US12489902
申请日：2009-06-23
Applicant: Patrick Verhoest , Matthew Merrill Hayward , Vinod Parikh , Stanton Furst McHardy , Stafford McLean
Inventor： Patrick Verhoest , Matthew Merrill Hayward , Vinod Parikh , Stanton Furst McHardy , Stafford McLean
IPC: A61K31/535 , C07D401/02 , A61K31/4439 , C07D265/30
CPC classification number: C07D207/48 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/48 , C07D213/71 , C07D265/30 , C07D295/26 , C07D305/06 , C07D307/22 , C07D309/14 , C07D401/12
Abstract: The invention relates to derivatives of a compound of formula I: wherein R1 to R7 and X1 to X6 are as defined herein.The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid receptors (KORs). Specifically, the compounds are selective antagonists of KORs and are highly selective to KORs relative to mu and delta opioid receptors.
Abstract translation: 本发明涉及式I化合物的衍生物：其中R 1至R 7和X 1至X 6如本文所定义。 本发明涉及其用于治疗由κ阿片受体介导的疾病，病症和/或病症（KOR）的用途。 具体地说，这些化合物是KORs的选择性拮抗剂，相对于mu和δ阿片样物质受体，对KORs具有高选择性。
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公开(公告)号：US20090054395A1
公开(公告)日：2009-02-26
申请号：US12105151
申请日：2008-04-17
Applicant: Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
Inventor： Michael Joseph Luzzio , Kevin Daniel Freeman-Cook , Samit Kumar Bhattacharya , Matthew Merrill Hayward , Catherine Angela Hulford , Christopher Lowell Autry , Xumiao Zhao , Jun Xiao , Kendra Louise Nelson
IPC: A61K31/506 , A61P35/00 , C07D401/12 , C07D403/12 , C07D239/48 , A61K31/497 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/5377
CPC classification number: C07D401/12 , C07D239/48 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D475/00
Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及式I化合物，其中R 1至R 6，A，B，n和m如本文所定义。 这种新型磺酰基酰胺衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。
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