公开(公告)号：US20110112051A1

公开(公告)日：2011-05-12

申请号：US13006363

申请日：2011-01-13

Applicant: Heiko KROTH ,  Tim Feuerstein ,  Frank Richter ,  Jürgen Boer ,  Michael Essers ,  Bert Nolte ,  Matthias Schneider ,  Matthias Hochguertel ,  Fritz-Frieder Frickel ,  Arthur Taveras ,  Christoph Steeneck

Inventor： Heiko KROTH ,  Tim Feuerstein ,  Frank Richter ,  Jürgen Boer ,  Michael Essers ,  Bert Nolte ,  Matthias Schneider ,  Matthias Hochguertel ,  Fritz-Frieder Frickel ,  Arthur Taveras ,  Christoph Steeneck

IPC: A61K31/41 ,  C07D403/12 ,  C07D413/14 ,  A61K31/5377 ,  C07D403/14 ,  C07D207/16 ,  A61K31/40 ,  C07F5/02 ,  A61K31/69 ,  C07D487/08 ,  A61K31/407 ,  C07D209/52 ,  A61K31/403 ,  A61K31/4196 ,  C07D413/12 ,  A61K31/4245 ,  A61K31/496 ,  C07D401/14 ,  A61K31/4545 ,  A61P3/10

CPC classification number: C07D207/16 ,  C07D209/02 ,  C07D209/52 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D487/08 ,  C07D495/04

Abstract: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

Abstract translation: 本发明一般涉及吡咯烷和噻唑烷DPP-IV抑制剂化合物。 本发明还提供了用于制备这种化合物的合成方法，使用这些化合物抑制DPP-IV的方法和含有它们的药物制剂用于治疗DPP-IV介导的疾病，特别是2型糖尿病。

公开(公告)号：US20060270701A1

公开(公告)日：2006-11-30

申请号：US11409481

申请日：2006-04-21

Applicant: Heiko Kroth ,  Tim Feuerstein ,  Frank Richter ,  Jurgen Boer ,  Michael Essers ,  Bert Nolte ,  Matthias Schneider ,  Matthias Hochguertel ,  Fritz-Frieder Frickel ,  Arthur Taveras

Inventor： Heiko Kroth ,  Tim Feuerstein ,  Frank Richter ,  Jurgen Boer ,  Michael Essers ,  Bert Nolte ,  Matthias Schneider ,  Matthias Hochguertel ,  Fritz-Frieder Frickel ,  Arthur Taveras

IPC: A61K31/4745 ,  A61K31/407 ,  A61K31/41 ,  C07D471/02 ,  C07D403/02

CPC classification number: C07D207/16 ,  C07D209/02 ,  C07D209/52 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D487/08 ,  C07D495/04

Abstract: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

公开(公告)号：US20100009961A1

公开(公告)日：2010-01-14

申请号：US12492254

申请日：2009-06-26

Applicant: Heiko Kroth ,  Tim Feuerstein ,  Frank Richter ,  Jurgen Boer ,  Michael Essers ,  Bert Nolte ,  Matthias Schneider ,  Matthias Hochguertel ,  Fritz-Frieder Frickel ,  Arthur Taveras ,  Christoph Steeneck

Inventor： Heiko Kroth ,  Tim Feuerstein ,  Frank Richter ,  Jurgen Boer ,  Michael Essers ,  Bert Nolte ,  Matthias Schneider ,  Matthias Hochguertel ,  Fritz-Frieder Frickel ,  Arthur Taveras ,  Christoph Steeneck

IPC: A61K31/397 ,  A61K31/5377 ,  A61K31/41 ,  A61K31/40 ,  C07D413/14 ,  C07D403/02 ,  C07D207/00

CPC classification number: C07D207/16 ,  C07D209/02 ,  C07D209/52 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D487/08 ,  C07D495/04

Abstract: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

Abstract translation: 本发明一般涉及吡咯烷和噻唑烷DPP-IV抑制剂化合物。 本发明还提供了用于制备这种化合物的合成方法，使用这些化合物抑制DPP-IV的方法和含有它们的药物制剂用于治疗DPP-IV介导的疾病，特别是2型糖尿病。

公开(公告)号：US20070155738A1

公开(公告)日：2007-07-05

申请号：US11602140

申请日：2006-11-20

Applicant: Christoph Steeneck ,  Christian Gege ,  Frank Richter ,  Heiko Kroth ,  Matthias Hochguertel ,  Michael Essers ,  Joshua Van Veldhuizen ,  Bert Nolte ,  Brian Gallagher ,  Tim Feuerstein ,  Matthias Schneider ,  Torsten Arndt ,  Hongbo Deng ,  Ralf Biesinger ,  Xinyuan Wu ,  Harald Bluhm ,  Irving Sucholeiki ,  Arthur Taveras

Inventor： Christoph Steeneck ,  Christian Gege ,  Frank Richter ,  Heiko Kroth ,  Matthias Hochguertel ,  Michael Essers ,  Joshua Van Veldhuizen ,  Bert Nolte ,  Brian Gallagher ,  Tim Feuerstein ,  Matthias Schneider ,  Torsten Arndt ,  Hongbo Deng ,  Ralf Biesinger ,  Xinyuan Wu ,  Harald Bluhm ,  Irving Sucholeiki ,  Arthur Taveras

IPC: A61K31/538 ,  A61K31/5377 ,  A61K31/519 ,  C07D491/04 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract translation: 本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地，本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物，其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。

公开(公告)号：US20070155737A1

公开(公告)日：2007-07-05

申请号：US11602116

申请日：2006-11-20

Applicant: Brian Gallagher ,  Joshua Van Veldhuizen ,  Xinyuan Wu ,  Hongbo Deng ,  Irving Sucholeiki ,  Matthias Hochguertel ,  Harald Bluhm ,  Arthur Taveras

Inventor： Brian Gallagher ,  Joshua Van Veldhuizen ,  Xinyuan Wu ,  Hongbo Deng ,  Irving Sucholeiki ,  Matthias Hochguertel ,  Harald Bluhm ,  Arthur Taveras

IPC: A61K31/5377 ,  C07D491/04 ,  C07D487/04 ,  A61K31/538 ,  A61K31/519

CPC classification number: C07D487/04

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic ADAMTS-4 inhibiting compounds.

Abstract translation: 本发明一般涉及含酰胺基的药物，尤其涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地说，本发明提供了一类新型的异双环ADAMTS-4抑制化合物。

公开(公告)号：US20060293345A1

公开(公告)日：2006-12-28

申请号：US11440087

申请日：2006-05-22

Applicant: Christoph Steeneck ,  Christian Gege ,  Frank Richter ,  Matthias Hochguertel ,  Tim Feuerstein ,  Harald Bluhm ,  Irving Sucholeiki ,  Jurgen Boer ,  Xinyuan Wu ,  Matthias Schneider ,  Bert Nolte ,  Brian Gallagher ,  Joshua Van Veldhuizen ,  Hongbo Dong ,  Michael Essers ,  Heiko Kroth ,  Andrew Kiely ,  Timothy Powers ,  Arthur Taveras

Inventor： Christoph Steeneck ,  Christian Gege ,  Frank Richter ,  Matthias Hochguertel ,  Tim Feuerstein ,  Harald Bluhm ,  Irving Sucholeiki ,  Jurgen Boer ,  Xinyuan Wu ,  Matthias Schneider ,  Bert Nolte ,  Brian Gallagher ,  Joshua Van Veldhuizen ,  Hongbo Dong ,  Michael Essers ,  Heiko Kroth ,  Andrew Kiely ,  Timothy Powers ,  Arthur Taveras

IPC: A61K31/519 ,  C07D491/04 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 inhibitors.

Abstract translation: 本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地说，本发明提供了一类新型的杂双环MMP-13抑制化合物，其表现出与目前已知的MMP-13抑制剂有关的效力。