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公开(公告)号:US20060293345A1
公开(公告)日:2006-12-28
申请号:US11440087
申请日:2006-05-22
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
IPC分类号: A61K31/519 , C07D491/04 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地说,本发明提供了一类新型的杂双环MMP-13抑制化合物,其表现出与目前已知的MMP-13抑制剂有关的效力。
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公开(公告)号:US20070155738A1
公开(公告)日:2007-07-05
申请号:US11602140
申请日:2006-11-20
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/538 , A61K31/5377 , A61K31/519 , C07D491/04 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US20080161300A1
公开(公告)日:2008-07-03
申请号:US12001041
申请日:2007-12-07
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/536 , A61K31/519 , C07D265/36 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US20060173183A1
公开(公告)日:2006-08-03
申请号:US11324037
申请日:2005-12-30
申请人: Timothy Powers , Christoph Steeneck , Ralf Biesinger , Harald Bluhm , Hongbo Deng , Rory Dodd , Brian Gallagher , Christian Gege , Matthias Hochgurtel , Andrew Kiely , Frank Richter , Matthias Schneider , Irving Sucholeiki , Joshua Van Veldhuizen , Xinyuan Wu , Arthur Taveras
发明人: Timothy Powers , Christoph Steeneck , Ralf Biesinger , Harald Bluhm , Hongbo Deng , Rory Dodd , Brian Gallagher , Christian Gege , Matthias Hochgurtel , Andrew Kiely , Frank Richter , Matthias Schneider , Irving Sucholeiki , Joshua Van Veldhuizen , Xinyuan Wu , Arthur Taveras
IPC分类号: C07D417/02 , C07D403/02 , C07D413/02
CPC分类号: C07D239/28 , C07D239/30 , C07D239/42 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.
摘要翻译: 本发明一般涉及含有双酰胺基团的药物,特别涉及多元双酰胺MMP-13抑制剂化合物。 更具体地,本发明提供了一类新的MMP-13抑制化合物,其包含与杂环部分组合的嘧啶基双酰胺基团,其相对于目前已知的含有MMP-1的双酰胺基团显示增加的效力和溶解度, 13抑制剂。
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公开(公告)号:US20100009961A1
公开(公告)日:2010-01-14
申请号:US12492254
申请日:2009-06-26
申请人: Heiko Kroth , Tim Feuerstein , Frank Richter , Jurgen Boer , Michael Essers , Bert Nolte , Matthias Schneider , Matthias Hochguertel , Fritz-Frieder Frickel , Arthur Taveras , Christoph Steeneck
发明人: Heiko Kroth , Tim Feuerstein , Frank Richter , Jurgen Boer , Michael Essers , Bert Nolte , Matthias Schneider , Matthias Hochguertel , Fritz-Frieder Frickel , Arthur Taveras , Christoph Steeneck
IPC分类号: A61K31/397 , A61K31/5377 , A61K31/41 , A61K31/40 , C07D413/14 , C07D403/02 , C07D207/00
CPC分类号: C07D207/16 , C07D209/02 , C07D209/52 , C07D401/12 , C07D403/12 , C07D413/12 , C07D487/08 , C07D495/04
摘要: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.
摘要翻译: 本发明一般涉及吡咯烷和噻唑烷DPP-IV抑制剂化合物。 本发明还提供了用于制备这种化合物的合成方法,使用这些化合物抑制DPP-IV的方法和含有它们的药物制剂用于治疗DPP-IV介导的疾病,特别是2型糖尿病。
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公开(公告)号:US20110112051A1
公开(公告)日:2011-05-12
申请号:US13006363
申请日:2011-01-13
申请人: Heiko KROTH , Tim Feuerstein , Frank Richter , Jürgen Boer , Michael Essers , Bert Nolte , Matthias Schneider , Matthias Hochguertel , Fritz-Frieder Frickel , Arthur Taveras , Christoph Steeneck
发明人: Heiko KROTH , Tim Feuerstein , Frank Richter , Jürgen Boer , Michael Essers , Bert Nolte , Matthias Schneider , Matthias Hochguertel , Fritz-Frieder Frickel , Arthur Taveras , Christoph Steeneck
IPC分类号: A61K31/41 , C07D403/12 , C07D413/14 , A61K31/5377 , C07D403/14 , C07D207/16 , A61K31/40 , C07F5/02 , A61K31/69 , C07D487/08 , A61K31/407 , C07D209/52 , A61K31/403 , A61K31/4196 , C07D413/12 , A61K31/4245 , A61K31/496 , C07D401/14 , A61K31/4545 , A61P3/10
CPC分类号: C07D207/16 , C07D209/02 , C07D209/52 , C07D401/12 , C07D403/12 , C07D413/12 , C07D487/08 , C07D495/04
摘要: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.
摘要翻译: 本发明一般涉及吡咯烷和噻唑烷DPP-IV抑制剂化合物。 本发明还提供了用于制备这种化合物的合成方法,使用这些化合物抑制DPP-IV的方法和含有它们的药物制剂用于治疗DPP-IV介导的疾病,特别是2型糖尿病。
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公开(公告)号:US20080176870A1
公开(公告)日:2008-07-24
申请号:US11986622
申请日:2007-11-20
申请人: Bert Nolte , Irving Sucholeiki , Tim Feuerstein , Brian M. Gallagher , Xinyuan Wu , Christoph Steeneck , Christian Gege , Hongbo Deng , Joshua Van Veldhuizen , Arthur Taveras
发明人: Bert Nolte , Irving Sucholeiki , Tim Feuerstein , Brian M. Gallagher , Xinyuan Wu , Christoph Steeneck , Christian Gege , Hongbo Deng , Joshua Van Veldhuizen , Arthur Taveras
IPC分类号: A61K31/495 , C07D487/04 , A61P19/02 , A61P29/00 , A61P9/10
CPC分类号: C07D487/04
摘要: The present invention relates generally to heterobicyclic containing pharmaceutical agents, and in particular, to heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic metalloprotease inhibiting compounds that exhibit an increased potency in relation to currently known metalloprotease inhibitors.
摘要翻译: 本发明一般涉及含杂环的药物,特别是涉及杂双环金属蛋白酶抑制剂化合物。 更具体地,本发明提供了一类新型的杂双环金属蛋白酶抑制化合物,其与当前已知的金属蛋白酶抑制剂相比表现出增加的效力。
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公开(公告)号:US20060270701A1
公开(公告)日:2006-11-30
申请号:US11409481
申请日:2006-04-21
申请人: Heiko Kroth , Tim Feuerstein , Frank Richter , Jurgen Boer , Michael Essers , Bert Nolte , Matthias Schneider , Matthias Hochguertel , Fritz-Frieder Frickel , Arthur Taveras
发明人: Heiko Kroth , Tim Feuerstein , Frank Richter , Jurgen Boer , Michael Essers , Bert Nolte , Matthias Schneider , Matthias Hochguertel , Fritz-Frieder Frickel , Arthur Taveras
IPC分类号: A61K31/4745 , A61K31/407 , A61K31/41 , C07D471/02 , C07D403/02
CPC分类号: C07D207/16 , C07D209/02 , C07D209/52 , C07D401/12 , C07D403/12 , C07D413/12 , C07D487/08 , C07D495/04
摘要: The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.
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公开(公告)号:US20080021024A1
公开(公告)日:2008-01-24
申请号:US11824525
申请日:2007-06-29
申请人: Irving Sucholeiki , Christian Gege , Brian Gallagher , Timothy Powers , Hongbo Deng , Xinyuan Wu , Christoph Steeneck , Andrew Kiely , Arthur Taveras
发明人: Irving Sucholeiki , Christian Gege , Brian Gallagher , Timothy Powers , Hongbo Deng , Xinyuan Wu , Christoph Steeneck , Andrew Kiely , Arthur Taveras
IPC分类号: C07D239/24 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/536 , A61P17/00 , C12N9/99 , C07D265/36 , A61P19/00 , A61P25/00 , A61P3/00 , A61P9/00
CPC分类号: C07D403/12 , C07D239/38 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: The present invention relates to amide containing aromatic MMP inhibiting compounds with a mono-amide heteroaromatic group, of formulas I and II:
摘要翻译: 本发明涉及具有式I和II的单酰胺杂芳族基团的含酰胺芳香族MMP抑制化合物:
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公开(公告)号:US20070155737A1
公开(公告)日:2007-07-05
申请号:US11602116
申请日:2006-11-20
申请人: Brian Gallagher , Joshua Van Veldhuizen , Xinyuan Wu , Hongbo Deng , Irving Sucholeiki , Matthias Hochguertel , Harald Bluhm , Arthur Taveras
发明人: Brian Gallagher , Joshua Van Veldhuizen , Xinyuan Wu , Hongbo Deng , Irving Sucholeiki , Matthias Hochguertel , Harald Bluhm , Arthur Taveras
IPC分类号: A61K31/5377 , C07D491/04 , C07D487/04 , A61K31/538 , A61K31/519
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic ADAMTS-4 inhibiting compounds.
摘要翻译: 本发明一般涉及含酰胺基的药物,尤其涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地说,本发明提供了一类新型的异双环ADAMTS-4抑制化合物。
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