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公开(公告)号：US09789074B2
公开(公告)日：2017-10-17
申请号：US13819914
申请日：2011-08-31
IPC分类号： A61K31/69 , A61K31/343 , A61K31/665 , A61K31/506 , A61K31/192 , A61K31/185 , A61K31/19 , A61K31/415 , A61K35/12 , A61K45/06
CPC分类号： A61K31/192 , A61K31/185 , A61K31/19 , A61K31/415 , A61K35/12 , A61K45/06
摘要： The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RARγ agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.
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公开(公告)号：US20090275030A1
公开(公告)日：2009-11-05
申请号：US12353382
申请日：2009-01-14
CPC分类号： C07K14/465
摘要： This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.
摘要翻译： 本发明提供了细胞钙化抑制蛋白以及编码蛋白质的基因。 基于发现一种来自鸡的erg基因的c-gerg基因（本文中称为“C-11基因”）的新型同种型基因，已经确定了该基因的核苷酸序列， 的这种基因编码的蛋白质（本文中称为“C-11蛋白质”）已被证实。 此外，已经发现，当将c-g或C-11基因导入成骨细胞时，细胞的钙化被抑制。
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公开(公告)号：US07494970B2
公开(公告)日：2009-02-24
申请号：US10851328
申请日：2004-05-24
IPC分类号： C07K14/00
CPC分类号： C07K14/465
摘要： This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.
摘要翻译： 本发明提供了细胞钙化抑制蛋白以及编码蛋白质的基因。 基于发现一种来自鸡的erg基因的c-gerg基因（本文中称为“C-11基因”）的新型同种型基因，已经确定了该基因的核苷酸序列， 的这种基因编码的蛋白质（本文中称为“C-11蛋白质”）已被证实。 此外，已经发现，当将c-g或C-11基因导入成骨细胞时，细胞的钙化被抑制。
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公开(公告)号：US20140363402A1
公开(公告)日：2014-12-11
申请号：US13819914
申请日：2011-08-31
IPC分类号： A61K31/192 , A61K35/12 , A61K45/06
CPC分类号： A61K31/192 , A61K31/185 , A61K31/19 , A61K31/415 , A61K35/12 , A61K45/06
摘要： The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RARγ agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.
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公开(公告)号：US08318658B2
公开(公告)日：2012-11-27
申请号：US12353382
申请日：2009-01-14
IPC分类号： C07K14/00
CPC分类号： C07K14/465
摘要： This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.
摘要翻译： 本发明提供了细胞钙化抑制蛋白以及编码蛋白质的基因。 基于发现一种来自鸡的erg基因的c-gerg基因（本文中称为C-11基因）的新型同种型基因，已经确定了该基因的核苷酸序列，然后将其表达 已证实由该基因编码的蛋白质（本文称为C-11蛋白质）。 此外，已经发现，当将c-g或C-11基因导入成骨细胞时，细胞的钙化被抑制。
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公开(公告)号：US06294354B1
公开(公告)日：2001-09-25
申请号：US08878177
申请日：1997-06-18
IPC分类号： C12P2186
CPC分类号： C07K14/465
摘要： This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited.
摘要翻译： 本发明提供了细胞钙化抑制蛋白以及编码蛋白质的基因。 基于发现一种来自鸡的erg基因的c-gerg基因（本文中称为“C-11基因”）的新型同种型基因，已经确定了该基因的核苷酸序列， 的这种基因编码的蛋白质（本文中称为“C-11蛋白质”）已被证实。 此外，已经发现，当将c-g或C-11基因导入成骨细胞时，细胞的钙化被抑制。
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7.发明授权Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies 失效维甲酸受体拮抗剂在软骨和骨骼病理治疗中的应用公开(公告)号：US06313168B1
公开(公告)日：2001-11-06
申请号：US09464344
申请日：1999-12-15
IPC分类号： A61K3135
CPC分类号： A61K31/165 , A61K31/07 , A61K31/19 , A61K31/35 , A61K31/38
摘要： The present invention relates to methods for treating cartilage and bone pathologies, including bone growth related diseases such as osteoarthritis, comprising administering therapeutically effective amounts of retinoid receptor antagonists.
摘要翻译： 本发明涉及治疗软骨和骨病变的方法，包括骨生长相关疾病如骨关节炎，包括给予治疗有效量的类视色素受体拮抗剂。
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