公开(公告)号：US20210308599A1

公开(公告)日：2021-10-07

申请号：US17354058

申请日：2021-06-22

申请人： Melvin Hatch ,  Dionex Corporation

发明人： Melvin Hatch ,  Christopher A. Pohl ,  Manikandan Jayaraman

IPC分类号： B01D15/36 ,  B01J41/13 ,  B01J41/20 ,  B01J41/14 ,  B01J41/05

摘要： An ion exchange resin for use as a stationary phase in an ion chromatography column. The ion exchange resin has a negatively charged substrate particle, a positively charged polymer layer bound to the negatively charged substrate particle, a linker, and an ion exchange group. The ion exchange group includes a sulfonamide group and an amine, in which the ion exchange group is coupled to the positively charged polymer layer via the linker. When the sulfonamide is in a neutral form, a positively charged amine group provides retention: while when the sulfonamide is in an anionic form, the sulfonamide anion becomes a counter ion to the positively charged amine group, forming a zwitterion that reduces retention at that site. Accordingly, the retention time is able to be controlled by adjusting the mobile phase pH.