公开(公告)号：US20130107662A1

公开(公告)日：2013-05-02

申请号：US13457468

申请日：2012-04-26

申请人： Meng-Lin Li ,  Po-Hsun Wang

发明人： Meng-Lin Li ,  Po-Hsun Wang

IPC分类号： G03B42/06

CPC分类号： G01N29/0681 ,  G01N29/2418

摘要： Embodiments of the invention provide a photoacoustic microscopy (PAM) system for observing an object. The PAM system includes an optical pickup head, an ultrasonic transducer, and an image generation unit. The optical pickup head emits a laser beam to the object, generates a servo signal based on a reflective light beam received from the object, and positions a focus of the laser beam onto the object based on the servo signal. The ultrasonic transducer detects laser-induced ultrasonic waves leaving the object to generate a PAM imaging signal. The image generation unit generates a PAM image of the object based on the PAM imaging signal.

摘要翻译： 本发明的实施例提供一种用于观察物体的光声显微镜（PAM）系统。 PAM系统包括光学拾取头，超声波换能器和图像生成单元。 光学拾取头向物体发射激光束，根据从物体接收的反射光束产生伺服信号，并且基于伺服信号将激光束的焦点定位在物体上。 超声波换能器检测离开物体的激光感应超声波以产生PAM成像信号。 图像生成单元基于PAM成像信号生成对象的PAM图像。

公开(公告)号：US20110144496A1

公开(公告)日：2011-06-16

申请号：US12891401

申请日：2010-09-27

申请人： Meng-Lin LI ,  Tsai-Chu HSIAO ,  Shin-Cheh CHEN ,  Yao-Yu CHENG ,  Po-Hsun WANG ,  Chih-Tai FAN

发明人： Meng-Lin LI ,  Tsai-Chu HSIAO ,  Shin-Cheh CHEN ,  Yao-Yu CHENG ,  Po-Hsun WANG ,  Chih-Tai FAN

IPC分类号： A61B8/14

CPC分类号： A61B8/0825 ,  A61B5/0091 ,  A61B5/0095 ,  A61B5/7425 ,  A61B8/06 ,  A61B8/13 ,  A61B8/5238

摘要： An imaging method for microcalcification displays microcalcification distribution by acquiring and overlapping a photoacoustic image of microcalcification and an ultrasonic image of tissue. The image acquired by the present invention, in comparison to images acquired by ultrasonic and X-ray mammography, has advantages in no speckle noises, higher optical contrast, higher ultrasonic resolution, and so on. The present invention also has advantage in safety by adopting a light source having no ionizing radiation. An imaging method for diagnosing breast cancer is also herein disclosed.

摘要翻译： 用于微钙化的成像方法通过获取和重叠微钙化的光声图像和组织的超声波图像来显示微钙化分布。 通过本发明获得的图像与通过超声波和X射线乳腺摄影术获得的图像相比，具有无斑点噪声，较高的光学对比度，更高的超声波分辨率等优点。 本发明通过采用不具有电离辐射的光源也具有安全的优点。 本文还公开了用于诊断乳腺癌的成像方法。

公开(公告)号：US20190298298A1

公开(公告)日：2019-10-03

申请号：US16271870

申请日：2019-02-10

申请人： Meng-Lin Li ,  QISDA CORPORATION

发明人： Meng-Lin Li ,  Fu-Yen Kuo ,  Tang-Chen Chang

IPC分类号： A61B8/06 ,  A61B8/00 ,  A61B8/08 ,  A61B5/00

摘要： An ultrasound imaging method includes steps of transmitting a plurality of ultrasound signals by a pulse repetition interval; receiving a plurality of reflected signals of the ultrasound signals; separating a blood flow signal and a clutter signal from the reflected signals by a neural network; calculating a blood flow parameter according to the blood flow signal; determining a blood vessel position according to the blood flow parameter; and adjusting an image signal corresponding to the reflected signals according to the blood flow parameter and the blood vessel position to generate an ultrasound image.

公开(公告)号：US20050228279A1

公开(公告)日：2005-10-13

申请号：US10814959

申请日：2004-03-31

申请人： Kutay Ustuner ,  Pai-Chi Li ,  Meng-Lin Li ,  Lewis Thomas ,  Albert Gee

发明人： Kutay Ustuner ,  Pai-Chi Li ,  Meng-Lin Li ,  Lewis Thomas ,  Albert Gee

IPC分类号： A61B8/14 ,  G01S7/52

CPC分类号： G01S15/8927 ,  G01S7/52049

摘要： Ultrasound imaging adapts as a function of a coherence factor. Various beamforming, image forming or image processing parameters are varied as a function of a coherence factor to improve detail resolution, contrast resolution, dynamic range or SNR. For example, a beamforming parameter such as the transmit or receive aperture size, apodization type or delay is selected to provide maximum coherence. Alternatively or additionally, an image forming parameter, such as the number of beams for coherent synthesis or incoherent compounding, is set as a function of the coherence factor. Alternatively or additionally an image processing parameter such as the dynamic range, linear or nonlinear video filter and/or linear or nonlinear map may also adapt as a function of the coherence factor.

摘要翻译： 超声成像适应相干因子的函数。 各种波束成形，图像形成或图像处理参数作为相干因子的函数而变化，以提高细节分辨率，对比度分辨率，动态范围或SNR。 例如，选择诸如发射或接收孔径大小，变迹类型或延迟的波束形成参数以提供最大相干性。 或者或另外，将诸如用于相干合成或非相干复合的光束的数量的图像形成参数设置为相干因子的函数。 替代地或附加地，诸如动态范围，线性或非线性视频滤波器和/或线性或非线性映射的图像处理参数也可以作为相干因子的函数来适应。

公开(公告)号：US09050022B2

公开(公告)日：2015-06-09

申请号：US12913481

申请日：2010-10-27

申请人： Meng-Lin Li ,  Hao-Li Liu ,  Da-Wei Li

发明人： Meng-Lin Li ,  Hao-Li Liu ,  Da-Wei Li

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61N7/02 ,  A61B19/00

CPC分类号： A61B8/08 ,  A61B2090/378 ,  A61N7/02

摘要： A method for dynamically analyzing distribution variation of scatterers is provided and used for dynamically analyzing changes in two or three dimensional scatterer distribution and concentration of ultrasound data by using probability density function along with a moving window technique. The present invention has advantages in low computation load and may be used for real-time analysis. A method for dynamically detecting thermal ablation area and thermal ablation level and a method for dynamically controlling thermal ablation intensity are also provided for non-invasive detection and thermal ablation.

摘要翻译： 提供动态分析散射体分布变化的方法，用于动态分析二维或三维散射体分布的变化和超声数据的浓度，并利用概率密度函数和移动窗口技术。 本发明具有计算负荷低的优点，可用于实时分析。 还提供了用于动态检测热消融区域和热消融水平的方法以及用于动态控制热消融强度的方法用于非侵入式检测和热消融。

公开(公告)号：US20110306880A1

公开(公告)日：2011-12-15

申请号：US12913481

申请日：2010-10-27

申请人： Meng-Lin LI ,  Hao-Li Liu ,  Da-Wei Li

发明人： Meng-Lin LI ,  Hao-Li Liu ,  Da-Wei Li

IPC分类号： A61B8/14 ,  A61B18/12

CPC分类号： A61B8/08 ,  A61B2090/378 ,  A61N7/02

摘要： A method for dynamically analyzing distribution variation of scatterers is provided and used for dynamically analyzing changes in two or three dimensional scatterer distribution and concentration of ultrasound data by using probability density function along with a moving window technique. The present invention has advantages in low computation load and may be used for real-time analysis. A method for dynamically detecting thermal ablation area and thermal ablation level and a method for dynamically controlling thermal ablation intensity are also provided for non-invasive detection and thermal ablation.

摘要翻译： 提供动态分析散射体分布变化的方法，用于动态分析二维或三维散射体分布的变化和超声数据的浓度，并利用概率密度函数和移动窗口技术。 本发明具有计算负荷低的优点，可用于实时分析。 还提供了用于动态检测热消融区域和热消融水平的方法以及用于动态控制热消融强度的方法用于非侵入式检测和热消融。

公开(公告)号：US07744532B2

公开(公告)日：2010-06-29

申请号：US10814959

申请日：2004-03-31

申请人： Kutay F. Ustuner ,  Pai-Chi Li ,  Meng-Lin Li ,  Tom L. Thomas ,  Albert Gee

发明人： Kutay F. Ustuner ,  Pai-Chi Li ,  Meng-Lin Li ,  Tom L. Thomas ,  Albert Gee

IPC分类号： A61B5/05

CPC分类号： G01S15/8927 ,  G01S7/52049

摘要： Ultrasound imaging adapts as a function of a coherence factor. Various beamforming, image forming or image processing parameters are varied as a function of a coherence factor to improve detail resolution, contrast resolution, dynamic range or SNR. For example, a beamforming parameter such as the transmit or receive aperture size, apodization type or delay is selected to provide maximum coherence. Alternatively or additionally, an image forming parameter, such as the number of beams for coherent synthesis or incoherent compounding, is set as a function of the coherence factor. Alternatively or additionally an image processing parameter such as the dynamic range, linear or nonlinear video filter and/or linear or nonlinear map may also adapt as a function of the coherence factor.

摘要翻译： 超声成像适应相干因子的函数。 各种波束成形，图像形成或图像处理参数作为相干因子的函数而变化，以提高细节分辨率，对比度分辨率，动态范围或SNR。 例如，选择诸如发射或接收孔径大小，变迹类型或延迟的波束成形参数以提供最大相干性。 或者或另外，将诸如用于相干合成或非相干复合的光束的数量的图像形成参数设置为相干因子的函数。 替代地或附加地，诸如动态范围，线性或非线性视频滤波器和/或线性或非线性映射的图像处理参数也可以作为相干因子的函数来适应。