Expression methods
    2.
    发明授权
    Expression methods 有权
    表达方法

    公开(公告)号:US06525241B1

    公开(公告)日:2003-02-25

    申请号:US09355295

    申请日:1999-07-18

    IPC分类号: C12P2100

    摘要: The present invention relates to human bile salt-stimulated lipase (BSSL) obtainable from transgenic sheep. The invention further relates to transgenic sheep whose germ cells and somatic cells contain a recombinant nucleotide molecule comprising a nucleotide sequence encoding for human BSSL. The invention also relates to methods for producing said transgenic animals, as well as to methods for producing human BSSL derived from transgenic animals. In addition, the invention provides the use of compositions comprising BSSL in the treatment of diseases relating to exocrine pancreatic insufficiency, and for improvement of the utilization of dietary lipids in preterm born infants.

    摘要翻译: 本发明涉及可从转基因羊获得的人胆汁盐刺激的脂肪酶(BSSL)。 本发明还涉及其生殖细胞和体细胞含有包含编码人BSSL的核苷酸序列的重组核苷酸分子的转基因绵羊。 本发明还涉及用于生产所述转基因动物的方法,以及用于生产来自转基因动物的人BSSL的方法。 此外,本发明提供了包含BSSL的组合物在治疗与外分泌胰腺功能不全相关的疾病中的用途,以及用于改善早产婴儿中膳食脂质的利用。