公开(公告)号：US20100131525A1

公开(公告)日：2010-05-27

申请号：US12275207

申请日：2008-11-21

申请人： Michael J. Mahan, JR. ,  Tracy Lee Mahan

发明人： Michael J. Mahan, JR. ,  Tracy Lee Mahan

IPC分类号： G06F17/30 ,  G06F3/00 ,  G06F7/00

CPC分类号： G06Q10/10 ,  G06Q10/06

摘要： The systems and methods of the present disclosure provide an authorized user with the ability to input and store past and current racing information and compare that information to a particular characteristic or set of characteristics to prepare reports, objective rating/performance systems, training regimens, value assessments and otherwise compare and analyze the data in real time for a variety of other reasons. The authorized user can access, create performance reports, and/or update data on the proposed system via the web using any device configured to access the Internet including, for example, any stand alone computer, networked device or suitable mobile device.

摘要翻译： 本公开的系统和方法为授权用户提供输入和存储过去和当前赛车信息的能力，并将该信息与特定特征或特征集进行比较以准备报告，客观评级/表现系统，训练方案，价值 评估和其他因素的实时比较和分析数据。 授权用户可以使用配置为访问因特网的任何设备（例如任何独立的计算机，网络设备或合适的移动设备）通过网络访问，创建性能报告和/或更新所提出的系统上的数据。

公开(公告)号：US06365401B1

公开(公告)日：2002-04-02

申请号：US08651155

申请日：1996-05-17

申请人： Michael J. Mahan ,  Christopher P. Conner ,  Douglas M. Heithoff

发明人： Michael J. Mahan ,  Christopher P. Conner ,  Douglas M. Heithoff

IPC分类号： C12N1931

CPC分类号： C07K14/255 ,  A61K39/00 ,  C07K2319/00 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/689 ,  C12Q1/6897 ,  C12Q2600/158

摘要： The present invention relates to a class of microbial coding sequences the transcription or cotranscription of which is specifically induced during microbial infection of a host. These particular coding sequences or defined regions thereof may be used as probes to identify and isolate microbial virulence genes. The products of these virulence genes will provide potential targets for the development of vaccines or antimicrobial agents.

摘要翻译： 本发明涉及一种微生物编码序列，其转录或转录在宿主的微生物感染过程中被特异性诱导。 这些特定的编码序列或其限定的区域可用作鉴定和分离微生物毒力基因的探针。 这些毒力基因的产物将为疫苗或抗微生物剂的开发提供潜在的目标。

公开(公告)号：US07026155B2

公开(公告)日：2006-04-11

申请号：US09928227

申请日：2001-08-09

申请人： Michael J. Mahan ,  Douglas M. Heithoff ,  David A. Low ,  Robert L Sinsheimer

发明人： Michael J. Mahan ,  Douglas M. Heithoff ,  David A. Low ,  Robert L Sinsheimer

IPC分类号： G01N33/53

CPC分类号： A61K39/0275 ,  A61K39/025 ,  A61K39/107 ,  A61K2039/522 ,  Y02A50/472 ,  Y02A50/482 ,  Y02A50/484

摘要： Bacteria and in particular pathogenic bacteria are treated in a manner which alters the bacteria's native level or activity of DNA methyltransferase (Dam). The alteration results in a change in the bacteria's native level of methylation of adenine in a GATC tetranucleotide which inhibits virulence of the bacteria. Thus, compounds which inhibit proliferation of bacteria are useful in treating bacterial infections.

公开(公告)号：US06548246B1

公开(公告)日：2003-04-15

申请号：US09194036

申请日：1998-11-17

申请人： Michael J. Mahan ,  Christopher P. Conner ,  Douglas M. Heithoff

发明人： Michael J. Mahan ,  Christopher P. Conner ,  Douglas M. Heithoff

IPC分类号： C12Q168

CPC分类号： C12Q1/689 ,  C12N15/1034

摘要： The present invention relates to a class of microbial coding sequences the transcription or cotranscription of which is specifically induced during microbial infection of a host. These particular coding sequences or defined regions thereof may be used as probes to identify and isolate microbial virulence genes. The products of these virulence genes will provide potential targets for the development of vaccines or antimicrobial agents.

公开(公告)号：US5434065A

公开(公告)日：1995-07-18

申请号：US58299

申请日：1993-05-06

申请人： Michael J. Mahan ,  John J. Mekalanos ,  James M. Slauch

发明人： Michael J. Mahan ,  John J. Mekalanos ,  James M. Slauch

IPC分类号： C07K14/255 ,  C12N15/10 ,  C12N15/52 ,  C12N15/62 ,  C12N15/90 ,  C12Q1/68 ,  C12N15/09

CPC分类号： C12N15/1082 ,  C07K14/255 ,  C12N15/52 ,  C12N15/62 ,  C12N15/907 ,  C12Q1/6897 ,  C07K2319/00 ,  C07K2319/10 ,  C07K2319/80

摘要： A genetic system termed in vivo expression technology was devised that positively selects for microbial genes that are specifically induced when microbes infect their host. The method of this invention comprises complementing the growth of an auxotrophic or antibiotic sensitive microorganism by integrating an expression vector by way of homologous recombination into the auxotrophic or antibiotic sensitive microorganism's chromosome and inducing the expression of a synthetic operon which encodes transcripts, the expression of which are easily monitored both in vitro and in vivo.

摘要翻译： 设计了一种称为体内表达技术的遗传系统，可以积极选择当微生物感染宿主时特异性诱导的微生物基因。 本发明的方法包括通过将表达载体通过同源重组整合到营养缺陷型或抗生素敏感性微生物的染色体中并诱导编码转录物的合成操纵子的表达来补充营养缺陷型或抗生素敏感性微生物的生长，其表达 在体外和体内均易于监测。