公开(公告)号：US08962267B1

公开(公告)日：2015-02-24

申请号：US13138843

申请日：2010-04-12

申请人： Richard De Wijn ,  Robby Ruijtenbeek ,  Maria Helena Hilhorst ,  Michael Maria Van Den Heuvel ,  Houke Marian Klomp

发明人： Richard De Wijn ,  Robby Ruijtenbeek ,  Maria Helena Hilhorst ,  Michael Maria Van Den Heuvel ,  Houke Marian Klomp

IPC分类号： G01N33/00 ,  C12Q1/48 ,  G01N33/48 ,  C40B30/08 ,  C40B30/06

CPC分类号： G01N33/57423 ,  C12Q1/485 ,  G01N2333/91205 ,  G01N2800/52

摘要： The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non small cell lung cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in samples of said patients.

摘要翻译： 本发明涉及一种用于确定或预测诊断为非小细胞肺癌的患者对靶向药物治疗的反应的方法。 本发明还旨在提供用于预测诊断为非小细胞肺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究所述患者样品中的药物的磷酸化水平及其特征和抑制来测量激酶活性的方法。