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公开(公告)号：US09075061B2
公开(公告)日：2015-07-07
申请号：US13138847
申请日：2010-04-12
申请人： Robby Ruijtenbeek , Maria Helena Hilhorst , Arzu Umar , Johannes Albert Foekens , Johannes Wilhelmus Maria Martens
发明人： Robby Ruijtenbeek , Maria Helena Hilhorst , Arzu Umar , Johannes Albert Foekens , Johannes Wilhelmus Maria Martens
IPC分类号： C12Q1/48 , C40B40/10 , C40B30/08 , G01N33/574 , G01N33/74
CPC分类号： G01N33/57415 , C12Q1/485 , G01N33/74 , G01N2333/723 , G01N2800/52
摘要： The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.
摘要翻译： 本发明涉及确定患有乳腺癌的患者的雌激素受体状态的方法。 本发明还旨在提供用于预测诊断为乳腺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究从诊断为乳腺癌的患者获得的样品中的磷酸化水平和特征来测量激酶活性的方法。
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2.发明申请Method for high throughput cell-based assays using versatile living microarrays 失效使用多功能生活微阵列的高通量基于细胞的测定方法公开(公告)号：US20050255445A1
公开(公告)日：2005-11-17
申请号：US10516473
申请日：2003-06-03
IPC分类号： B01J19/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B30/04 , C40B60/14 , G01N33/15 , G01N33/50 , G01N33/551 , G01N33/569 , G01N33/68 , G01N37/00 , C12Q1/00
CPC分类号： C40B30/04 , B01J2219/00286 , B01J2219/00378 , B01J2219/00527 , B01J2219/00659 , B01J2219/00702 , B01J2219/00743 , C40B60/14 , G01N33/5008 , G01N33/5023 , G01N33/5026 , G01N33/551 , G01N33/56911 , G01N33/6854 , G01N2500/20
摘要： The present invention relates to methods for screening of cellular responses of cellular components comprising: (a) providing cellular components on the surface of a substrate, said substrate having immobilized thereon an array of detector molecules; (b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules on the surface of said solid substrate; (c) incubating said test compounds with said cellular components on the surface of the solid support, under conditions allowing the induction of cellular responses; (d) assaying said cellular responses; and, identifying and characterizing the cellular responses induced by said test compounds. The present invention further relates to the uses of said methods as well as microarrays and kits for carrying out said methods.
摘要翻译： 本发明涉及筛选细胞成分的细胞反应的方法，包括：（a）在基质的表面上提供细胞组分，所述底物固定有检测器分子阵列; （b）将测试化合物输送到与所述固体基底表面上的阵列检测器分子相对应的基底上的位置; （c）在允许诱导细胞反应的条件下，将所述测试化合物与固体支持物表面上的所述细胞组分一起孵育; （d）测定所述细胞反应; 以及鉴定和表征由所述测试化合物诱导的细胞应答。 本发明还涉及所述方法的用途以及用于实施所述方法的微阵列和试剂盒。
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3.发明授权Method for determining survival prognosis of patients suffering from non-small cell lung cancer (NSCLC) 有权确定患有非小细胞肺癌（NSCLC）患者生存预后的方法公开(公告)号：US08962268B2
公开(公告)日：2015-02-24
申请号：US13138849
申请日：2010-04-12
CPC分类号： G01N33/57423 , C12Q1/485
摘要： The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels in response to a kinase inhibitor and profiles in samples obtained from patients diagnosed with non-small cell lung cancer. The present invention also provides methods for predicting the response of a patient diagnosed with non-small cell lung cancer to a medicament.
摘要翻译： 本发明涉及一种确定患有非小细胞肺癌患者的生存预后的方法。 更具体地，本发明提供了通过研究响应于激酶抑制剂的磷酸化水平和从诊断为非小细胞肺癌的患者获得的样品中的分布来测量激酶活性的方法。 本发明还提供了用于预测诊断为非小细胞肺癌的患者对药物的反应的方法。
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公开(公告)号：US20120046199A1
公开(公告)日：2012-02-23
申请号：US13138847
申请日：2010-04-12
申请人： Robby Ruijtenbeek , Maria Helena Hilhorst , Arzu Umar , Johannes Albert Foekens , Johannes Wilhelmus Maria Martens
发明人： Robby Ruijtenbeek , Maria Helena Hilhorst , Arzu Umar , Johannes Albert Foekens , Johannes Wilhelmus Maria Martens
CPC分类号： G01N33/57415 , C12Q1/485 , G01N33/74 , G01N2333/723 , G01N2800/52
摘要： The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.
摘要翻译： 本发明涉及确定患有乳腺癌的患者的雌激素受体状态的方法。 本发明还旨在提供用于预测诊断为乳腺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究从诊断为乳腺癌的患者获得的样品中的磷酸化水平和特征来测量激酶活性的方法。
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公开(公告)号：US20110257025A1
公开(公告)日：2011-10-20
申请号：US12736467
申请日：2009-04-10
申请人： René Houtman , Robby Ruijtenbeek , Pieter Jacob Boender , Marinus Gerardus Johannes Van Beuningen , Maria Helena Hilhorst , Richard De Wijn
发明人： René Houtman , Robby Ruijtenbeek , Pieter Jacob Boender , Marinus Gerardus Johannes Van Beuningen , Maria Helena Hilhorst , Richard De Wijn
CPC分类号： G01N33/574 , C12Q1/485
摘要： The present invention relates to methods for identifying classification markers for tumors by monitoring the activity of protein kinases. By acquiring a phosphorylation profile of diseased and control tissue samples the method of the present invention provides classification procedures using phosphorylation patterns enabling the distinction between different types and/or sub-types of tumors. Specific classification markers for tumors can be identified enabling tumor classification, diagnosis, prognosis and/or prediction of the clinical outcome of a therapy.
摘要翻译： 本发明涉及通过监测蛋白激酶的活性来鉴定肿瘤分类标记物的方法。 通过获得患病和对照组织样品的磷酸化特征，本发明的方法提供使用能够区分不同类型和/或亚型肿瘤的磷酸化模式的分类程序。 可以鉴定肿瘤的特异性分类标记物，其能够进行治疗的临床结果的肿瘤分类，诊断，预后和/或预测。
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6.发明申请IRAK KINASE FAMILY AS NOVEL TARGET AND BIOMARKER FOR ALZHEIMER 审中-公开作为ALZHEIMER的新目标和生物标记的IRAK KINASE FAMILY公开(公告)号：US20120035076A1
公开(公告)日：2012-02-09
申请号：US13265574
申请日：2010-04-26
CPC分类号： G01N33/6896 , C07K7/08 , C12Q1/485 , G01N2500/02 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835 , G01N2800/285 , G01N2800/52
摘要： The present invention relates to methods and devices for the diagnosis or drug response prediction of neurological disorders by measuring kinase activity and studying the phosphorylation levels and profiles in samples of said patients. Furthermore the present invention relates to methods of identifying drug compounds relevant to neurological disorders by measuring kinase activity and studying phosphorylation levels. Also, the present invention relates to the use of inhibitors of the IRAK protein kinase family or a pharmaceutical composition thereof in the treatment of neurological disorders such as Alzheimer's disease.
摘要翻译： 本发明涉及用于通过测量激酶活性并研究所述患者样品中的磷酸化水平和特征来诊断或药物反应来预测神经障碍的方法和装置。 此外，本发明涉及通过测量激酶活性和研究磷酸化水平鉴定与神经疾病相关的药物化合物的方法。 此外，本发明还涉及IRAK蛋白激酶家族抑制剂或其药物组合物在治疗神经障碍如阿尔茨海默病中的用途。
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7.发明申请MEASUREMENT OF PROTEIN KINASE ACTIVITY IN CEREBROSPINAL FLUID FOR DIAGNOSIS OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS 审中-公开用于诊断神经病学和心理疾病的尿液中蛋白激酶活性的测定公开(公告)号：US20110071052A1
公开(公告)日：2011-03-24
申请号：US12736561
申请日：2009-04-24
申请人： Maria Helena Hilhorst , Richard De Wijn , Jeroen Joseph Maria Hoozemans , Saskia Maria Van Der Vies
发明人： Maria Helena Hilhorst , Richard De Wijn , Jeroen Joseph Maria Hoozemans , Saskia Maria Van Der Vies
CPC分类号： C12Q1/485 , G01N2333/91215 , G01N2800/2821
摘要： The present invention relates to the use of endogenous protein kinase activity in cerebrospinal fluid for the classification, diagnosis and prognosis of neurological and psychiatric disorders as well as for predicting and monitoring treatment effects. An array of substrates for protein kinases, immobilized on a porous matrix, is used to monitor the protein kinase activity in cerebrospinal fluid. The method of the present invention enables the early diagnosis and discrimination between neurodegenerative disorders.
摘要翻译： 本发明涉及内源性蛋白激酶活性在脑脊液中用于神经和精神疾病分类，诊断和预后以及预测和监测治疗效果的用途。 用于固定在多孔基质上的蛋白激酶底物阵列用于监测脑脊髓液中的蛋白激酶活性。 本发明的方法能够早期诊断和鉴别神经变性疾病。
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8.发明授权Method for high throughput cell-based assays using versatile living microarrays 失效使用多功能生活微阵列的高通量基于细胞的测定方法公开(公告)号：US07419778B2
公开(公告)日：2008-09-02
申请号：US10516473
申请日：2003-06-03
CPC分类号： C40B30/04 , B01J2219/00286 , B01J2219/00378 , B01J2219/00527 , B01J2219/00659 , B01J2219/00702 , B01J2219/00743 , C40B60/14 , G01N33/5008 , G01N33/5023 , G01N33/5026 , G01N33/551 , G01N33/56911 , G01N33/6854 , G01N2500/20
摘要： The present invention relates to methods for screening of cellular responses of cellular components comprising: (a) providing cellular components on the surface of a substrate, said substrate having immobilized thereon an array of detector molecules; (b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules on the surface of said solid substrate; (c) incubating said test compounds with said cellular components on the surface of the solid support, under conditions allowing the induction of cellular responses; (d) assaying said cellular responses; and, identifying and characterizing the cellular responses induced by said test compounds. The present invention further relates to the uses of said methods as well as microarrays and kits for carrying out said methods.
摘要翻译： 本发明涉及筛选细胞成分的细胞反应的方法，包括：（a）在基质的表面上提供细胞组分，所述底物固定有检测器分子阵列; （b）将测试化合物输送到与所述固体基底表面上的阵列检测器分子相对应的基底上的位置; （c）在允许诱导细胞反应的条件下，将所述测试化合物与固体支持物表面上的所述细胞组分一起孵育; （d）测定所述细胞反应; 以及鉴定和表征由所述测试化合物诱导的细胞应答。 本发明还涉及所述方法的用途以及用于实施所述方法的微阵列和试剂盒。
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9.发明授权Method for predicting the response of non-small cell lung cancer patients to targeted pharmacotherapy 有权预测非小细胞肺癌患者对靶向药物治疗反应的方法公开(公告)号：US08962267B1
公开(公告)日：2015-02-24
申请号：US13138843
申请日：2010-04-12
申请人： Richard De Wijn , Robby Ruijtenbeek , Maria Helena Hilhorst , Michael Maria Van Den Heuvel , Houke Marian Klomp
发明人： Richard De Wijn , Robby Ruijtenbeek , Maria Helena Hilhorst , Michael Maria Van Den Heuvel , Houke Marian Klomp
CPC分类号： G01N33/57423 , C12Q1/485 , G01N2333/91205 , G01N2800/52
摘要： The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non small cell lung cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in samples of said patients.
摘要翻译： 本发明涉及一种用于确定或预测诊断为非小细胞肺癌的患者对靶向药物治疗的反应的方法。 本发明还旨在提供用于预测诊断为非小细胞肺癌的患者对具体药物的反应的方法和装置。 更具体地，本发明提供了通过研究所述患者样品中的药物的磷酸化水平及其特征和抑制来测量激酶活性的方法。
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10.发明申请METHOD FOR DETERMINING SURIVIVAL PROGNOSIS OF PATIENTS SUFFERING FROM NON-SMALL CELL LUNG CANCER (NSCLC) 有权确定非小细胞肺癌（NSCLC）患者生存预后的方法公开(公告)号：US20130017963A1
公开(公告)日：2013-01-17
申请号：US13138849
申请日：2010-04-12
IPC分类号： C40B30/04
CPC分类号： G01N33/57423 , C12Q1/485
摘要： The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels in response to a kinase inhibitor and profiles in samples obtained from patients diagnosed with non-small cell lung cancer. The present invention also provides methods for predicting the response of a patient diagnosed with non-small cell lung cancer to a medicament.
摘要翻译： 本发明涉及一种确定患有非小细胞肺癌患者的生存预后的方法。 更具体地，本发明提供了通过研究响应于激酶抑制剂的磷酸化水平和从诊断为非小细胞肺癌的患者获得的样品中的分布来测量激酶活性的方法。 本发明还提供了用于预测诊断为非小细胞肺癌的患者对药物的反应的方法。
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