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公开(公告)号：US10354207B2
公开(公告)日：2019-07-16
申请号：US13461507
申请日：2012-05-01
Applicant: Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
Inventor： Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
Abstract: Systems and methods for optimization of real time production operations. In one embodiment, a moving time horizon based parametric model provides fast predictions for production optimization in a short-term framework. In another embodiment, multiple technologies are selected in connection with asset performance workflows that are uniquely implemented in a multi-phase approach.
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公开(公告)号：US08452543B2
公开(公告)日：2013-05-28
申请号：US11992633
申请日：2006-09-19
Applicant: Vincent H. Tam , Michael Nikolaou
Inventor： Vincent H. Tam , Michael Nikolaou
CPC classification number: C40B30/02 , G06F19/704 , G06F19/706 , Y02A90/26
Abstract: Provided herein are methods and computer-implemented systems for using computer simulations to predict likelihood of a cell population associated with a pathophysiological condition acquiring resistance to a therapeutic agent, to screen for therapeutic agents effective to suppress acquisition of resistance within a cell population and to treat the pathophysiological conditions associated therewith. The computer simulation comprises at least an input/out system and a mathematical model, including operably linked equations, parameter values and constant values, of growth response over a period of time of a cell population in contact with an therapeutic agent. Also provide is a method for determining a best-fit mathematical model of adaptation of a microbial population to a therapeutic agent over time and using the model to simulate microbial population behavior to a therapeutic agent.
Abstract translation: 本文提供的方法和计算机实现的系统用于使用计算机模拟来预测与获得对治疗剂的抗性的病理生理条件相关联的细胞群体的可能性，筛选有效抑制细胞群体内的抗性获得并治疗的治疗剂 与之相关的病理生理条件。 计算机模拟至少包括输入/输出系统和数学模型，包括在与治疗剂接触的细胞群体的时间段内的生长响应的可操作地连接的方程，参数值和恒定值。 还提供了一种用于确定微生物群体随时间推移向治疗剂适应的最佳拟合数学模型的方法，并且使用该模型来模拟对治疗剂的微生物群体行为。
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公开(公告)号：US08396826B2
公开(公告)日：2013-03-12
申请号：US12337437
申请日：2008-12-17
Applicant: Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
Inventor： Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
Abstract: Systems and methods for optimization of real time production operations. In one embodiment, a moving time horizon based parametric model provides fast predictions for production optimization in a short-term framework. In another embodiment, multiple technologies are selected in connection with asset performance workflows that are uniquely implemented in a multi-phase approach.
Abstract translation: 优化实时生产操作的系统和方法。 在一个实施例中，基于移动时间范围的参数模型在短期框架中为生产优化提供快速预测。 在另一个实施例中，结合在多阶段方法中唯一实现的资产性能工作流来选择多种技术。
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公开(公告)号：US20100292964A1
公开(公告)日：2010-11-18
申请号：US11992633
申请日：2006-09-19
Applicant: Vincent H Tam , Michael Nikolaou
Inventor： Vincent H Tam , Michael Nikolaou
CPC classification number: C40B30/02 , G06F19/704 , G06F19/706 , Y02A90/26
Abstract: Provided herein are methods and computer-implemented systems for using computer simulations to predict likelihood of a cell population associated with a pathophysiological condition acquiring resistance to a therapeutic agent, to screen for therapeutic agents effective to suppress acquisition of resistance within a cell population and to treat the pathophysiological conditions associated therewith. The computer simulation comprises at least an input/out system and a mathematical model, including operably linked equations, parameter values and constant values, of growth response over a period of tune of a cell population in contact with an therapeutic agent.
Abstract translation: 本文提供的方法和计算机实现的系统用于使用计算机模拟来预测与获得对治疗剂的抗性的病理生理条件相关联的细胞群体的可能性，筛选有效抑制细胞群体内的抗性获得并治疗的治疗剂 与之相关的病理生理条件。 计算机模拟至少包括输入/输出系统和数学模型，包括在与治疗剂接触的细胞群体的调节期间的生长响应的可操作连接的方程，参数值和恒定值。
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5.发明授权公开(公告)号：US06834233B2
公开(公告)日：2004-12-21
申请号：US10071880
申请日：2002-02-08
Applicant: Michael J. Economides , Wolfgang F. J. Deeg , Peter Valko , Michael Nikolaou , Sathish Sankaran
Inventor： Michael J. Economides , Wolfgang F. J. Deeg , Peter Valko , Michael Nikolaou , Sathish Sankaran
IPC: E21B4326
CPC classification number: E21B49/006
Abstract: A system and method for the measurement of the stresses and pressure perturbations surrounding a well, and a system for computing the optimum location for initiating a hydraulic stress fracture. The technique includes using sensors attached to the wellbore casing connected to a data analyzer. The analyzer is capable of analyzing the stresses on the well system. Using an inverse problem framework for an open-hole situation, the far field stresses and well departure angle are determined once the pressure perturbations and stresses are measured on the wellbore casing. The number of wellbore measurements needed for the inverse problem solution also is determined. The technique is also capable of determining the optimal location for inducing a hydraulic fracture, the effect of noisy measurements on the accuracy of the results, and assessing the quality of a bond between a casing and a sealant.
Abstract translation: 用于测量井周围的应力和压力扰动的系统和方法，以及用于计算用于启动液压应力断裂的最佳位置的系统。 该技术包括使用附接到连接到数据分析仪的井眼套管的传感器。 分析仪能够分析井系统的应力。 使用反问题框架进行露天情况，一旦在井眼套管上测量压力扰动和应力，则确定远场应力和井出射角。 确定逆问题解决方案所需的井筒测量数量。 该技术还能够确定用于引起水力压裂的最佳位置，噪声测量对结果精度的影响，以及评估套管和密封剂之间的粘结质量。
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Patent Agency Ranking
公开(公告)号：US20140011762A1
公开(公告)日：2014-01-09
申请号：US13899876
申请日：2013-05-22
Applicant: Vincent H. Tam , Michael Nikolaou
Inventor： Vincent H. Tam , Michael Nikolaou
CPC classification number: G16B5/00 , C12Q1/025 , G01N2500/10 , G01N2800/44 , Y02A90/26
Abstract: Provided herein are methods and computer-implemented systems for using computer simulations to predict likelihood of a cell population associated with a pathophysiological condition acquiring resistance to a therapeutic agent, to screen for therapeutic agents effective to suppress acquisition of resistance within a cell population and to treat the pathophysiological conditions associated therewith. The computer simulation comprises at least an input/out system and a mathematical model, including operably linked equations, parameter values and constant values, of growth response over a period of time of a cell population in contact with an therapeutic agent. Also provide is a method for determining a best-fit mathematical model of adaptation of a microbial population to a therapeutic agent over time and using the model to simulate microbial population behavior to a therapeutic agent.
Abstract translation: 本文提供的方法和计算机实现的系统用于使用计算机模拟来预测与获得对治疗剂的抗性的病理生理条件相关联的细胞群体的可能性，筛选有效抑制细胞群体内的抗性获得并治疗的治疗剂 与之相关的病理生理条件。 计算机模拟至少包括输入/输出系统和数学模型，包括在与治疗剂接触的细胞群体的时间段内的生长响应的可操作地连接的方程，参数值和恒定值。 还提供了一种用于确定微生物群体随时间推移向治疗剂适应的最佳拟合数学模型的方法，并且使用该模型来模拟对治疗剂的微生物群体行为。
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公开(公告)号：US20090157590A1
公开(公告)日：2009-06-18
申请号：US12337437
申请日：2008-12-17
Applicant: Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
Inventor： Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
Abstract: Systems and methods for optimization of real time production operations. In one embodiment, a moving time horizon based parametric model provides fast predictions for production optimization in a short-term framework. In another embodiment, multiple technologies are selected in connection with asset performance workflows that are uniquely implemented in a multi-phase approach.
Abstract translation: 优化实时生产操作的系统和方法。 在一个实施例中，基于移动时间范围的参数模型在短期框架中为生产优化提供快速预测。 在另一个实施例中，结合在多阶段方法中唯一实现的资产性能工作流来选择多种技术。
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公开(公告)号：US07006918B2
公开(公告)日：2006-02-28
申请号：US10986262
申请日：2004-11-10
Applicant: Michael J. Economides , Wolfgang F. J. Deeg , Peter Valko , Michael Nikolaou , Sathish Sankaran
Inventor： Michael J. Economides , Wolfgang F. J. Deeg , Peter Valko , Michael Nikolaou , Sathish Sankaran
IPC: G06F19/00
CPC classification number: E21B49/006
Abstract: A method for the measurement of the stresses and pressure perturbations surrounding a well, and a system for computing the optimum location for initiating a hydraulic stress fracture. The technique includes using sensors attached to the wellbore casing connected to a data analyzer. The analyzer is capable of analyzing the stresses on the well system. Using an inverse problem framework for an open-hole situation, the far field stresses and well departure angle are determined once the pressure perturbations and stresses are measured on the wellbore casing. The number of wellbore measurements needed for the inverse problem solution also is determined. The technique is also capable of determining the optimal location for inducing a hydraulic fracture, the effect of noisy measurements on the accuracy of the results, and assessing the quality of a bond between a casing and a sealant.
Abstract translation: 用于测量井周围的应力和压力扰动的方法，以及用于计算用于启动液压应力断裂的最佳位置的系统。 该技术包括使用附接到连接到数据分析仪的井眼套管的传感器。 分析仪能够分析井系统的应力。 使用反问题框架进行露天情况，一旦在井眼套管上测量压力扰动和应力，则确定远场应力和井出射角。 确定逆问题解决方案所需的井筒测量数量。 该技术还能够确定用于引起水力压裂的最佳位置，噪声测量对结果精度的影响，以及评估套管和密封剂之间的粘结质量。
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9.发明申请公开(公告)号：US20120215502A1
公开(公告)日：2012-08-23
申请号：US13461507
申请日：2012-05-01
Applicant: Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
Inventor： Gerardo Mijares , Alejandro Garcia , Sathish Sankaran , Jose Rodriguez , Luigi Saputelli , Ankur Awasthi , Michael Nikolaou
IPC: G06F17/10
Abstract: Systems and methods for optimization of real time production operations. In one embodiment, a moving time horizon based parametric model provides fast predictions for production optimization in a short-term framework. In another embodiment, multiple technologies are selected in connection with asset performance workflows that are uniquely implemented in a multi-phase approach.
Abstract translation: 优化实时生产操作的系统和方法。 在一个实施例中，基于移动时间范围的参数模型在短期框架中为生产优化提供快速预测。 在另一个实施例中，结合在多阶段方法中唯一实现的资产性能工作流来选择多种技术。
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公开(公告)号：US20050234648A1
公开(公告)日：2005-10-20
申请号：US10986262
申请日：2004-11-10
Applicant: Michael Economides , Wolfgang Deeg , Peter Valko , Michael Nikolaou , Sathish Sankaran
Inventor： Michael Economides , Wolfgang Deeg , Peter Valko , Michael Nikolaou , Sathish Sankaran
CPC classification number: E21B49/006
Abstract: A method for the measurement of the stresses and pressure perturbations surrounding a well, and a system for computing the optimum location for initiating a hydraulic stress fracture. The technique includes using sensors attached to the wellbore casing connected to a data analyzer. The analyzer is capable of analyzing the stresses on the well system. Using an inverse problem framework for an open-hole situation, the far field stresses and well departure angle are determined once the pressure perturbations and stresses are measured on the wellbore casing. The number of wellbore measurements needed for the inverse problem solution also is determined. The technique is also capable of determining the optimal location for inducing a hydraulic fracture, the effect of noisy measurements on the accuracy of the results, and assessing the quality of a bond between a casing and a sealant.
Abstract translation: 用于测量井周围的应力和压力扰动的方法，以及用于计算用于启动液压应力断裂的最佳位置的系统。 该技术包括使用附接到连接到数据分析仪的井眼套管的传感器。 分析仪能够分析井系统的应力。 使用反问题框架进行露天情况，一旦在井眼套管上测量压力扰动和应力，则确定远场应力和井出射角。 确定逆问题解决方案所需的井筒测量数量。 该技术还能够确定用于引起水力压裂的最佳位置，噪声测量对结果精度的影响，以及评估套管和密封剂之间的粘结质量。
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