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公开(公告)号：US5920399A
公开(公告)日：1999-07-06
申请号：US820298
申请日：1997-03-18
申请人： David R. Sandison , Mark R. Platzbecker , Timothy D. Vargo , Randal R. Lockhart , Michael R. Descour , Rebecca Richards-Kortum
发明人： David R. Sandison , Mark R. Platzbecker , Timothy D. Vargo , Randal R. Lockhart , Michael R. Descour , Rebecca Richards-Kortum
CPC分类号： A61B5/0084 , A61B5/0086 , A61B5/4331 , G01J3/2823
摘要： A multispectral imaging method and apparatus adapted for use in determining material properties, especially properties characteristic of abnormal non-dermal cells. A target is illuminated with a narrow band light beam. The target expresses light in response to the excitation. The expressed light is collected and the target's response at specific response wavelengths to specific excitation wavelengths is measured. From the measured multispectral response the target's properties can be determined. A sealed, remote probe and robust components can be used for cervical imaging
摘要翻译： 适用于确定材料性质，特别是异常非真皮细胞性质特征的多光谱成像方法和装置。 用窄带光束照射目标。 目标响应激发表达光。 收集表达的光，并测量目标在特定响应波长对特定激发波长的响应。 从测量的多光谱响应可以确定目标的属性。 密封的远程探头和坚固的部件可用于颈部成像
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公开(公告)号：US07184610B2
公开(公告)日：2007-02-27
申请号：US10637486
申请日：2003-08-11
CPC分类号： G02B21/002 , G02B21/367
摘要： An array of microscopes and a method of imaging an object with the array of microscopes. The array includes a plurality of optical elements being individually disposed with respect to a corresponding image plane and configured to image respective sections of an object, and includes a plurality of image sensors corresponding to respective optical elements and configured to capture corresponding representations of the respective sections of the object. The method includes imaging respective sections of an object with a plurality of optical elements and capturing corresponding representations of sections of the object from a plurality of image sensors.
摘要翻译： 一系列显微镜和使用显微镜阵列成像物体的方法。 该阵列包括多个光学元件，其相对于对应的图像平面被单独设置，并且被配置为对对象的各个部分进行成像，并且包括与各个光学元件对应的多个图像传感器，并且被配置为捕获各个部分的相应表示 的对象。 该方法包括用多个光学元件成像对象的各个部分，并从多个图像传感器捕获对象的部分的对应表示。
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公开(公告)号：US06370422B1
公开(公告)日：2002-04-09
申请号：US09272719
申请日：1999-03-19
IPC分类号： A61B600
CPC分类号： A61B5/0084 , A61B5/0068 , G02B23/2453 , G02B23/26
摘要： An apparatus and methods for fiber optic confocal imaging systems. A plurality of fibers are in communication with a scan system that controllably deflects incident radiation into the fibers in a raster pattern. An index matching agent reduces specular reflections from the fibers.
摘要翻译： 一种用于光纤共聚焦成像系统的装置和方法。 多个光纤与扫描系统通信，扫描系统以光栅图案可控地将入射的辐射偏转到光纤中。 指数匹配剂降低了纤维的镜面反射。
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公开(公告)号：US07864380B2
公开(公告)日：2011-01-04
申请号：US11711283
申请日：2007-02-27
申请人： Michael R. Descour , Artur G. Olszak , Andrew Lowe
发明人： Michael R. Descour , Artur G. Olszak , Andrew Lowe
CPC分类号： G02B21/34 , G01N2001/282 , G01N2035/00772
摘要： In a scanning microscope, slides are fed automatically from a magazine to the imaging system. Each slide is labeled in some fashion with information for selecting the appropriate modality of operation of the scanner for that slide and the modality is implemented automatically. The information is preferably tied to and defined by a laboratory information system (LIS). For example, the instructions may regard the type of microscopy (i.e., trans- or epi-illumination), multi-spectral imaging with particular spectral bands combined with a particular set of z-positions, alternative filters, settings for the numerical aperture of the condenser, alternative detector operation for different resolutions, and alternative post-scan analyses of the data, as deemed optimal for the scan. The label may also contain the slide's identity, a pathologist's name, desired post-scan handling protocol, etc. The preferred array microscope to carry out the invention is also described.
摘要翻译： 在扫描显微镜中，幻灯片自动从一个暗盒进给成像系统。 每个幻灯片都以某种方式被标记为具有用于选择用于该幻灯片的扫描器的适当操作模式的信息，并且该模式被自动实现。 该信息最好与实验室信息系统（LIS）相关联并由其定义。 例如，说明书可以将显微镜的类型（即透射或表面照明），具有与特定z轴位置组合的特定光谱带的多光谱成像，替代滤光片，数值孔径的设置 冷凝器，不同分辨率的替代检测器操作，以及数据的替代扫描后分析，被认为是扫描的最佳选择。 标签还可以包含幻灯片的身份，病理学家的名字，期望的扫描后处理协议等。还描述了实现本发明的优选阵列显微镜。
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公开(公告)号：US07116437B2
公开(公告)日：2006-10-03
申请号：US10243648
申请日：2002-09-16
IPC分类号： H04N1/40
CPC分类号： G02B27/0018 , G02B21/002
摘要： A multi-axis imaging system and method wherein a plurality of optical elements are arranged to produce in image space thereof respective images of respective regions in object space thereof, and a plurality of image sensing elements corresponding to respective optical elements are disposed in image space of the image sensing elements to capture images of the respective regions. At least one baffle is positioned along an optical pathway of at least one of the optical elements to block light from outside the field of view of the one of the optical elements from reaching a corresponding image sensing element.
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公开(公告)号：US07130115B2
公开(公告)日：2006-10-31
申请号：US10666990
申请日：2003-09-19
申请人： Artur G. Olszak , Chen Liang , Michael R. Descour
发明人： Artur G. Olszak , Chen Liang , Michael R. Descour
IPC分类号： G02B21/18
CPC分类号： G02B21/002 , G02B21/367
摘要： A multi-mode scanning imaging system. The system includes a plurality of sets of optical elements and a scanning mechanism. Each set is disposed with respect to a corresponding image plane and configured to image respective portions of an object. A scanning mechanism produces relative translation between the sets and the object so as to scan the object. Sets of image sensors corresponding to the sets of optical elements are adapted to capture image data representative of the respective portions of the object. A mode implementation system coordinates the image data according to one or more desired modes of operation of the imaging system.
摘要翻译： 多模扫描成像系统。 该系统包括多组光学元件和扫描机构。 每个组相对于对应的图像平面设置并且被配置为对对象的各个部分进行成像。 扫描机制产生组和对象之间的相对平移，以扫描对象。 对应于这些光学元件组的图像传感器的组适于捕获表示对象的各个部分的图像数据。 模式实现系统根据成像系统的一个或多个期望的操作模式来协调图像数据。
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公开(公告)号：US07061584B2
公开(公告)日：2006-06-13
申请号：US10666330
申请日：2003-09-19
CPC分类号： G02B3/0056 , G02B3/0062 , G02B21/002 , G02B21/367 , G03F7/7005 , G03F7/70275 , G03F7/70291 , G03F7/70391
摘要： A multi-axis projection imaging system. Such a system includes a plurality of objectives defining respective object fields of view and corresponding image fields of view. An object is adapted for controllably illuminating the object fields of view with light that varies spatially in one or more selected characteristics, for creating respective images within the image fields of view.
摘要翻译： 多轴投影成像系统。 这样的系统包括限定相应的对象视场和对应的图像视场的多个目标。 物体适于用在一个或多个所选特征中空间变化的光来可控地照亮物体视野，以在图像视场内创建各自的图像。
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公开(公告)号：US07755841B2
公开(公告)日：2010-07-13
申请号：US12011818
申请日：2008-01-30
CPC分类号： B29D11/00028 , B29D11/00807 , G02B3/0012 , G02B3/0056 , G02B3/14 , G02B21/002 , G02B21/02
摘要： A liquid lens includes a segmented electrode that allows the simultaneous application of different potentials across the lens's meniscus to obtain a predetermined aberration correction condition and to adjust focal length as necessary to conform to the topography of the object being scanned. The lens also includes a gas plenum interfacing with one of the liquids of the lens to allow for volume changes in the lens cell due to temperature variations. This combination of features produces a liquid-lens cell capable of maintaining substantially constant transverse magnification and diffraction-limited image quality over a useful range of focal length. As such, the lens is particularly suitable for incorporation in an array of micro-objectives used in a scanning microscope.
摘要翻译： 液体透镜包括分段电极，其允许跨透镜的弯月面同时施加不同电位以获得预定的像差校正条件，并且根据需要调整焦距以符合被扫描物体的形貌。 透镜还包括与透镜的液体之一接口的气体增压室，以允许由于温度变化导致的透镜单元的体积变化。 特征的这种组合产生能够在有效的焦距范围内保持基本恒定的横向放大率和衍射受限图像质量的液体透镜单元。 因此，镜片特别适合于并入在扫描显微镜中使用的微观物镜的阵列中。
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公开(公告)号：US20080297911A1
公开(公告)日：2008-12-04
申请号：US12011818
申请日：2008-01-30
CPC分类号： B29D11/00028 , B29D11/00807 , G02B3/0012 , G02B3/0056 , G02B3/14 , G02B21/002 , G02B21/02
摘要： A liquid lens includes a segmented electrode that allows the simultaneous application of different potentials across the lens's meniscus to obtain a predetermined aberration correction condition and to adjust focal length as necessary to conform to the topography of the object being scanned. The lens also includes a gas plenum interfacing with one of the liquids of the lens to allow for volume changes in the lens cell due to temperature variations. This combination of features produces a liquid-lens cell capable of maintaining substantially constant transverse magnification and diffraction-limited image quality over a useful range of focal length. As such, the lens is particularly suitable for incorporation in an array of micro-objectives used in a scanning microscope.
摘要翻译： 液体透镜包括分段电极，其允许跨透镜的弯月面同时施加不同电位以获得预定的像差校正条件，并且根据需要调整焦距以符合被扫描物体的形貌。 透镜还包括与透镜的液体之一接口的气体增压室，以允许由于温度变化导致的透镜单元的体积变化。 特征的这种组合产生能够在有效的焦距范围内保持基本恒定的横向放大率和衍射受限图像质量的液体透镜单元。 因此，镜片特别适合于并入在扫描显微镜中使用的微观物镜的阵列中。
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公开(公告)号：US06504943B1
公开(公告)日：2003-01-07
申请号：US09345604
申请日：1999-06-29
申请人： William C. Sweatt , Stephen M. Gentry , Clinton A. Boye , Carter L. Grotbeck , Brian R. Stallard , Michael R. Descour
发明人： William C. Sweatt , Stephen M. Gentry , Clinton A. Boye , Carter L. Grotbeck , Brian R. Stallard , Michael R. Descour
IPC分类号： G06K900
CPC分类号： G06T5/50 , G02B27/1086 , G02B27/123 , G02B27/126 , G02B27/145 , G02B27/28 , G02B27/4205 , G02B27/4294 , G06K9/0063 , G06T7/0008 , G06T2207/10152 , G06T2207/30108
摘要： A programmable optical filter for use in multispectral and hyperspectral imaging. The filter splits the light collected by an optical telescope into two channels for each of the pixels in a row in a scanned image, one channel to handle the positive elements of a spectral basis filter and one for the negative elements of the spectral basis filter. Each channel for each pixel disperses its light into n spectral bins, with the light in each bin being attenuated in accordance with the value of the associated positive or negative element of the spectral basis vector. The spectral basis vector is constructed so that its positive elements emphasize the presence of a target and its negative elements emphasize the presence of the constituents of the background of the imaged scene. The attenuated light in the channels is re-imaged onto separate detectors for each pixel and then the signals from the detectors are combined to give an indication of the presence or not of the target in each pixel of the scanned scene. This system provides for a very efficient optical determination of the presence of the target, as opposed to the very data intensive data manipulations that are required in conventional hyperspectral imaging systems.
摘要翻译： 一种用于多光谱和高光谱成像的可编程滤光片。 滤光器将由光学望远镜收集的光分成扫描图像中的一行中的每个像素的两个通道，一个通道用于处理光谱基滤波器的正元素，一个用于光谱基滤波器的负元件。 每个像素的每个通道将其光分散到n个光谱箱中，每个存储体中的光根据光谱基础矢量的相关联的正或负元素的值衰减。 构建光谱基矢量，使其正元素强调目标的存在，其负元素强调成像场景的背景的成分的存在。 通道中的衰减光被重新成像到用于每个像素的分离的检测器上，然后来自检测器的信号被组合以给出在扫描场景的每个像素中存在或不存在目标的指示。 与传统的高光谱成像系统中所需的非常数据密集的数据操作相反，该系统提供了对靶的存在的非常有效的光学确定。
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