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公开(公告)号：US20090306054A1
公开(公告)日：2009-12-10
申请号：US12299885
申请日：2007-05-16
Applicant: Zhenhong R. Cai , Salman Y. Jabri , Haolun Jin , Rachel A. Lansdown , Samuel E. Metobo , Michael R. Mish , Richard M. Pastor
Inventor： Zhenhong R. Cai , Salman Y. Jabri , Haolun Jin , Rachel A. Lansdown , Samuel E. Metobo , Michael R. Mish , Richard M. Pastor
IPC: A61K31/437 , C07D471/04 , A61K31/551 , A61K31/5377 , A61P31/18
CPC classification number: C07D471/04
Abstract: Tricyclic compounds of formulae I-III, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
Abstract translation: 公开了式I-III的三环化合物，其受保护的中间体以及用于抑制HIV整合酶的方法。
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2.发明授权公开(公告)号：US08877733B2
公开(公告)日：2014-11-04
申请号：US13447017
申请日：2012-04-13
Applicant: Aesop Cho , Choung U. Kim , Thorsten A. Kirschberg , Michael R. Mish , Neil Squires
Inventor： Aesop Cho , Choung U. Kim , Thorsten A. Kirschberg , Michael R. Mish , Neil Squires
IPC: A61K31/70 , C07H19/06 , A61K31/196 , C07H19/073 , A61K31/7068 , C07H19/067 , A61K31/7072 , C07H19/09 , C07H19/10 , A61K45/06 , A61K31/351 , A61K31/245 , C07H19/11 , A61K38/21 , A61K31/13
CPC classification number: C07H19/06 , A61K31/13 , A61K31/196 , A61K31/245 , A61K31/351 , A61K31/7068 , A61K31/7072 , A61K38/21 , A61K45/06 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , A61K2300/00
Abstract: Provided are compounds of Formula I: nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
Abstract translation: 提供式I化合物：核苷，磷酸核苷及其前体药物，其中R6是CN，乙烯基，2-卤代乙烯-1-基或（C2-C8） - 炔炔-1-基。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染。
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公开(公告)号：US20080076740A1
公开(公告)日：2008-03-27
申请号：US11494818
申请日：2006-07-27
Applicant: Zhenhong R. Cai , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Samuel E. Metobo , Michael R. Mish , Richard M. Pastor
Inventor： Zhenhong R. Cai , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Samuel E. Metobo , Michael R. Mish , Richard M. Pastor
IPC: A61K31/675 , A61P31/18
CPC classification number: A61K47/548
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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4.发明申请公开(公告)号：US20120263678A1
公开(公告)日：2012-10-18
申请号：US13447017
申请日：2012-04-13
Applicant: Aesop Cho , Choung U. Kim , Thorsten A. Kirschberg , Michael R. Mish , Neil Squires
Inventor： Aesop Cho , Choung U. Kim , Thorsten A. Kirschberg , Michael R. Mish , Neil Squires
IPC: A61K31/7072 , A61K31/7068 , C07H19/06 , A61K38/21 , A61P31/14 , C07H19/073 , C07H19/067 , C07H19/10
CPC classification number: C07H19/06 , A61K31/13 , A61K31/196 , A61K31/245 , A61K31/351 , A61K31/7068 , A61K31/7072 , A61K38/21 , A61K45/06 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , A61K2300/00
Abstract: Provided are compounds of Formula I: nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
Abstract translation: 提供式I化合物：核苷，磷酸核苷及其前体药物，其中R6是CN，乙烯基，2-卤代乙烯-1-基或（C2-C8） - 炔炔-1-基。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染。
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Patent Agency Ranking
公开(公告)号：US08008287B2
公开(公告)日：2011-08-30
申请号：US11804041
申请日：2007-05-16
Applicant: Zhenhong R. Cai , Salman Y. Jabri , Haolun Jin , Rachael A. Lansdown , Samuel E. Metobo , Michael R. Mish , Richard M. Pastor
Inventor： Zhenhong R. Cai , Salman Y. Jabri , Haolun Jin , Rachael A. Lansdown , Samuel E. Metobo , Michael R. Mish , Richard M. Pastor
IPC: A61K31/54 , A01N43/58 , A01N43/60 , C07D471/00 , C07D487/00 , C07D401/00
CPC classification number: C07D471/04
Abstract: Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
Abstract translation: 公开了三环化合物，其受保护的中间体以及用于抑制HIV整合酶的方法。
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公开(公告)号：US20090291921A1
公开(公告)日：2009-11-26
申请号：US12274107
申请日：2008-11-19
Applicant: Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish
Inventor： Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish
IPC: A61K31/675 , A61K31/54 , A61K31/497 , A61K31/4745 , C07F9/28 , C07D471/00
CPC classification number: C07D487/02
Abstract: Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
Abstract translation: 公开了三环化合物，其受保护的中间体以及用于抑制HIV整合酶的方法。
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公开(公告)号：US07998950B2
公开(公告)日：2011-08-16
申请号：US12509250
申请日：2009-07-24
Applicant: Evangelos Aktoudianakis , Azim Alan Celebi , Zhimin Du , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish , Barton W. Phillips , Joseph H. Saugier , Zheng-Yu Yang , Catalin Sebastian Zonte
Inventor： Evangelos Aktoudianakis , Azim Alan Celebi , Zhimin Du , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish , Barton W. Phillips , Joseph H. Saugier , Zheng-Yu Yang , Catalin Sebastian Zonte
IPC: A61K31/55 , A61K31/5365 , A61K31/495 , A61K31/436 , C07D265/28 , C07D471/12 , C07D498/12
CPC classification number: C07D498/16 , C07D471/16
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20100022508A1
公开(公告)日：2010-01-28
申请号：US12509250
申请日：2009-07-24
Applicant: Evangelos Aktoudianakis , Azim Alan Celebi , Zhimin Du , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish , Barton W. Phillips , Joseph H. Saugier , Zheng-Yu Yang , Catalin Sebastian Zonte
Inventor： Evangelos Aktoudianakis , Azim Alan Celebi , Zhimin Du , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish , Barton W. Phillips , Joseph H. Saugier , Zheng-Yu Yang , Catalin Sebastian Zonte
IPC: A61K31/553 , A61K31/5383 , A61K31/4985 , A61K31/4375 , A61P31/18 , C07D498/16 , C07D487/16 , C07D471/16
CPC classification number: C07D498/16 , C07D471/16
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20120053148A1
公开(公告)日：2012-03-01
申请号：US13157127
申请日：2011-06-09
Applicant: Zhenhong R. Cai , Zhimin Du , Mingzhe Ji , Haolun Jin , Choung U. Kim , Michael R. Mish , Barton W. Phillips , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu , Catalin Sebastian Zonte
Inventor： Zhenhong R. Cai , Zhimin Du , Mingzhe Ji , Haolun Jin , Choung U. Kim , Michael R. Mish , Barton W. Phillips , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu , Catalin Sebastian Zonte
IPC: A61K31/675 , C07D417/12 , A61P31/14 , A61K31/541 , C07D401/14 , C07D401/12 , A61K31/4709
CPC classification number: C07D401/10 , A61K45/06 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/65583
Abstract: The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
Abstract translation: 本申请包括HCV的新型抑制剂，含有这些化合物的组合物，包括施用这些化合物的治疗方法。
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