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![4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use](/abs-image/US/2017/04/18/US09624238B2/abs.jpg.150x150.jpg)
1.发明授权公开(公告)号：US09624238B2
公开(公告)日：2017-04-18
申请号：US14284106
申请日：2014-05-21
申请人： Joseph Barbosa , Kenneth Gordon Carson , Michael Walter Gardyan , Jason Patrick Healy , Qiang Han , Ross Mabon , Praveen Pabba , James Tarver, Jr. , Kristen M. Terranova , Ashok Tunoori , Xiaolian Xu
发明人： Joseph Barbosa , Kenneth Gordon Carson , Michael Walter Gardyan , Jason Patrick Healy , Qiang Han , Ross Mabon , Praveen Pabba , James Tarver, Jr. , Kristen M. Terranova , Ashok Tunoori , Xiaolian Xu
IPC分类号： C07D333/52 , C07D495/04
CPC分类号： C07D495/04 , C07D333/52
摘要： Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
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公开(公告)号：US20140288071A1
公开(公告)日：2014-09-25
申请号：US14300281
申请日：2014-06-10
申请人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Wei HE , Victoria LOMBARDO , Praveen PABBA , James TARVER, JR.
发明人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Wei HE , Victoria LOMBARDO , Praveen PABBA , James TARVER, JR.
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.
摘要翻译： 公开了用于治疗，管理和预防影响骨骼的疾病和病症的化合物。 特殊的化合物是Notum果胶乙酰酯酶的有效抑制剂，具有下式：其中E，G，Y，Z，R 1，R 2和R 3在本文中定义。
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![4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE](/abs-image/US/2014/09/11/US20140256784A1/abs.jpg.150x150.jpg)
3.发明申请4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE 有权4H-THIENO [3,2-C]基于琥珀酸的抑制剂及其使用方法公开(公告)号：US20140256784A1
公开(公告)日：2014-09-11
申请号：US14284106
申请日：2014-05-21
申请人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
发明人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , C07D333/52
摘要： Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
摘要翻译： 本发明描述了可用于抑制Notum果胶乙酰酯酶的化合物，以及包含它们的组合物及其用于治疗影响骨骼的疾病和障碍的方法。
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![4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE](/abs-image/US/2012/11/29/US20120302562A1/abs.jpg.150x150.jpg)
4.发明申请4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE 审中-公开4H-THIENO [3,2-C]基于琥珀酸的抑制剂及其使用方法公开(公告)号：US20120302562A1
公开(公告)日：2012-11-29
申请号：US13478529
申请日：2012-05-23
申请人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
发明人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
IPC分类号： A61K31/381 , C07D333/74 , A61K31/382 , C07D413/12 , A61K31/5377 , A61P19/10 , A61K31/41 , A61K31/4178 , A61K31/422 , A61K31/4535 , A61K31/4025 , A61K31/4436 , C07D495/04 , C07D409/12
CPC分类号： C07D495/04 , C07D333/52
摘要： Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
摘要翻译： 本发明描述了可用于抑制Notum果胶乙酰酯酶的化合物，以及包含它们的组合物及其用于治疗影响骨骼的疾病和障碍的方法。
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公开(公告)号：US20120065200A1
公开(公告)日：2012-03-15
申请号：US13231653
申请日：2011-09-13
申请人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Wei HE , Victoria LOMBARDO , Praveen PABBA , James TARVER, JR.
发明人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Wei HE , Victoria LOMBARDO , Praveen PABBA , James TARVER, JR.
IPC分类号： A61K31/519 , A61P19/00 , A61K31/5377 , C07D495/04 , C07D495/14
CPC分类号： C07D495/04
摘要： Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.
摘要翻译： 公开了用于治疗，管理和预防影响骨骼的疾病和病症的化合物。 特殊的化合物是Notum果胶乙酰酯酶的有效抑制剂，具有下式：其中E，G，Y，Z，R 1，R 2和R 3在本文中定义。
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