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1.
公开(公告)号:US09624238B2
公开(公告)日:2017-04-18
申请号:US14284106
申请日:2014-05-21
申请人: Joseph Barbosa , Kenneth Gordon Carson , Michael Walter Gardyan , Jason Patrick Healy , Qiang Han , Ross Mabon , Praveen Pabba , James Tarver, Jr. , Kristen M. Terranova , Ashok Tunoori , Xiaolian Xu
发明人: Joseph Barbosa , Kenneth Gordon Carson , Michael Walter Gardyan , Jason Patrick Healy , Qiang Han , Ross Mabon , Praveen Pabba , James Tarver, Jr. , Kristen M. Terranova , Ashok Tunoori , Xiaolian Xu
IPC分类号: C07D333/52 , C07D495/04
CPC分类号: C07D495/04 , C07D333/52
摘要: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
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公开(公告)号:US07723345B2
公开(公告)日:2010-05-25
申请号:US11638677
申请日:2006-12-12
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/505 , C07D239/02
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
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公开(公告)号:US20100087433A1
公开(公告)日:2010-04-08
申请号:US12571912
申请日:2009-10-01
申请人: Catherine Bomont , Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang
发明人: Catherine Bomont , Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang
IPC分类号: A61K31/5377 , A61K31/4418 , A61K31/444 , A61P25/00
CPC分类号: C07D401/06 , C07D213/74 , C07D213/89 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/14 , C07D417/14
摘要: Compounds, compositions and methods of treating serotonin-mediated diseases and disorders are disclosed.
摘要翻译: 公开了治疗5-羟色胺介导的疾病和病症的化合物,组合物和方法。
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公开(公告)号:US20070191370A1
公开(公告)日:2007-08-16
申请号:US11638677
申请日:2006-12-12
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号: A61K31/53 , A61K31/506 , A61K31/501 , A61K31/4965 , A61K31/497 , A61K31/4439 , C07D403/02
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
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公开(公告)号:US08629156B2
公开(公告)日:2014-01-14
申请号:US13290261
申请日:2011-11-07
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号: C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12 , A61K31/505 , A61P1/00
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
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公开(公告)号:US20100280054A1
公开(公告)日:2010-11-04
申请号:US12750278
申请日:2010-03-30
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号: A61K31/505 , C07D239/47 , A61P1/00
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
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7.4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物及其使用方法公开(公告)号:US08772482B2
公开(公告)日:2014-07-08
申请号:US13162989
申请日:2011-06-17
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: C07D403/12 , A61K31/506 , A61P1/04 , A61P1/06 , A61K31/4152
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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8.Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds 有权
标题翻译: 使用4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物的方法公开(公告)号:US07968559B2
公开(公告)日:2011-06-28
申请号:US12754341
申请日:2010-04-05
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/506 , A61P35/00 , A61P1/00 , C07D403/12
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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9.Methods of using 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds 有权
标题翻译: 使用4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物的方法公开(公告)号:US20100311764A1
公开(公告)日:2010-12-09
申请号:US12754341
申请日:2010-04-05
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/506 , A61P1/00 , A61P35/00
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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10.4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物及其使用方法公开(公告)号:US07709493B2
公开(公告)日:2010-05-04
申请号:US12468974
申请日:2009-05-20
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: C07D403/12 , A61K31/506 , A61P35/00
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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