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![4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE](/abs-image/US/2014/09/11/US20140256784A1/abs.jpg.150x150.jpg)
1.发明申请4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE 有权4H-THIENO [3,2-C]基于琥珀酸的抑制剂及其使用方法公开(公告)号：US20140256784A1
公开(公告)日：2014-09-11
申请号：US14284106
申请日：2014-05-21
申请人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
发明人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , C07D333/52
摘要： Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
摘要翻译： 本发明描述了可用于抑制Notum果胶乙酰酯酶的化合物，以及包含它们的组合物及其用于治疗影响骨骼的疾病和障碍的方法。
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![4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE](/abs-image/US/2012/11/29/US20120302562A1/abs.jpg.150x150.jpg)
2.发明申请4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE 审中-公开4H-THIENO [3,2-C]基于琥珀酸的抑制剂及其使用方法公开(公告)号：US20120302562A1
公开(公告)日：2012-11-29
申请号：US13478529
申请日：2012-05-23
申请人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
发明人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Jason Patrick HEALY , Qiang HAN , Ross MABON , Praveen PABBA , James TARVER, JR. , Kristen M. TERRANOVA , Ashok TUNOORI , Xiaolian XU
IPC分类号： A61K31/381 , C07D333/74 , A61K31/382 , C07D413/12 , A61K31/5377 , A61P19/10 , A61K31/41 , A61K31/4178 , A61K31/422 , A61K31/4535 , A61K31/4025 , A61K31/4436 , C07D495/04 , C07D409/12
CPC分类号： C07D495/04 , C07D333/52
摘要： Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
摘要翻译： 本发明描述了可用于抑制Notum果胶乙酰酯酶的化合物，以及包含它们的组合物及其用于治疗影响骨骼的疾病和障碍的方法。
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3.发明申请O-LINKED PYRIMIDIN-4-AMINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE TO TREAT CANCER 有权O型连接的吡啶基-4-胺基化合物，包含它们的组合物及其用于治疗癌症的方法公开(公告)号：US20080146571A1
公开(公告)日：2008-06-19
申请号：US11954433
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
IPC分类号： A61K31/506 , C07D239/47 , C07D403/12 , A61K31/519 , A61P35/00 , A61K31/5377 , C07D491/044 , C07D413/12
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
摘要翻译： 描述了O-连接的嘧啶-4-胺类化合物，包含它们的药物组合物及其使用方法。 本发明的具体化合物具有式I：
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4.发明授权O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer 有权O-连接的嘧啶-4-胺类化合物，包含它们的组合物及其用于治疗癌症的方法公开(公告)号：US08093246B2
公开(公告)日：2012-01-10
申请号：US11954433
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
IPC分类号： C07D403/14 , A61K31/506
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
摘要翻译： 描述了O-连接的嘧啶-4-胺类化合物，包含它们的药物组合物及其使用方法。 本发明的具体化合物具有式I：
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![4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use](/abs-image/US/2017/04/18/US09624238B2/abs.jpg.150x150.jpg)
5.发明授权公开(公告)号：US09624238B2
公开(公告)日：2017-04-18
申请号：US14284106
申请日：2014-05-21
申请人： Joseph Barbosa , Kenneth Gordon Carson , Michael Walter Gardyan , Jason Patrick Healy , Qiang Han , Ross Mabon , Praveen Pabba , James Tarver, Jr. , Kristen M. Terranova , Ashok Tunoori , Xiaolian Xu
发明人： Joseph Barbosa , Kenneth Gordon Carson , Michael Walter Gardyan , Jason Patrick Healy , Qiang Han , Ross Mabon , Praveen Pabba , James Tarver, Jr. , Kristen M. Terranova , Ashok Tunoori , Xiaolian Xu
IPC分类号： C07D333/52 , C07D495/04
CPC分类号： C07D495/04 , C07D333/52
摘要： Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
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