公开(公告)号：US07611888B2

公开(公告)日：2009-11-03

申请号：US10563477

申请日：2004-07-05

申请人： Kimoon Kim ,  Jin Koo Kang ,  Woo Seong Jeon ,  Miran Noh ,  Dongwoo Kim ,  Kangkyun Baek

发明人： Kimoon Kim ,  Jin Koo Kang ,  Woo Seong Jeon ,  Miran Noh ,  Dongwoo Kim ,  Kangkyun Baek

IPC分类号： C12M1/34 ,  G01N33/552 ,  C07K1/10 ,  C12Q1/68 ,  G01N33/53 ,  C07D245/00

CPC分类号： C07D487/22 ,  C07B2200/11 ,  G01N33/545 ,  G01N2035/00158

摘要： The present disclosure provides a rotaxane compound that can be used to separate molecules within a linkage layer formed on a solid substrate of a biochip by a predetermined distance. The compound is represented by Formula 1, in which a compound of Formula 3 vertically passes through a cavity of cucurbituril or its derivative of Formula 2. It further provides gene chips, protein chips and sensors for biomaterial assays which use the rotaxane molecules to allow biomaterials to be immobilized on a linkage layer such that they are regularly spaced apart from each other by a predetermined distance.

摘要翻译： 本公开提供了一种轮烷化合物，其可用于将形成在生物芯片的固体基质上的连接层内的分子分离预定距离。 该化合物由式1表示，其中式3的化合物垂直通过葫芦巴或其式II的衍生物的空腔。它还提供用于生物材料测定的基因芯片，蛋白质芯片和传感器，其使用轮烷分子以允许生物材料 被固定在连接层上，使得它们彼此规则地间隔开预定距离。

公开(公告)号：US20060154254A1

公开(公告)日：2006-07-13

申请号：US10563477

申请日：2004-07-05

申请人： Kimoon Kim ,  Jin Kang ,  Woo Jeon ,  Miran Noh ,  Dongwoo Kim ,  Kangkyun Baek

发明人： Kimoon Kim ,  Jin Kang ,  Woo Jeon ,  Miran Noh ,  Dongwoo Kim ,  Kangkyun Baek

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07D487/14

CPC分类号： C07D487/22 ,  C07B2200/11 ,  G01N33/545 ,  G01N2035/00158

摘要： The present disclosure provides a rotaxane compound that can be used to separate molecules within a linkage layer formed on a solid substrate of a biochip by a predetermined distance. The compound is represented by Formula 1, in which a compound of Formula 3 vertically passes through a cavity of cucurbituril or its derivative of Formula 2. It further provides gene chips, protein chips and sensors for biomaterial assays which use the rotaxane molecules to allow biomaterials to be immobilized on a linkage layer such that they are regularly spaced apart from each other by a predetermined distance.