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公开(公告)号:US20190194315A1
公开(公告)日:2019-06-27
申请号:US15737042
申请日:2016-06-17
申请人: Tinya ABRAMS , Steven Bruce COHEN , Joseph Anthony D'Alessio , Jason Damiano , Clemens Durr , Bernhard Hubert GEIERSTANGER , Qi-Ying HU , Thomas HUBER , Hidetomo IMASE , Yunho JIN , Daniel MENEZES , Kathy MILLER , Morvarid MOHSENI , Weijia OU , Katherine RENDAHL , Tetsuo UNO , Yongqin WAN , Xing WANG
发明人: Tinya ABRAMS , Steven Bruce COHEN , Joseph Anthony D'Alessio , Jason Damiano , Clemens Durr , Bernhard Hubert GEIERSTANGER , Qi-Ying HU , Thomas HUBER , Hidetomo IMASE , Yunho JIN , Daniel MENEZES , Kathy MILLER , Morvarid MOHSENI , Weijia OU , Katherine RENDAHL , Tetsuo UNO , Yongqin WAN , Xing WANG
CPC分类号: C07K16/28 , A61K38/07 , A61K45/06 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0058 , A61K51/10 , A61K2039/505 , A61P35/00 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.