公开(公告)号：US20190194315A1

公开(公告)日：2019-06-27

申请号：US15737042

申请日：2016-06-17

申请人： Tinya ABRAMS ,  Steven Bruce COHEN ,  Joseph Anthony D'Alessio ,  Jason Damiano ,  Clemens Durr ,  Bernhard Hubert GEIERSTANGER ,  Qi-Ying HU ,  Thomas HUBER ,  Hidetomo IMASE ,  Yunho JIN ,  Daniel MENEZES ,  Kathy MILLER ,  Morvarid MOHSENI ,  Weijia OU ,  Katherine RENDAHL ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

发明人： Tinya ABRAMS ,  Steven Bruce COHEN ,  Joseph Anthony D'Alessio ,  Jason Damiano ,  Clemens Durr ,  Bernhard Hubert GEIERSTANGER ,  Qi-Ying HU ,  Thomas HUBER ,  Hidetomo IMASE ,  Yunho JIN ,  Daniel MENEZES ,  Kathy MILLER ,  Morvarid MOHSENI ,  Weijia OU ,  Katherine RENDAHL ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

IPC分类号： C07K16/28 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  A61K38/07

CPC分类号： C07K16/28 ,  A61K38/07 ,  A61K45/06 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6849 ,  A61K49/0058 ,  A61K51/10 ,  A61K2039/505 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US20160311853A1

公开(公告)日：2016-10-27

申请号：US15104727

申请日：2014-12-17

申请人： Bernhard Hubert GEIERSTANGER ,  Jan GRUNEWALD ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG ,  Yunho JIN

发明人： Bernhard Hubert GEIERSTANGER ,  Jan GRUNEWALD ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG ,  Yunho JIN

IPC分类号： C07K5/02 ,  A61K47/48 ,  C07K7/02 ,  C07K16/32

CPC分类号： C07K5/0205 ,  A61K47/6817 ,  A61K47/6851 ,  C07K7/02 ,  C07K16/32

摘要： Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

摘要翻译： 并且这样的肽在制备免疫偶联物中的用途（即抗体药物偶联物）本文还描述了包含与抗原结合部分如抗体连接的新型细胞毒肽的免疫偶联物（即抗体药物偶联物） 其中这种免疫偶联物可用于治疗细胞增殖性疾病。 本发明还提供包含这些免疫缀合物的药物组合物，包含免疫偶联物与治疗性助剂的组合物，以及使用这些免疫缀合物和组合物治疗细胞增殖障碍的方法。