公开(公告)号：US20190194315A1

公开(公告)日：2019-06-27

申请号：US15737042

申请日：2016-06-17

Applicant: Tinya ABRAMS ,  Steven Bruce COHEN ,  Joseph Anthony D'Alessio ,  Jason Damiano ,  Clemens Durr ,  Bernhard Hubert GEIERSTANGER ,  Qi-Ying HU ,  Thomas HUBER ,  Hidetomo IMASE ,  Yunho JIN ,  Daniel MENEZES ,  Kathy MILLER ,  Morvarid MOHSENI ,  Weijia OU ,  Katherine RENDAHL ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

Inventor： Tinya ABRAMS ,  Steven Bruce COHEN ,  Joseph Anthony D'Alessio ,  Jason Damiano ,  Clemens Durr ,  Bernhard Hubert GEIERSTANGER ,  Qi-Ying HU ,  Thomas HUBER ,  Hidetomo IMASE ,  Yunho JIN ,  Daniel MENEZES ,  Kathy MILLER ,  Morvarid MOHSENI ,  Weijia OU ,  Katherine RENDAHL ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

IPC: C07K16/28 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  A61K38/07

CPC classification number: C07K16/28 ,  A61K38/07 ,  A61K45/06 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6849 ,  A61K49/0058 ,  A61K51/10 ,  A61K2039/505 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US09988420B2

公开(公告)日：2018-06-05

申请号：US15104727

申请日：2014-12-17

Applicant: Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia Ou ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang ,  Yunho Jin

Inventor： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia Ou ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang ,  Yunho Jin

IPC: A61K38/00 ,  C07K5/02 ,  C07K7/02 ,  C07K16/32 ,  A61K47/68

CPC classification number: C07K5/0205 ,  A61K47/6817 ,  A61K47/6851 ,  C07K7/02 ,  C07K16/32

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：US20170121282A1

公开(公告)日：2017-05-04

申请号：US15317532

申请日：2015-06-11

Applicant: Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia OU ,  Shifeng Pan ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang

Inventor： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia OU ,  Shifeng Pan ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang

IPC: C07D207/09 ,  C07K16/32 ,  C07D413/12 ,  C07D403/14 ,  C07D403/12 ,  C07D401/12

CPC classification number: C07D207/09 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07K5/0205 ,  C07K16/32

Abstract: Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：US09181238B2

公开(公告)日：2015-11-10

申请号：US13577209

申请日：2011-02-04

Applicant: Shifeng Pan ,  John E. Tellew ,  Yongqin Wan ,  Yongping Xie ,  Xing Wang ,  Xia Wang ,  Shenlin Huang ,  Zuosheng Liu ,  Qiong Zhang

Inventor： Shifeng Pan ,  John E. Tellew ,  Yongqin Wan ,  Yongping Xie ,  Xing Wang ,  Xia Wang ,  Shenlin Huang ,  Zuosheng Liu ,  Qiong Zhang

IPC: A61K31/444 ,  C07D213/75 ,  C07D471/04 ,  C07D401/14 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  C07D401/14

Abstract: The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract translation: 本发明提供了一类新颖的式（I）化合物（其中A，Y，R 2，R 3，R 4和R 5在本发明概述中定义），包含这些化合物的药物组合物和使用这些化合物治疗或 预防与异常或失调的激酶活性相关的疾病或病症，特别是涉及B-Raf异常活化的疾病或病症。

公开(公告)号：US08101608B2

公开(公告)日：2012-01-24

申请号：US11718886

申请日：2005-11-07

Applicant: Yongqin Wan ,  Yuan Mi ,  Yi Fan ,  Dai Cheng ,  Yi Liu ,  Nathanael S. Gray ,  Pamela Albaugh

Inventor： Yongqin Wan ,  Yuan Mi ,  Yi Fan ,  Dai Cheng ,  Yi Liu ,  Nathanael S. Gray ,  Pamela Albaugh

IPC: A61K31/404 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/496 ,  C07D401/14 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D403/14 ,  C07D403/06

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.

Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，Bcr-Abl异常活化的疾病或病症 ，cSrc，TPR-Met，Tie2，MET，FGFR3，Aurora，Ax1，Bmx，BTK，c-kit，CHK2，Flt3，MST2，p70S6K，PDGFR，PKB，PKC，Raf，ROCK-II，Rsk1，SGK，TrkA ，TrkB和TrkC激酶。

公开(公告)号：US20100183564A1

公开(公告)日：2010-07-22

申请号：US12608946

申请日：2009-10-29

Applicant: Anthony E. Boitano ,  Michael Cooke ,  Shifeng Pan ,  Peter G. Schultz ,  John Tellew ,  Yongqin Wan ,  Xing Wang

Inventor： Anthony E. Boitano ,  Michael Cooke ,  Shifeng Pan ,  Peter G. Schultz ,  John Tellew ,  Yongqin Wan ,  Xing Wang

IPC: A61K35/28 ,  C07D473/34 ,  A61K31/52 ,  A61P35/02 ,  A61P35/00 ,  A61P7/06 ,  A61P37/00 ,  C12N5/0789 ,  C12N5/078

CPC classification number: A61K35/28 ,  A61K9/0019 ,  A61K31/52 ,  A61K38/00 ,  A61K2035/124 ,  C07D473/16 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C12N5/0647 ,  C12N2501/38 ,  C12N2501/60

Abstract: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.

Abstract translation: 本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。 本发明还涉及包含扩大的造血干细胞（HSCs）的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫性疾病和多种造血障碍的患者的细胞群，以重建造血细胞谱系和免疫系统防御。

公开(公告)号：US20090221547A1

公开(公告)日：2009-09-03

申请号：US12063804

申请日：2006-08-22

Applicant: Wenqi Gao ,  Yongqin Wan ,  Jiqing Jiang ,  Yi Fan ,  Nathanael S. Gray ,  Shifeng Pan

Inventor： Wenqi Gao ,  Yongqin Wan ,  Jiqing Jiang ,  Yi Fan ,  Nathanael S. Gray ,  Shifeng Pan

IPC: A61K31/397 ,  C07D213/79 ,  A61K31/44 ,  C07D233/54 ,  A61K31/4164 ,  C07D213/02 ,  C07D401/02 ,  A61K31/4439 ,  C07D417/02 ,  A61K31/4436 ,  C07D239/02 ,  A61K31/505 ,  C07D241/10 ,  A61K31/4965 ,  A61P37/06 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D213/79 ,  C07D209/12 ,  C07D213/54 ,  C07D213/80 ,  C07D213/81 ,  C07D213/84 ,  C07D213/86 ,  C07D213/89 ,  C07D231/12 ,  C07D233/90 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D277/56 ,  C07D401/04 ,  C07D401/06 ,  C07D413/04 ,  C07D417/12

Abstract: The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction. This application relates to compounds selected from Formula (Ia), (Ib), (Ic) and (Id).

Abstract translation: 本发明涉及免疫抑制剂，其制备方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。 本申请涉及选自式（Ia），（Ib），（Ic）和（Id）的化合物。

公开(公告)号：US09580426B2

公开(公告)日：2017-02-28

申请号：US13857939

申请日：2013-04-05

Applicant: Anthony E. Boitano ,  Michael Cooke ,  Shifeng Pan ,  Peter G. Schultz ,  John Tellew ,  Yongqin Wan ,  Xing Wang

Inventor： Anthony E. Boitano ,  Michael Cooke ,  Shifeng Pan ,  Peter G. Schultz ,  John Tellew ,  Yongqin Wan ,  Xing Wang

IPC: C07D473/34 ,  A61K38/00 ,  C07D487/04 ,  C12N5/0789 ,  C07D473/16 ,  C07D495/04

CPC classification number: A61K35/28 ,  A61K9/0019 ,  A61K31/52 ,  A61K38/00 ,  A61K2035/124 ,  C07D473/16 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  C12N5/0647 ,  C12N2501/38 ,  C12N2501/60

Abstract: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.

Abstract translation: 本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。 本发明还涉及包含扩大的造血干细胞（HSCs）的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫性疾病和多种造血障碍的患者的细胞群，以重建造血细胞谱系和免疫系统防御。

公开(公告)号：US20160311853A1

公开(公告)日：2016-10-27

申请号：US15104727

申请日：2014-12-17

Applicant: Bernhard Hubert GEIERSTANGER ,  Jan GRUNEWALD ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG ,  Yunho JIN

Inventor： Bernhard Hubert GEIERSTANGER ,  Jan GRUNEWALD ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG ,  Yunho JIN

IPC: C07K5/02 ,  A61K47/48 ,  C07K7/02 ,  C07K16/32

CPC classification number: C07K5/0205 ,  A61K47/6817 ,  A61K47/6851 ,  C07K7/02 ,  C07K16/32

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

Abstract translation: 并且这样的肽在制备免疫偶联物中的用途（即抗体药物偶联物）本文还描述了包含与抗原结合部分如抗体连接的新型细胞毒肽的免疫偶联物（即抗体药物偶联物） 其中这种免疫偶联物可用于治疗细胞增殖性疾病。 本发明还提供包含这些免疫缀合物的药物组合物，包含免疫偶联物与治疗性助剂的组合物，以及使用这些免疫缀合物和组合物治疗细胞增殖障碍的方法。

公开(公告)号：US08507491B2

公开(公告)日：2013-08-13

申请号：US13060426

申请日：2009-08-24

Applicant: Dai Cheng ,  Dong Han ,  Guobao Zhang ,  Yongqin Wan ,  Yun Feng Xie ,  Jiqing Jiang ,  Wenqi Gao ,  Shifeng Pan

Inventor： Dai Cheng ,  Dong Han ,  Guobao Zhang ,  Yongqin Wan ,  Yun Feng Xie ,  Jiqing Jiang ,  Wenqi Gao ,  Shifeng Pan

IPC: A61K31/501 ,  A61K31/4725 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/472 ,  A61K31/4427 ,  A61P35/00

CPC classification number: C07D401/12 ,  A61K31/47 ,  C07D217/04 ,  C07D217/08 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D513/04

Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).

Abstract translation: 本发明提供了调节刺猬蛋白信号通路活性的方法，化合物和组合物。 特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或GIi功能增益等表型引起的异常生长状态的方法，包括使细胞接触 与足量的式（I）化合物反应。