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公开(公告)号：US06624307B1
公开(公告)日：2003-09-23
申请号：US10109434
申请日：2002-03-28
IPC分类号： C07D21309
CPC分类号： C07D213/69
摘要： Commercially viable process for producing 2,6-dihydroxy-3,4-dimethlpridine. The process includes reacting 2-cyanoacetamide with sodium methoxide followed by condensation with ethyl 2-methylacetoacetate in methanol to give the sodium salt of 2,6-dihydroxy-4,5-dimethyl-3-pyridinecarbonitrile. The sodium salt of 2,6-dihydroxy-4,5-dimethyl-3-pyridinecarbonitrile is hydrolyzed with hydrobromic acid and decarboxylated to the hydrobromide salt of 2,6-dihydroxy-3,4-dimethylpyridine. The desired 2,6-dihydroxy-3,4-dimethylpyridine is produced from the hydrobromide salt by neutralizing the same with sodium hydroxide.
摘要翻译： 用于生产2,6-二羟基-3,4-二甲基吡啶的商业上可行的方法。 该方法包括使2-氰基乙酰胺与甲醇钠反应，然后与2-甲基乙酰乙酸乙酯在甲醇中缩合，得到2,6-二羟基-4,5-二甲基-3-吡啶甲腈的钠盐。 2,6-二羟基-4,5-二甲基-3-吡啶腈的钠盐用氢溴酸水解，脱羧成2,6-二羟基-3,4-二甲基吡啶的氢溴酸盐。 所需的2,6-二羟基-3,4-二甲基吡啶由氢溴酸盐通过用氢氧化钠中和而产生。
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公开(公告)号：US06982346B2
公开(公告)日：2006-01-03
申请号：US10611095
申请日：2003-07-01
CPC分类号： C07C231/12 , A61K8/42 , A61Q19/00 , C07C231/24 , C07C235/08
摘要： A process of making D-panthenyl triacetate which includes reacting D-panthenol with acetic anhydride in the presence of the catalyst polymer bound dimethylaminopyridine to form an exothermic mixture. The so-produced acetic acid, and the catalyst are removed from the exothermic mixture which is then neutralized with sodium hydroxide. Sodium acetate in the form of a solid is removed by filtration. The D-panthenyl triacetate is useful in cosmetic compositions.
摘要翻译： 一种制备D-三苯基三乙酸酯的方法，其包括在催化剂聚合物结合的二甲基氨基吡啶存在下使D-泛醇与乙酸酐反应以形成放热混合物。 如此生产的乙酸和催化剂从放热混合物中除去，然后用氢氧化钠中和。 通过过滤除去固体形式的乙酸钠。 三聚乙酸三苯乙酯可用于化妆品组合物中。
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公开(公告)号：US20050002972A1
公开(公告)日：2005-01-06
申请号：US10611095
申请日：2003-07-01
申请人： Jon Smith , Zongzheng Liu , Murugappa Vedachalam , David Compton
发明人： Jon Smith , Zongzheng Liu , Murugappa Vedachalam , David Compton
IPC分类号： A61K8/42 , A61Q19/00 , C07C231/12 , C07C231/24 , C07C235/08 , C07C67/02 , A61K9/00
CPC分类号： C07C231/12 , A61K8/42 , A61Q19/00 , C07C231/24 , C07C235/08
摘要： A process of making D-panthenyl triacetate which includes reacting D-panthenol with acetic anhydride in the presence of the catalyst polymer bound dimethylaminopyridine to form an exothermic mixture. The so-produced acetic acid, and the catalyst are removed from the exothermic mixture which is then neutralized with sodium hydroxide. Sodium acetate in the form of a solid is removed by filtration. The D-panthenyl triacetate is useful in cosmetic compositions.
摘要翻译： 一种制备D-三苯基三乙酸酯的方法，其包括在催化剂聚合物结合的二甲基氨基吡啶存在下使D-泛醇与乙酸酐反应以形成放热混合物。 如此生产的乙酸和催化剂从放热混合物中除去，然后用氢氧化钠中和。 通过过滤除去固体形式的乙酸钠。 三聚乙酸三苯乙酯可用于化妆品组合物中。
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