公开(公告)号：US6015881A

公开(公告)日：2000-01-18

申请号：US71877

申请日：1998-05-01

申请人： Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader ,  Gene Merutka

发明人： Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader ,  Gene Merutka

IPC分类号： C07K14/16 ,  A61K38/00 ,  C07K5/00

CPC分类号： C07K14/005 ,  C12N2740/16122

摘要： The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

摘要翻译： 本发明首先涉及合成肽，特别是T-20（也称为“DP-178”; SEQ ID NO：1）和T-20样肽的方法。 这些方法利用固相和液相合成方法来合成和组合特定肽片段的组合以产生感兴趣的肽。 本发明还涉及在合成目标肽（例如T-20）中充当中间体的单个肽片段。 本发明还涉及可以一起用于产生全长T-20和T-20样肽的这种肽中间体片段的基团。

公开(公告)号：US20100016225A1

公开(公告)日：2010-01-21

申请号：US12478310

申请日：2009-06-04

申请人： Brian Bray ,  Myung-Chol kang ,  Nicolai Tvermoes ,  Daniel Kinder ,  John William Lackey ,  Huyi Zhang

发明人： Brian Bray ,  Myung-Chol kang ,  Nicolai Tvermoes ,  Daniel Kinder ,  John William Lackey ,  Huyi Zhang

IPC分类号： C07K14/16 ,  C12N7/02 ,  A61K38/10 ,  A61K38/16 ,  C07K7/08 ,  A61P31/18

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K47/60 ,  C12N2740/16122

摘要： Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit transmission of HIV to a target cell by adding an amount of effective to inhibit infection of the cell by the virus; and methods of producing the conjugates by operably binding each molecule of synthetic peptide, via a reactive functionality, to the polymer.

摘要翻译： 提供了包含具有可操作地结合有不少于两个来自HIV gp41的合成肽的两分子的聚合物的缀合物; 使用这些缀合物通过添加有效抑制病毒感染的量来抑制HIV向目标细胞传播的方法; 以及通过将每个分子的合成肽通过反应性官能团可操作地结合到聚合物来生产缀合物的方法。

公开(公告)号：US07556813B2

公开(公告)日：2009-07-07

申请号：US10671282

申请日：2003-09-24

申请人： Brian Bray ,  Myung-Chol Kang ,  Nicolai Tvermoes ,  Daniel Kinder ,  John William Lackey ,  Huyi Zhang

发明人： Brian Bray ,  Myung-Chol Kang ,  Nicolai Tvermoes ,  Daniel Kinder ,  John William Lackey ,  Huyi Zhang

IPC分类号： A61K39/3085 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K47/60 ,  C12N2740/16122

摘要： Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit transmission of HIV to a target cell by adding an amount of effective to inhibit infection of the cell by the virus; and methods of producing the conjugates by operably binding each molecule of synthetic peptide, via a reactive functionality, to the polymer.

摘要翻译： 提供了包含具有可操作地结合有不少于两个来自HIV gp41的合成肽的两分子的聚合物的缀合物; 使用这些缀合物通过添加有效抑制病毒感染的量来抑制HIV向目标细胞传播的方法; 以及通过将每个分子的合成肽通过反应性官能团可操作地结合到聚合物来生产缀合物的方法。

公开(公告)号：US06767993B2

公开(公告)日：2004-07-27

申请号：US10109748

申请日：2002-03-29

申请人： Brian Bray ,  Marc Andersen ,  Paul Erickson Friedrich ,  Myung-Chol Kang

发明人： Brian Bray ,  Marc Andersen ,  Paul Erickson Friedrich ,  Myung-Chol Kang

IPC分类号： C12P2106

CPC分类号： C07K14/005 ,  C12N2740/16122

摘要： The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T-1249-like peptides.

摘要翻译： 本发明首先涉及用于合成被称为T-1249和T-1249样肽的肽的方法。 这些方法利用固相和液相合成方法来合成和组合特定肽片段的基团以产生感兴趣的肽。 本发明还涉及在合成感兴趣的肽（例如T-1249）中充当中间体的单个肽片段。 本发明还涉及可以一起用于产生全长T-1249和T-1249样肽的这种肽中间体片段的基团。

公开(公告)号：US06469136B1

公开(公告)日：2002-10-22

申请号：US09349205

申请日：1999-07-07

申请人： Brian Bray ,  Marc Andersen ,  Paul Erickson Friedrich ,  Myung-Chol Kang

发明人： Brian Bray ,  Marc Andersen ,  Paul Erickson Friedrich ,  Myung-Chol Kang

IPC分类号： A61K3800

CPC分类号： C07K14/005 ,  C12N2740/16122

摘要： The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T-1249-like peptides.

摘要翻译： 本发明首先涉及用于合成被称为T-1249和T-1249样肽的肽的方法。 这些方法利用固相和液相合成方法来合成和组合特定肽片段的组合以产生感兴趣的肽。 本发明还涉及在合成感兴趣的肽（例如T-1249）中充当中间体的单个肽片段。 本发明还涉及可以一起用于产生全长T-1249和T-1249样肽的这种肽中间体片段的基团。

公开(公告)号：US06281331B1

公开(公告)日：2001-08-28

申请号：US09045920

申请日：1998-03-23

申请人： Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader

发明人： Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader

IPC分类号： C07K706

CPC分类号： C07K14/005 ,  C12N2740/16122

摘要： The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as “DP-178”; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

摘要翻译： 本发明首先涉及合成肽，特别是T-20（也称为“DP-178”; SEQ ID NO：1）和T-20样肽的方法。 这些方法利用固相和液相合成方法来合成和组合特定肽片段的基团以产生感兴趣的肽。 本发明还涉及在合成目标肽（例如T-20）中充当中间体的单个肽片段。 本发明还涉及可以一起用于产生全长T-20和T-20样肽的这种肽中间体片段的基团。