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1.发明授权Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides 失效包含共价连接到两个或更多个合成的HIV gp41 HR1和/或HR2肽的聚合物的抗病毒肽 - 聚合物缀合物公开(公告)号：US07556813B2
公开(公告)日：2009-07-07
申请号：US10671282
申请日：2003-09-24
申请人： Brian Bray , Myung-Chol Kang , Nicolai Tvermoes , Daniel Kinder , John William Lackey , Huyi Zhang
发明人： Brian Bray , Myung-Chol Kang , Nicolai Tvermoes , Daniel Kinder , John William Lackey , Huyi Zhang
IPC分类号： A61K39/3085 , A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , A61K47/60 , C12N2740/16122
摘要： Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit transmission of HIV to a target cell by adding an amount of effective to inhibit infection of the cell by the virus; and methods of producing the conjugates by operably binding each molecule of synthetic peptide, via a reactive functionality, to the polymer.
摘要翻译： 提供了包含具有可操作地结合有不少于两个来自HIV gp41的合成肽的两分子的聚合物的缀合物; 使用这些缀合物通过添加有效抑制病毒感染的量来抑制HIV向目标细胞传播的方法; 以及通过将每个分子的合成肽通过反应性官能团可操作地结合到聚合物来生产缀合物的方法。
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公开(公告)号：US07030150B2
公开(公告)日：2006-04-18
申请号：US10141839
申请日：2002-05-09
IPC分类号： A61K31/4184 , C07D403/14
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D235/12 , C07D235/14 , C07D249/08 , C07D401/06 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07F9/65068 , C07F9/65583
摘要： The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or otherwise treat viral infections. The invention also encompasses the use of benzimidazole compounds as inhibitors of membrane fusion associated events, such as viral transmission. In another embodiment, the invention encompasses processes for making benzimidazole compounds, methods of using the benzimidazole compounds and compositions comprising the benzimidazole compounds. Finally, the invention provides methods for treating, preventing or ameliorating symptoms associated with respiratory infection, particularly that caused by Respiratory Syncytial Virus utilizing the novel benzimidazole compounds of the invention.
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3.发明授权Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission 失效用于抑制膜融合相关事件（包括HIV传播）的方法和组合物公开(公告)号：US06750008B1
公开(公告)日：2004-06-15
申请号：US09350841
申请日：1999-07-09
申请人： Peter Jeffs , John William Lackey , Joel Burton Erickson , Mary Katherine Lawless , Gene Merutka
发明人： Peter Jeffs , John William Lackey , Joel Burton Erickson , Mary Katherine Lawless , Gene Merutka
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/162 , C12N2710/16322 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18722 , G01N33/68 , G01N2500/00
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译： 本发明涉及显示出有力的抗逆转录病毒活性的肽。 本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽，以及DP178的片段，类似物和同系物。 本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。
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4.发明申请CONJUGATES COMPRISED OF POLYMER AND HIV gp-41-DERIVED PEPTIDES AND THEIR USE IN THERAPY 审中-公开聚合物和HIV gp-41衍生肽及其在治疗中的应用公开(公告)号：US20100016225A1
公开(公告)日：2010-01-21
申请号：US12478310
申请日：2009-06-04
申请人： Brian Bray , Myung-Chol kang , Nicolai Tvermoes , Daniel Kinder , John William Lackey , Huyi Zhang
发明人： Brian Bray , Myung-Chol kang , Nicolai Tvermoes , Daniel Kinder , John William Lackey , Huyi Zhang
CPC分类号： C07K14/005 , A61K38/00 , A61K47/60 , C12N2740/16122
摘要： Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit transmission of HIV to a target cell by adding an amount of effective to inhibit infection of the cell by the virus; and methods of producing the conjugates by operably binding each molecule of synthetic peptide, via a reactive functionality, to the polymer.
摘要翻译： 提供了包含具有可操作地结合有不少于两个来自HIV gp41的合成肽的两分子的聚合物的缀合物; 使用这些缀合物通过添加有效抑制病毒感染的量来抑制HIV向目标细胞传播的方法; 以及通过将每个分子的合成肽通过反应性官能团可操作地结合到聚合物来生产缀合物的方法。
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