公开(公告)号：US20150080567A1

公开(公告)日：2015-03-19

申请号：US14471593

申请日：2014-08-28

Applicant: Nalas Engineering Services Inc.

Inventor： Jerry Salan ,  Stephen R. Anderson ,  David J. am Ende

IPC: C30B30/06 ,  C07D213/82 ,  C07D487/18 ,  C07D257/02 ,  C30B1/12 ,  C07C47/54 ,  C07C229/60 ,  B01F11/00 ,  B01F3/18 ,  C30B7/14 ,  C07D225/08 ,  C07D213/38

CPC classification number: C30B30/06 ,  B01F3/18 ,  B01F11/008 ,  B01F2215/0032 ,  C06B21/0066 ,  C06B25/34 ,  C07B2200/13 ,  C07C47/54 ,  C07C229/60 ,  C07D213/38 ,  C07D213/82 ,  C07D223/26 ,  C07D225/08 ,  C07D257/02 ,  C07D487/18 ,  C07D487/22 ,  C30B1/12 ,  C30B7/14

Abstract: A method to produce and manufacture cocrystals and salts is disclosed wherein crystalline solids and other components were combined in the desired proportions into a mixing chamber and mixed at high intensity to afford a cocrystalline product. No grinding media were required. The mixing system consists of a resonant acoustic vibratory system capable of supplying a large amount of energy to the mixture and is tunable to a desired resonance frequency and amplitude. The use of resonant acoustic mixing to assist cocrystallization is novel. This discovery enables the manufacture of cocrystals and salt forms, simplifying their manufacture and scale-up, and avoiding the use of grinding methods or grinding media. The present invention affords the manufacture of cocrystals and salts on kilogram to multi-ton scale and is adaptable to continuous manufacturing through the use of resonant mixing methods.

Abstract translation: 公开了一种生产和制造共晶体和盐的方法，其中将结晶固体和其它组分以所需比例合并到混合室中并以高强度混合以提供共晶产物。 不需要研磨介质。 混合系统由能够向混合物提供大量能量并且可调谐到期望的共振频率和振幅的共振声振动系统组成。 使用共振声学混合来辅助共结晶是新颖的。 这一发现使得能够制造共晶和盐形式，简化其制造和放大，并避免使用研磨方法或研磨介质。 本发明提供以千吨至多吨规模生产共晶和盐，并且通过使用共振混合方法适应于连续制造。

公开(公告)号：US20150361056A1

公开(公告)日：2015-12-17

申请号：US14674146

申请日：2015-03-31

Applicant: Nalas Engineering Services Inc.

Inventor： Jerry SALAN ,  David J. am ENDE ,  Stephen R. ANDERSON

IPC: C07D249/14 ,  C30B29/54 ,  C07D487/22 ,  C30B7/14

CPC classification number: C07D249/14 ,  C07D487/22 ,  C30B7/06 ,  C30B29/54 ,  C30B30/06

Abstract: A cocrystal of CL-20 (2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane) and DNMT (1-methyl-3,5-dinitro-1,2,4-triazole) was formed through a resonant acoustic mixing process. The resulting cocrystal comprised an essentially 1:1 stoichiometric ratio between these coformers. The cocrystal advantageously has decreased sensitivity when compared with a pure CL-20 sample, and maintains thermal stability and comparable energetic performance.

Abstract translation: CL-20（2,4,6,8,10,12-六硝基-2,4,6,8,10,12-六氮杂异纤锌矿型结构烷烃）和DNMT（1-甲基-3,5-二硝基-1， 2,4-三唑）通过共振声音混合过程形成。 所得共晶体在这些共形成器之间包含基本上1:1的化学计量比。 与纯CL-20样品相比，共晶体有利地具有降低的灵敏度，并且保持热稳定性和可比的能量性能。